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Searching for up to 100 curated homologs for WP_110206665.1 NCBI__GCF_003194585.1:WP_110206665.1 (500 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

P21398 monoamine oxidase (EC 1.4.3.4) from Bos taurus (see 5 papers)
    36% identity, 89% coverage of query (273 bits)

9h5qB / A0AAJ6N6J2 Crystal structure of thermoanaerobacterales bacterium monoamine oxidase in complex with spermidine and its oxidation products (see paper)
    38% identity, 90% coverage of query (272 bits)

9h64A Monoamine oxidase
    38% identity, 90% coverage of query (272 bits)

9h5zB Crystal structure of thermoanaerobacterales bacterium monoamine oxidase in complex with benzylamine
    38% identity, 90% coverage of query (272 bits)

9h5qA Crystal structure of thermoanaerobacterales bacterium monoamine oxidase in complex with spermidine and its oxidation products
    38% identity, 90% coverage of query (272 bits)

9h5pA Crystal structure of thermoanaerobacterales bacterium monoamine oxidase in complex with putrescine
    38% identity, 90% coverage of query (272 bits)

AOF_DANRE / Q6NSN2 Amine oxidase [flavin-containing]; Monoamine oxidase; MAO; Z-MAO; EC 1.4.3.21; EC 1.4.3.4 from Danio rerio (Zebrafish) (Brachydanio rerio) (see 2 papers)
Q6NSN2 monoamine oxidase (EC 1.4.3.4) from Danio rerio (see 2 papers)
    34% identity, 89% coverage of query (268 bits)

1o5wC / P21396 The structure basis of specific recognitions for substrates and inhibitors of rat monoamine oxidase a (see paper)
    34% identity, 89% coverage of query (266 bits)

Q6Q2J0 monoamine oxidase (EC 1.4.3.4) from Sus scrofa (see paper)
    35% identity, 90% coverage of query (265 bits)

AOFA_MOUSE / Q64133 Amine oxidase [flavin-containing] A; Monoamine oxidase type A; MAO-A; EC 1.4.3.21; EC 1.4.3.4 from Mus musculus (Mouse) (see paper)
Q64133 monoamine oxidase (EC 1.4.3.4) from Mus musculus (see 5 papers)
    34% identity, 89% coverage of query (264 bits)

LAADH_SYNY3 / Q55629 L-amino acid dehydrogenase; L-amino acid:plastoquinone oxidoreductase; L-arginine dehydrogenase; EC 1.4.5.- from Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa) (see paper)
Q55629 L-amino-acid dehydrogenase (EC 1.4.1.5) from Synechocystis sp. (see paper)
    35% identity, 91% coverage of query (261 bits)

AOFB_MOUSE / Q8BW75 Amine oxidase [flavin-containing] B; Monoamine oxidase type B; MAO-B; EC 1.4.3.21; EC 1.4.3.4 from Mus musculus (Mouse) (see paper)
Q8BW75 monoamine oxidase (EC 1.4.3.4) from Mus musculus (see 4 papers)
    33% identity, 90% coverage of query (259 bits)

2z5xA / P21397 Crystal structure of human monoamine oxidase a with harmine (see paper)
    34% identity, 89% coverage of query (258 bits)

MAOA / P21397 amine oxidase A (EC 1.4.3.4) from Homo sapiens (see 4 papers)
AOFA_HUMAN / P21397 Amine oxidase [flavin-containing] A; Monoamine oxidase type A; MAO-A; EC 1.4.3.21; EC 1.4.3.4 from Homo sapiens (Human) (see 7 papers)
P21397 monoamine oxidase (EC 1.4.3.4) from Homo sapiens (see 58 papers)
    34% identity, 89% coverage of query (258 bits)

AOFB_RAT / P19643 Amine oxidase [flavin-containing] B; Monoamine oxidase type B; MAO-B; EC 1.4.3.21; EC 1.4.3.4 from Rattus norvegicus (Rat) (see 2 papers)
P19643 monoamine oxidase (EC 1.4.3.4) from Rattus norvegicus (see 26 papers)
    33% identity, 90% coverage of query (256 bits)

3zyxA Crystal structure of human monoamine oxidase b in complex with methylene blue and bearing the double mutation i199a-y326a
    34% identity, 90% coverage of query (251 bits)

AOFB_BOVIN / P56560 Amine oxidase [flavin-containing] B; Monoamine oxidase type B; MAO-B; EC 1.4.3.21; EC 1.4.3.4 from Bos taurus (Bovine) (see 3 papers)
P56560 monoamine oxidase (EC 1.4.3.4) from Bos taurus (see 9 papers)
    35% identity, 90% coverage of query (250 bits)

MAOB / P27338 monoamine oxidase B subunit (EC 1.4.3.21; EC 1.4.3.4) from Homo sapiens (see paper)
AOFB_HUMAN / P27338 Amine oxidase [flavin-containing] B; Monoamine oxidase type B; MAO-B; EC 1.4.3.21; EC 1.4.3.4 from Homo sapiens (Human) (see 10 papers)
P27338 monoamine oxidase (EC 1.4.3.4) from Homo sapiens (see 55 papers)
    34% identity, 90% coverage of query (249 bits)

7b0zA Crystal structure of human monoamine oxidase b in complex with (e)-3- phenyl-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-one
    34% identity, 90% coverage of query (249 bits)

7b0vA Crystal structure of human monoamine oxidase b in complex with (e)-3- phenyl-1-(3-(trifluoromethyl)phenyl)prop-2-en-1-one
    34% identity, 90% coverage of query (249 bits)

7p4hA Crystal structure of monoamine oxidase b in complex with inhibitor (+)-2
    34% identity, 90% coverage of query (249 bits)

7p4fA Crystal structure of monoamine oxidase b in complex with inhibitor 1
    34% identity, 90% coverage of query (249 bits)

6rleA Crystal structure of human monoamine oxidase b in complex with styrylpiperidine analogue 97
    34% identity, 90% coverage of query (249 bits)

6rkpA Crystal structure of human monoamine oxidase b in complex with styrylpiperidine analogue 84
    34% identity, 90% coverage of query (249 bits)

6rkbA Crystal structure of human monoamine oxidase b in complex with styrylpiperidine analogue 1
    34% identity, 90% coverage of query (249 bits)

6fwcA Crystal structure of human monoamine oxidase b (mao b) in complex with fluorophenyl-chromone-carboxamide
    34% identity, 90% coverage of query (249 bits)

5mrlA Crystal structure of human monoamine oxidase b (mao b) in complex with n(furan2ylmethyl)nmethylprop2yn1amine (f2mpa)
    34% identity, 90% coverage of query (249 bits)

4crtA Crystal structure of human monoamine oxidase b in complex with the multi-target inhibitor ass234
    34% identity, 90% coverage of query (249 bits)

4a7aA Crystal structure of human monoamine oxidase b (mao b) in complex with rosiglitazone
    34% identity, 90% coverage of query (249 bits)

4a79A Crystal structure of human monoamine oxidase b (mao b) in complex with pioglitazone
    34% identity, 90% coverage of query (249 bits)

3po7A Human monoamine oxidase b in complex with zonisamide
    34% identity, 90% coverage of query (249 bits)

2xcgA Tranylcypromine-inhibited human monoamine oxidase b in complex with 2- (2-benzofuranyl)-2-imidazoline
    34% identity, 90% coverage of query (249 bits)

2vz2A Human mao b in complex with mofegiline
    34% identity, 90% coverage of query (249 bits)

2vrmA Structure of human mao b in complex with phenyethylhydrazine
    34% identity, 90% coverage of query (249 bits)

2v61A Structure of human mao b in complex with the selective inhibitor 7-(3- chlorobenzyloxy)-4-(methylamino)methyl-coumarin
    34% identity, 90% coverage of query (249 bits)

2v60A Structure of human mao b in complex with the selective inhibitor 7-(3- chlorobenzyloxy)-4-carboxaldehyde-coumarin
    34% identity, 90% coverage of query (249 bits)

2v5zA Structure of human mao b in complex with the selective inhibitor safinamide
    34% identity, 90% coverage of query (249 bits)

2c70A Functional role of the aromatic cage in human monoamine oxidase b: structures and catalytic properties of tyr435 mutant proteins
    34% identity, 90% coverage of query (249 bits)

2c67A Mao inhibition by rasagiline analogues
    34% identity, 90% coverage of query (249 bits)

2c66A Mao inhibition by rasagiline analogues
    34% identity, 90% coverage of query (249 bits)

2c65A Mao inhibition by rasagiline analogues
    34% identity, 90% coverage of query (249 bits)

2bybA Human monoamine oxidase b in complex with deprenyl
    34% identity, 90% coverage of query (249 bits)

2bk3A Human monoamine oxidase b in complex with farnesol
    34% identity, 90% coverage of query (249 bits)

1s3eA Crystal structure of maob in complex with 6-hydroxy-n-propargyl-1(r)- aminoindan
    34% identity, 90% coverage of query (249 bits)

1s3bA Crystal structure of maob in complex with n-methyl-n-propargyl-1(r)- aminoindan
    34% identity, 90% coverage of query (249 bits)

1s2yA Crystal structure of maob in complex with n-propargyl-1(s)-aminoindan
    34% identity, 90% coverage of query (249 bits)

1s2qA Crystal structure of maob in complex with n-propargyl-1(r)-aminoindan (rasagiline)
    34% identity, 90% coverage of query (249 bits)

1ojcA Human monoamine oxidase b in complex with n-(2-aminoethyl)-p- chlorobenzamide
    34% identity, 90% coverage of query (249 bits)

1ojaA Human monoamine oxidase b in complex with isatin
    34% identity, 90% coverage of query (249 bits)

1oj9A Human monoamine oxidase b in complex with 1,4-diphenyl-2-butene
    34% identity, 90% coverage of query (249 bits)

6fvzA / P27338 Crystal structure of human monoamine oxidase b (mao b) in complex with dimethylphenyl-chromone-carboxamide (see paper)
    34% identity, 90% coverage of query (248 bits)

1gosA Human monoamine oxidase b
    34% identity, 90% coverage of query (248 bits)

7zw3AAA Amine oxidase [flavin-containing] B
    34% identity, 90% coverage of query (248 bits)

6yt2A Crystal structure of human monoamine oxidase b in complex with diphenylene iodonium (dpi)
    34% identity, 90% coverage of query (248 bits)

6fw0A Crystal structure of human monoamine oxidase b (mao b) in complex with chlorophenyl-chromone-carboxamide
    34% identity, 90% coverage of query (248 bits)

2c64B Mao inhibition by rasagiline analogues
    34% identity, 90% coverage of query (248 bits)

2bxrA Human monoamine oxidase a in complex with clorgyline, crystal form a
    33% identity, 89% coverage of query (246 bits)

Maoa / P21396 monoamine oxidase A subunit (EC 1.4.3.4) from Rattus norvegicus (see 4 papers)
AOFA_RAT / P21396 Amine oxidase [flavin-containing] A; Monoamine oxidase type A; MAO-A; EC 1.4.3.21; EC 1.4.3.4 from Rattus norvegicus (Rat) (see 4 papers)
P21396 monoamine oxidase (EC 1.4.3.4) from Rattus norvegicus (see 29 papers)
    33% identity, 87% coverage of query (244 bits)

M5AWH1 cyclohexylamine oxidase (EC 1.4.3.12) from Microbacterium oxydans (see paper)
    35% identity, 89% coverage of query (244 bits)

4i58A / R4GRV2 Cyclohexylamine oxidase from brevibacterium oxydans ih-35a (see paper)
    35% identity, 89% coverage of query (243 bits)

3rhaA / A1R0W1 The crystal structure of oxidoreductase from arthrobacter aurescens
    33% identity, 90% coverage of query (243 bits)

2yg3B / B0F9F6 Structure-based redesign of cofactor binding in putrescine oxidase: wild type enzyme (see paper)
    33% identity, 89% coverage of query (224 bits)

2yg4A Structure-based redesign of cofactor binding in putrescine oxidase: wild type bound to putrescine
    33% identity, 89% coverage of query (224 bits)

puo / P40974 putrescine oxidase subunit (EC 1.4.3.10) from Kocuria rosea (see 2 papers)
    34% identity, 89% coverage of query (223 bits)

6lqcA Crystal structure of cyclohexylamine oxidase from erythrobacteraceae bacterium (see paper)
    32% identity, 89% coverage of query (200 bits)

6lqlA Complex structure of chao with product from erythrobacteraceae bacterium
    32% identity, 89% coverage of query (200 bits)

8i6iA / A0A2A5PFR1 Crystal structure of cyclohexylamine oxidase from acinetobacter sp. Yt-02
    31% identity, 89% coverage of query (199 bits)

Build an alignment

Build an alignment for WP_110206665.1 and 67 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

P72346 L-amino-acid oxidase (EC 1.4.3.2); L-arginine oxidase (EC 1.4.3.25) from Synechococcus elongatus PCC 6301 (see paper)
    26% identity, 90% coverage of query (89.7 bits)

A1IGW6 L-amino-acid oxidase (EC 1.4.3.2) from Sebastes schlegelii (see paper)
    23% identity, 90% coverage of query (85.9 bits)

OXLA_HUMAN / Q96RQ9 L-amino-acid oxidase; LAAO; LAO; Interleukin-4-induced protein 1; IL4-induced protein 1; hIL4I1; Protein Fig-1; hFIG1; EC 1.4.3.2; EC 1.4.3.25 from Homo sapiens (Human) (see 13 papers)
    25% identity, 89% coverage of query (84.0 bits)

M4T5L3 nicotine dehydrogenase (EC 1.5.99.4) from Pseudomonas sp. (see paper)
    27% identity, 99% coverage of query (84.0 bits)

OXLA_MICMP / A0A2U8QPE6 L-amino acid oxidase; LAO; MipLAAO1; EC 1.4.3.2 from Micrurus mipartitus (Red-tailed coral snake) (see 2 papers)
A0A2U8QPE6 L-amino-acid oxidase (EC 1.4.3.2) from Micrurus mipartitus (see paper)
    25% identity, 89% coverage of query (83.6 bits)

5z2gA / A8QL58 Crystal structure of l-amino acid oxidase from venom of naja atra
    23% identity, 89% coverage of query (83.6 bits)

OXLA_NAJAT / A8QL58 L-amino-acid oxidase; LAO; NA-LAAO; EC 1.4.3.2 from Naja atra (Chinese cobra) (see paper)
    23% identity, 89% coverage of query (83.2 bits)

3nn6X Crystal structure of inhibitor-bound in active centre 6-hydroxy-l- nicotine oxidase from arthrobacter nicotinovorans
    25% identity, 89% coverage of query (82.0 bits)

3nn0X Complex of 6-hydroxy-l-nicotine oxidase with nicotinamide
    25% identity, 89% coverage of query (82.0 bits)

3nk2X Complex of 6-hydroxy-l-nicotine oxidase with dopamine
    25% identity, 89% coverage of query (82.0 bits)

3nk1X Complex of 6-hydroxy-l-nicotine oxidase with serotonin
    25% identity, 89% coverage of query (82.0 bits)

3nh3X Complex of 6-hydroxy-l-nicotine oxidase with final ketone product formed during catalytic turnover
    25% identity, 89% coverage of query (82.0 bits)

3ngcX Complex of 6-hydroxy-l-nicotine oxidase with intermediate methylmyosmine product formed during catalytic turnover
    25% identity, 89% coverage of query (82.0 bits)

3k7mX Crystal structure of 6-hydroxy-l-nicotine oxidase from arthrobacter nicotinovorans
    25% identity, 89% coverage of query (82.0 bits)

6-HLNO / Q93NH4 (S)-6-hydroxynicotine oxidase monomer (EC 1.5.3.5) from Paenarthrobacter nicotinovorans (see 5 papers)
HLNO_PAENI / Q93NH4 (S)-6-hydroxynicotine oxidase; 6-hydroxy-L-nicotine oxidase; 6-HLNO; L-6-hydroxynicotine oxidase; L-hydroxynicotine oxidase; LHNO; EC 1.5.3.5 from Paenarthrobacter nicotinovorans (Arthrobacter nicotinovorans) (see 8 papers)
Q93NH4 (S)-6-hydroxynicotine oxidase (EC 1.5.3.5); 6-hydroxypseudooxynicotine dehydrogenase (EC 1.5.99.14); nicotine dehydrogenase (EC 1.5.99.4) from Paenarthrobacter nicotinovorans (see 3 papers)
AAK64245.1 6-hydroxy-L-nicotine oxidase from Paenarthrobacter nicotinovorans (see paper)
    25% identity, 89% coverage of query (82.0 bits)

3ng7X / Q93NH4 Complex of dithionite-reduced 6-hydroxy-l-nicotine oxidase with substrate bound at active site and inhibitor at exit cavity (see paper)
    25% identity, 89% coverage of query (81.6 bits)

OXLA_ECHOC / B5U6Y8 L-amino-acid oxidase; LAAO; LAO; EC 1.4.3.2 from Echis ocellatus (Ocellated saw-scaled viper) (see paper)
    23% identity, 90% coverage of query (80.5 bits)

A0A0C6EYL8 L-amino-acid oxidase (EC 1.4.3.2) from Gadus morhua (see paper)
    24% identity, 90% coverage of query (79.3 bits)

D2KWB6 L-amino-acid oxidase (EC 1.4.3.2) from Platichthys stellatus (see 3 papers)
    22% identity, 89% coverage of query (75.1 bits)

P46882 monoamine oxidase (EC 1.4.3.4) from Aspergillus niger (see paper)
    25% identity, 90% coverage of query (72.4 bits)

2vvmA / P46882 The structure of mao-n-d5, a variant of monoamine oxidase from aspergillus niger. (see paper)
    25% identity, 90% coverage of query (71.2 bits)

OXLA_VIPAA / P0DI84 L-amino-acid oxidase; LAO; VAA-LAAO I; EC 1.4.3.2 from Vipera ammodytes ammodytes (Western sand viper) (see 2 papers)
3kveA / P0DI84 Structure of native l-amino acid oxidase from vipera ammodytes ammodytes: stabilization of the quaternary structure by divalent ions and structural changes in the dynamic active site
    22% identity, 89% coverage of query (71.2 bits)

OXLA_DABRR / G8XQX1 L-amino-acid oxidase; DrLAO; LAAO; EC 1.4.3.2 from Daboia russelii (Russel's viper) (Vipera russelii) (see paper)
G8XQX1 L-amino-acid oxidase (EC 1.4.3.2) from Daboia russelii (see paper)
    22% identity, 89% coverage of query (70.9 bits)

B5U982 L-amino-acid oxidase (EC 1.4.3.2) from Myoxocephalus polyacanthocephalus (see paper)
    22% identity, 90% coverage of query (70.5 bits)

MPAO / O64411 polyamine oxidase (propane-1,3-diamine forming) (EC 1.5.3.14) from Zea mays (see 3 papers)
PAO1_MAIZE / O64411 Polyamine oxidase 1; EC 1.5.3.14; EC 1.5.3.15 from Zea mays (Maize) (see 2 papers)
O64411 polyamine oxidase (propane-1,3-diamine-forming) (EC 1.5.3.14) from Zea mays (see 8 papers)
    24% identity, 91% coverage of query (70.5 bits)

rebO / Q8KHS0 7-chloro-L-tryptophan oxidase monomer (EC 1.4.3.23) from Lentzea aerocolonigenes (see 3 papers)
REBO_LENAE / Q8KHS0 Flavin-dependent L-tryptophan oxidase RebO; L-amino acid oxidase protein; L-AAO; EC 1.4.3.23 from Lentzea aerocolonigenes (Lechevalieria aerocolonigenes) (Saccharothrix aerocolonigenes) (see 4 papers)
Q8KHS0 7-chloro-L-tryptophan oxidase (EC 1.4.3.23) from Lentzea aerocolonigenes (see 2 papers)
    24% identity, 88% coverage of query (69.7 bits)

1h84A Covalent adduct between polyamine oxidase and n1ethyln11((cycloheptyl)methyl)4,8diazaundecane at ph 4.6
    24% identity, 89% coverage of query (69.7 bits)

1h83A Structure of polyamine oxidase in complex with 1,8-diaminooctane
    24% identity, 89% coverage of query (69.7 bits)

1h82A Structure of polyamine oxidase in complex with guazatine
    24% identity, 89% coverage of query (69.7 bits)

1b5qA A 30 angstrom u-shaped catalytic tunnel in the crystal structure of polyamine oxidase
    24% identity, 89% coverage of query (69.7 bits)

OXLA_SIGCA / P86810 L-amino-acid oxidase; Antiparasitic protein; APP; Serum L-amino-acid oxidase; SR-LAAO; EC 1.4.3.2 from Siganus canaliculatus (White-spotted spinefoot) (Chaetodon canaliculatus) (see 2 papers)
P86810 L-amino-acid oxidase (EC 1.4.3.2) from Siganus canaliculatus (see 2 papers)
    23% identity, 90% coverage of query (69.3 bits)

PAO6_ORYSJ / A0A0P0XM10 Polyamine oxidase 6; OsPAO6; Polyamine oxidase B; EC 1.5.3.- from Oryza sativa subsp. japonica (Rice) (see 2 papers)
    24% identity, 89% coverage of query (68.6 bits)

PAO4_ORYSJ / Q7XR46 Polyamine oxidase 4; OsPAO4; EC 1.5.3.- from Oryza sativa subsp. japonica (Rice) (see paper)
    23% identity, 92% coverage of query (68.2 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory