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Searching for up to 100 curated homologs for WP_109967067.1 NCBI__GCF_003173355.1:WP_109967067.1 (211 a.a.)

Found high-coverage hits (≥70%) to 20 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

MTQC_EUBLI / P0DX07 Quaternary-amine-specific corrinoid protein; Corrinoid protein MtqC from Eubacterium limosum (see 2 papers)
    40% identity, 97% coverage of query (149 bits)

4jgiB / Q8RPG0 1.5 angstrom crystal structure of a novel cobalamin-binding protein from desulfitobacterium hafniense dcb-2 (see paper)
    38% identity, 95% coverage of query (140 bits)

PGA1_c13350 Methionine synthase component, B12 binding and B12-binding cap domains (EC:2.1.1.13) from Phaeobacter inhibens DSM 17395
    40% identity, 77% coverage of query (134 bits)

mtbC / O93657 dimethylamine corrinoid protein from Methanosarcina barkeri (see paper)
MTBC_METBA / O93657 Dimethylamine corrinoid protein from Methanosarcina barkeri (see 2 papers)
mtbC / GB|AAD14629.1 dimethylamine corrinoid protein from Methanosarcina barkeri (see 2 papers)
    35% identity, 97% coverage of query (124 bits)

mtgC / Q24SP8 glycine betaine-specific corrinoid protein from Desulfitobacterium hafniense (strain Y51) (see paper)
    34% identity, 93% coverage of query (117 bits)

7xcnP / O93659 Crystal structure of the mttb-mttc complex at 2.7 a resolution (see paper)
    33% identity, 93% coverage of query (116 bits)

mttC / O93659 trimethylamine-specific corrinoid protein from Methanosarcina barkeri (see paper)
MTTC_METBA / O93659 Trimethylamine corrinoid protein; TCP from Methanosarcina barkeri (see paper)
    33% identity, 93% coverage of query (116 bits)

Q8THX4 tetrahydromethanopterin S-methyltransferase (EC 2.1.1.86) from Methanosarcina acetivorans (see paper)
    31% identity, 96% coverage of query (111 bits)

DvMF_0476 vitamin B12-dependent methionine synthase without a reactivation domain (EC 2.1.1.13) from Desulfovibrio vulgaris Miyazaki F
    32% identity, 94% coverage of query (105 bits)

DVU1585 Methionine synthase (cobalamin-dependent) (EC 2.1.1.13) from Desulfovibrio vulgaris Hildenborough JW710
    33% identity, 98% coverage of query (103 bits)

Build an alignment

Build an alignment for WP_109967067.1 and 10 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

Q9WYA5 methionine synthase (EC 2.1.1.13) from Thermotoga maritima (see paper)
    29% identity, 85% coverage of query (97.4 bits)

8g3hA / A0A0A2XCD7 Structure of cobalamin-dependent methionine synthase (meth) in a resting state (see paper)
    35% identity, 77% coverage of query (94.7 bits)

metH / Q8NQD1 cobalamin-dependent methionine synthase (EC 2.1.1.13) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
    31% identity, 97% coverage of query (93.2 bits)

8sseA / Q5SKM5 Methionine synthase, c-terminal fragment, cobalamin and reactivation domains from thermus thermophilus hb8 (see paper)
    31% identity, 89% coverage of query (92.4 bits)

mtaC / Q46EH4 Co(I) methanol-specific corrinoid protein from Methanosarcina barkeri (strain Fusaro / DSM 804) (see 6 papers)
MTAC_METBF / Q46EH4 Methanol--corrinoid protein; Methanol:corrinoid methyltransferase 1 subunit of 27 kDa; MT1 subunit 27 kDa from Methanosarcina barkeri (strain Fusaro / DSM 804) (see 2 papers)
Q46EH4 methanol-corrinoid protein Co-methyltransferase (subunit 1/3) (EC 2.1.1.90) from Methanosarcina barkeri (see paper)
2i2xB / Q46EH4 Crystal structure of methanol:cobalamin methyltransferase complex mtabc from methanosarcina barkeri (see paper)
    28% identity, 90% coverage of query (85.1 bits)

3ezxA / O30641 Structure of methanosarcina barkeri monomethylamine corrinoid protein
    31% identity, 80% coverage of query (82.4 bits)

mtmC / O30641 monomethylamine corrinoid protein from Methanosarcina barkeri (see 2 papers)
MTMC1_METBA / O30641 Monomethylamine corrinoid protein 1; MMCP 1 from Methanosarcina barkeri (see paper)
    31% identity, 80% coverage of query (81.3 bits)

MTR / Q99707 cobalamin-dependent methionine synthase (EC 2.1.1.13) from Homo sapiens (see 5 papers)
METH_HUMAN / Q99707 Methionine synthase; MS; 5-methyltetrahydrofolate--homocysteine methyltransferase; Cobalamin-dependent methionine synthase; Vitamin-B12 dependent methionine synthase; EC 2.1.1.13 from Homo sapiens (Human) (see 7 papers)
Q99707 methionine synthase (EC 2.1.1.13) from Homo sapiens (see paper)
    30% identity, 73% coverage of query (81.3 bits)

mtsB / Q48925 methanethiol corrinoid protein from Methanosarcina barkeri (see 3 papers)
MTSB_METBA / Q48925 Methylated-thiol--corrinoid protein MtsB; Methylthiol:coenzyme M methyltransferase 30 kDa subunit from Methanosarcina barkeri (see paper)
    27% identity, 82% coverage of query (69.3 bits)

8j2xA / A0A5Q0H231 Saccharothrix syringae photocobilins protein, light state (see paper)
    26% identity, 82% coverage of query (54.3 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory