Sites on a Tree

 

Searching for up to 100 curated homologs for WP_106709268.1 NCBI__GCF_003010955.1:WP_106709268.1 (403 a.a.)

Found high-coverage hits (≥70%) to 14 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

SMc00833 D-lactate dehydrogenase, FAD binding subunit GlcE (EC 1.1.99.6) from Sinorhizobium meliloti 1021
    51% identity, 100% coverage of query (386 bits)

PGA1_c29710 D-lactate dehydrogenase, FAD binding subunit GlcE (EC 1.1.99.6) from Phaeobacter inhibens BS107
    43% identity, 98% coverage of query (262 bits)

Psest_3840 D-lactate/glycolate dehydrogenase, FAD binding subunit GlcE (EC 1.1.99.6; EC 1.1.99.14) from Pseudomonas stutzeri RCH2
    35% identity, 100% coverage of query (183 bits)

Gox / b4468 glycolate dehydrogenase, putative FAD-binding subunit (EC 1.1.99.14) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
glcE / P52073 glycolate dehydrogenase, putative FAD-binding subunit (EC 1.1.99.14) from Escherichia coli (strain K12) (see 3 papers)
GLCE_ECOLI / P52073 Glycolate oxidase subunit GlcE; Glycolate dehydrogenase subunit GlcE; EC 1.1.99.14 from Escherichia coli (strain K12) (see 4 papers)
glcE / RF|YP_026191.1 glycolate oxidase, subunit glcE from Escherichia coli K12 (see paper)
glcE / AAB02531.1 glycolate oxidase subunit from Escherichia coli (see paper)
    34% identity, 97% coverage of query (179 bits)

RR42_RS17310 D-lactate dehydrogenase, FAD binding subunit GlcE (EC 1.1.99.6) from Cupriavidus basilensis FW507-4G11
    35% identity, 98% coverage of query (159 bits)

Build an alignment

Build an alignment for WP_106709268.1 and 5 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

Q9I6H4 D-2-hydroxyglutarate dehydrogenase (EC 1.1.99.39) from Pseudomonas aeruginosa (see paper)
    25% identity, 83% coverage of query (77.0 bits)

D2HDH_ARATH / O23240 D-2-hydroxyglutarate dehydrogenase, mitochondrial; AtD-2HGDH; EC 1.1.99.39 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    26% identity, 84% coverage of query (70.5 bits)

D2HDH_STUS1 / A4VGK4 D-2-hydroxyglutarate dehydrogenase; D-2-HG dehydrogenase; D2HGDH; D-malate dehydrogenase; EC 1.1.99.39; EC 1.1.99.- from Stutzerimonas stutzeri (strain A1501) (Pseudomonas stutzeri) (see 2 papers)
    24% identity, 83% coverage of query (67.8 bits)

D2HDH_RAT / P84850 D-2-hydroxyglutarate dehydrogenase, mitochondrial; EC 1.1.99.39 from Rattus norvegicus (Rat) (see paper)
    24% identity, 83% coverage of query (62.8 bits)

6lpnB / Q8N465 Crystal structure of human d-2-hydroxyglutarate dehydrogenase in apo form (see paper)
    26% identity, 83% coverage of query (60.5 bits)

6lpxA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with 2-oxoglutarate (2-og)
    26% identity, 83% coverage of query (60.5 bits)

6lpuA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with l-2-hydroxyglutarate (l-2-hg)
    26% identity, 83% coverage of query (60.5 bits)

6lpqA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with d-malate (d-mal)
    26% identity, 83% coverage of query (60.5 bits)

6lppA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with d-2-hydroxyglutarate (d-2-hg)
    26% identity, 83% coverage of query (60.5 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory