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Searching for up to 100 curated homologs for WP_110751443.1 NCBI__GCF_003217235.1:WP_110751443.1 (438 a.a.)

Found high-coverage hits (≥70%) to 52 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

4ryaA / B9JRF8 Crystal structure of abc transporter solute binding protein avi_3567 from agrobacterium vitis s4, target efi-510645, with bound d-mannitol
    82% identity, 95% coverage of query (716 bits)

TC 3.A.1.1.5 / O30831 SmoE, component of Hexitol (glucitol; mannitol) porter from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
    72% identity, 100% coverage of query (643 bits)

PGA1_c13210 ABC transporter for D-Sorbitol, periplasmic substrate-binding component from Phaeobacter inhibens BS107
    68% identity, 100% coverage of query (615 bits)

mtlE / Q4KC57 polyol ABC-type transporter periplasmic substrate-binding protein from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see paper)
    61% identity, 99% coverage of query (553 bits)

PS417_12715 ABC transporter for D-Mannitol and D-Sorbitol, periplasmic substrate-binding protein from Pseudomonas simiae WCS417
    61% identity, 99% coverage of query (545 bits)

Pf6N2E2_1963 ABC transporter for D-sorbitol, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E2
    59% identity, 100% coverage of query (545 bits)

AO356_00025 ABC transporter for D-Sorbitol, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2C3
    59% identity, 100% coverage of query (545 bits)

TC 3.A.1.1.49 / O30491 MtlE, component of The polyol (mannitol, glucitol (sorbitol), arabitol (arabinitol; lyxitol)) uptake porter, MtlEFGK from Pseudomonas fluorescens
    60% identity, 100% coverage of query (541 bits)

Ac3H11_2944 ABC transporter for D-Sorbitol, periplasmic substrate-binding component from Acidovorax sp. GW101-3H11
    61% identity, 96% coverage of query (529 bits)

MANBP_PSEAE / Q9I1E0 Mannitol-binding protein from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    60% identity, 95% coverage of query (526 bits)

BPHYT_RS16115 ABC transporter for D-Sorbitol, periplasmic substrate-binding component from Burkholderia phytofirmans PsJN
    58% identity, 100% coverage of query (519 bits)

HSERO_RS17000 ABC transporter for D-sorbitol/xylitol, substrate-binding component from Herbaspirillum seropedicae SmR1
    33% identity, 75% coverage of query (135 bits)

Build an alignment

Build an alignment for WP_110751443.1 and 12 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

5iaiA / B9JM84 Crystal structure of abc transporter solute binding protein arad_9887 from agrobacterium radiobacter k84, target efi-510945 in complex with ribitol
    29% identity, 92% coverage of query (120 bits)

TC 3.A.1.1.7 / O51923 MalE aka PF1739, component of Maltose/trehalose porter (see paper)
    26% identity, 87% coverage of query (103 bits)

1eu8A / Q7LYW7 Structure of trehalose maltose binding protein from thermococcus litoralis (see paper)
    26% identity, 89% coverage of query (103 bits)

MALE_THELN / Q7LYW7 Trehalose/maltose-binding protein MalE; TMBP from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see 4 papers)
    26% identity, 89% coverage of query (101 bits)

7qhvAAA / A9CEY9 7qhvAAA (see paper)
    25% identity, 88% coverage of query (99.0 bits)

smoF / A9CEY9 3-(6-sulfo-α-D-quinovosyl)-sn-glycerol binding protein from Agrobacterium fabrum (strain C58 / ATCC 33970) (see paper)
SMOF_AGRFC / A9CEY9 Sulfoquinovosyl glycerol-binding protein SmoF; SQGro-binding protein SmoF; SQ monooxygenase cluster protein F from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see 2 papers)
    24% identity, 97% coverage of query (97.8 bits)

7ofyA Crystal structure of sq binding protein from agrobacterium tumefaciens in complex with sulfoquinovosyl glycerol (sqgro)
    25% identity, 88% coverage of query (96.3 bits)

7yzuA Crystal structure of the sulfoquinovosyl binding protein smof complexed with sqme
    25% identity, 88% coverage of query (96.3 bits)

7yzsAAA Sulfoquinovosyl binding protein
    25% identity, 88% coverage of query (96.3 bits)

6dtqA / G4FGN8 Maltose bound t. Maritima male3 (see paper)
    27% identity, 88% coverage of query (95.9 bits)

TC 3.A.1.1.41 / G4FGN8 Extracellular solute-binding protein family 1, component of Trehalose porter. Also binds sucrose (Boucher and Noll, 2011). Induced by glucose and trehalose. Directly regulated by trehalose-responsive regulator TreR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    27% identity, 88% coverage of query (95.9 bits)

8s5bA Sulfoquinovosyl glycerol-binding protein SmoF
    25% identity, 88% coverage of query (94.4 bits)

SM_b21221 ABC transporter for D-Glucosamine, periplasmic substrate-binding protein from Sinorhizobium meliloti 1021
    28% identity, 97% coverage of query (94.0 bits)

3jzjA / B0B0V1 Crystal structures of the gach receptor of streptomyces glaucescens gla.O in the unliganded form and in complex with acarbose and an acarbose homolog. Comparison with acarbose-loaded maltose binding protein of salmonella typhimurium. (see paper)
    27% identity, 74% coverage of query (87.4 bits)

3k02A Crystal structures of the gach receptor of streptomyces glaucescens gla.O in the unliganded form and in complex with acarbose and an acarbose homolog. Comparison with acarbose-loaded maltose binding protein of salmonella typhimurium.
    27% identity, 74% coverage of query (87.4 bits)

5ci5A / A8F7X5 Crystal structure of an abc transporter solute binding protein from thermotoga lettingae tmo (tlet_1705, target efi-510544) bound with alpha-d-tagatose
    25% identity, 82% coverage of query (86.3 bits)

5ysdB / Q92AS8 Crystal structure of beta-1,2-glucooligosaccharide binding protein in complex with sophorotriose (see paper)
    27% identity, 77% coverage of query (75.5 bits)

5ysdA Crystal structure of beta-1,2-glucooligosaccharide binding protein in complex with sophorotriose
    27% identity, 77% coverage of query (75.5 bits)

5ysbA Crystal structure of beta-1,2-glucooligosaccharide binding protein in ligand-free form
    27% identity, 77% coverage of query (75.5 bits)

ELTP_MYCS2 / A0QXD9 Erythritol/L-threitol-binding protein from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
    23% identity, 73% coverage of query (75.1 bits)

Q92AS8 ABC-type beta-glucan transporter (EC 7.5.2.3) from Listeria innocua (see paper)
    27% identity, 77% coverage of query (75.1 bits)

TC 3.A.1.1.44 / Q7AKP1 Putative maltose-binding protein, component of MalEFG (K unknown), involved in maltose and maltodextrin uptake from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    25% identity, 88% coverage of query (74.7 bits)

8artB / C9ZHD5 Abc transporter binding protein male from streptomyces scabiei in complex with maltose
    27% identity, 88% coverage of query (72.4 bits)

TC 3.A.1.1.19 / Q8L126 PalE, component of Platinose (isomaltulose) (6-O-α-D-glucopyranosyl-D-fructofuranose) porter from Agrobacterium tumefaciens (see 3 papers)
palE / BAB96538.1 PalE from Agrobacterium tumefaciens (see 3 papers)
    26% identity, 82% coverage of query (71.6 bits)

Dshi_0547 ABC transporter for Xylitol, periplasmic substrate-binding component from Dinoroseobacter shibae DFL-12
    25% identity, 84% coverage of query (71.2 bits)

SM_b21103 ABC transporter for L-Fucose, periplasmic substrate-binding protein from Sinorhizobium meliloti 1021
    26% identity, 83% coverage of query (70.9 bits)

5f7vA / Q8YAE9 Abc substrate-binding protein lmo0181 from listeria monocytogenes in complex with cycloalternan (see paper)
    23% identity, 88% coverage of query (59.7 bits)

TC 3.A.1.1.33 / Q8KN19 Putative sugar transporter sugar-binding protein, component of The N,N'-diacetylchitobiose uptake transporter, DasABC/MsiK (MsiK energizes several ABC transporters (see 3.A.1.1.23)) from Streptomyces sp. 139 (see 2 papers)
    23% identity, 72% coverage of query (55.1 bits)

7ehpA Chitin oligosaccharide binding protein (see paper)
    22% identity, 72% coverage of query (53.5 bits)

TC 3.A.1.1.25 / Q72H68 Trehalose/maltose-binding protein aka TT_C1627, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (see paper)
    21% identity, 72% coverage of query (52.8 bits)

6preA / A0A0H2URJ7 Sbp rafe in complex with verbascose (see paper)
    24% identity, 75% coverage of query (52.8 bits)

6jahA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with glucose
    21% identity, 72% coverage of query (52.8 bits)

6jagA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with sucrose
    21% identity, 72% coverage of query (52.8 bits)

6jadA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with palatinose
    21% identity, 72% coverage of query (52.8 bits)

6j9yA Crystal structure of abc transporter alpha-glycoside-binding protein in complex with maltose
    21% identity, 72% coverage of query (52.8 bits)

2i58A Crystal structure of rafe from streptococcus pneumoniae complexed with raffinose
    24% identity, 75% coverage of query (52.8 bits)

DASA_STRCO / Q9K491 Diacetylchitobiose binding protein DasA from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see 2 papers)
    24% identity, 72% coverage of query (52.0 bits)

6jaiA Crystal structure of abc transporter alpha-glycoside-binding mutant protein d118a in complex with maltose
    21% identity, 72% coverage of query (52.0 bits)

6jamA / Q5SLD7 Crystal structure of abc transporter alpha-glycoside-binding mutant protein r356a in complex with trehalose (see paper)
    21% identity, 72% coverage of query (51.6 bits)

6jb0A Crystal structure of abc transporter alpha-glycoside-binding mutant protein w287a in complex with trehalose
    21% identity, 72% coverage of query (47.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory