Sites on a Tree

 

Searching for up to 100 curated homologs for WP_104488606.1 NCBI__GCF_002936955.1:WP_104488606.1 (554 a.a.)

Found high-coverage hits (≥70%) to 41 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

AsnB / b0674 asparagine synthetase B (EC 6.3.5.4; EC 6.3.1.1; EC 3.5.1.38; EC 3.5.1.2) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
asnB / P22106 asparagine synthetase B (EC 6.3.5.4; EC 6.3.1.1; EC 3.5.1.38) from Escherichia coli (strain K12) (see 17 papers)
ASNB_ECOLI / P22106 Asparagine synthetase B [glutamine-hydrolyzing]; AS-B; EC 6.3.5.4 from Escherichia coli (strain K12) (see 6 papers)
asnB asparagine synthetase B, glutamine-hydrolyzing; EC 6.3.5.4 from Escherichia coli (see paper)
    73% identity, 100% coverage of query (872 bits)

1ct9A / P22106 Crystal structure of asparagine synthetase b from escherichia coli (see paper)
    71% identity, 93% coverage of query (768 bits)

B3KYI2 asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) from Phaseolus vulgaris (see paper)
    57% identity, 100% coverage of query (641 bits)

ASNS2_ORYSJ / Q43011 Asparagine synthetase [glutamine-hydrolyzing] 2; Glutamine-dependent asparagine synthetase 2; EC 6.3.5.4 from Oryza sativa subsp. japonica (Rice) (see paper)
Q43011 asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) from Oryza sativa Japonica Group (see paper)
    56% identity, 100% coverage of query (639 bits)

F2CQ60 asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) from Hordeum vulgare subsp. vulgare (see paper)
    56% identity, 100% coverage of query (639 bits)

F2DJ31 asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) from Hordeum vulgare (see paper)
    56% identity, 100% coverage of query (638 bits)

ASNS2_ARATH / Q9LV77 Asparagine synthetase [glutamine-hydrolyzing] 2; Glutamine-dependent asparagine synthetase 2; EC 6.3.5.4 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    57% identity, 99% coverage of query (637 bits)

Q14SM9 asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) from Glycine max (see paper)
    56% identity, 100% coverage of query (636 bits)

Q10MX3 asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) from Oryza sativa Japonica Group (see paper)
    56% identity, 99% coverage of query (634 bits)

Q9SP19 asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) from Helianthus annuus (see paper)
    56% identity, 100% coverage of query (633 bits)

Q6HA26 asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) from Pinus sylvestris (see paper)
    55% identity, 100% coverage of query (628 bits)

E7EAQ2 asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) from Pinus pinaster (see paper)
    55% identity, 100% coverage of query (628 bits)

Q9SM55 asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) from Phaseolus vulgaris (see paper)
    55% identity, 100% coverage of query (626 bits)

A0A1D5VHV8 asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) from Triticum aestivum (see paper)
    55% identity, 100% coverage of query (624 bits)

D9IXC8 asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) from Pinus pinaster (see paper)
    55% identity, 100% coverage of query (622 bits)

ASNS1_ARATH / P49078 Asparagine synthetase [glutamine-hydrolyzing] 1; Glutamine-dependent asparagine synthetase 1; Protein DARK INDUCIBLE 6; EC 6.3.5.4 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    54% identity, 100% coverage of query (622 bits)

Q93XP9 asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) from Hordeum vulgare subsp. vulgare (see paper)
    54% identity, 100% coverage of query (619 bits)

A0A1D5YL35 asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) from Triticum aestivum (see paper)
    54% identity, 100% coverage of query (619 bits)

F2CWZ7 asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) from Hordeum vulgare subsp. vulgare (see paper)
    55% identity, 100% coverage of query (618 bits)

A9XS73 asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) from Phaseolus vulgaris (see paper)
    55% identity, 100% coverage of query (617 bits)

Q9SP20 asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) from Helianthus annuus (see paper)
    55% identity, 100% coverage of query (615 bits)

Q84LA5 asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) from Hordeum vulgare (see paper)
    55% identity, 100% coverage of query (614 bits)

Q9LKQ9 asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) from Helianthus annuus (see paper)
    54% identity, 100% coverage of query (607 bits)

ASNS_SCHPO / P78753 Probable asparagine synthetase [glutamine-hydrolyzing]; Glutamine-dependent asparagine synthetase; EC 6.3.5.4 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
asn1 / RF|NP_595291.1 asparagine synthetase; EC 6.3.5.4 from Schizosaccharomyces pombe (see 2 papers)
    52% identity, 99% coverage of query (569 bits)

ASNS2_YEAST / P49090 Asparagine synthetase [glutamine-hydrolyzing] 2; Glutamine-dependent asparagine synthetase 2; EC 6.3.5.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    50% identity, 99% coverage of query (543 bits)

ASN1 asparagine synthetase from Candida albicans (see paper)
    50% identity, 98% coverage of query (541 bits)

F2DDF6 asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) from Hordeum vulgare subsp. vulgare (see paper)
    53% identity, 79% coverage of query (477 bits)

ASNS_MOUSE / Q61024 Asparagine synthetase [glutamine-hydrolyzing]; Glutamine-dependent asparagine synthetase; EC 6.3.5.4 from Mus musculus (Mouse) (see paper)
    40% identity, 99% coverage of query (362 bits)

Asns / P49088 asparagine synthetase subunit (EC 6.3.5.4) from Rattus norvegicus (see paper)
    40% identity, 99% coverage of query (356 bits)

ASNS_HUMAN / P08243 Asparagine synthetase [glutamine-hydrolyzing]; Cell cycle control protein TS11; Glutamine-dependent asparagine synthetase; EC 6.3.5.4 from Homo sapiens (Human) (see 2 papers)
P08243 asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) from Homo sapiens (see 4 papers)
    41% identity, 99% coverage of query (355 bits)

6gq3A / P08243 Human asparagine synthetase (asns) in complex with 6-diazo-5-oxo-l- norleucine (don) at 1.85 a resolution (see paper)
    42% identity, 91% coverage of query (337 bits)

Q2L9S5 asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4) from Bombyx mori (see paper)
    37% identity, 99% coverage of query (305 bits)

Build an alignment

Build an alignment for WP_104488606.1 and 32 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

asnO / GI|1934835 asparagine synthase (glutamine-hydrolysing) 3; EC 6.3.5.4 from Bacillus subtilis (see 3 papers)
    26% identity, 88% coverage of query (179 bits)

asnO / Q92W82 N-acetylglutaminylglutamine amide synthase from Rhizobium meliloti (strain 1021) (see paper)
    28% identity, 82% coverage of query (171 bits)

asnH / Q9CDJ2 peptidoglycan asparagine synthase from Lactococcus lactis subsp. lactis (strain IL1403) (see paper)
    27% identity, 70% coverage of query (143 bits)

1mb9A Beta-lactam synthetase complexed with atp
    27% identity, 74% coverage of query (94.0 bits)

1mc1A Beta-lactam synthetase with product (dgpc), amp and ppi
    26% identity, 75% coverage of query (90.9 bits)

1mbzA Beta-lactam synthetase with trapped intermediate
    26% identity, 75% coverage of query (90.9 bits)

bls / P0DJQ7 β-lactam synthetase (EC 6.3.3.4) from Streptomyces clavuligerus (see 2 papers)
    26% identity, 75% coverage of query (89.4 bits)

1jgtB / P0DJQ7 Crystal structure of beta-lactam synthetase (see paper)
    26% identity, 73% coverage of query (87.0 bits)

ASND1_YEAST / Q04489 Asparagine synthetase domain-containing protein YML096W from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
    25% identity, 74% coverage of query (73.2 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory