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Searching for up to 100 curated homologs for WP_147050548.1 NCBI__GCF_001482365.1:WP_147050548.1 (317 a.a.)

Found high-coverage hits (≥70%) to 40 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

DRRA_STRPE / P32010 Daunorubicin/doxorubicin resistance ATP-binding protein DrrA; EC 7.6.2.- from Streptomyces peucetius (see 2 papers)
P32010 ABC-type xenobiotic transporter (EC 7.6.2.2) from Streptomyces peucetius (see paper)
TC 3.A.1.105.1 / P32010 DrrA, component of Daunorubicin, doxorubicin etc. (multidrug resistance) exporter, DrrAB from Streptomyces peucetius (see 2 papers)
    35% identity, 92% coverage of query (153 bits)

TC 3.A.1.105.8 / Q7UE58 ABC-type multidrug transport system, ATPase component, component of ABC-2 transporter from Rhodopirellula baltica (strain SH1)
    34% identity, 100% coverage of query (144 bits)

nodI / GB|AAB16898.1 nodulation ATP-binding protein I from Rhizobium sp. N33 (see paper)
    35% identity, 95% coverage of query (141 bits)

4yerA / Q9X1C3 Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
    31% identity, 99% coverage of query (141 bits)

TC 3.A.1.105.2 / Q53716 OleC4, component of Oleandomycin (drug resistance) exporter from Streptomyces antibioticus (see paper)
    33% identity, 99% coverage of query (137 bits)

TC 3.A.1.102.1 / P50332 NodI, component of Lipooligosaccharide exporter (nodulation proteins, NodIJ) from Rhizobium galegae (see paper)
    35% identity, 91% coverage of query (129 bits)

MEATP_MYCTU / O86311 Multidrug efflux system ATP-binding protein Rv1218c; EC 7.6.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
    36% identity, 71% coverage of query (129 bits)

8k1oB / O86311 Mycobacterial efflux pump, amppnp bound state
    36% identity, 70% coverage of query (128 bits)

8k1pB Mycobacterial efflux pump, adp+vanadate bound state
    36% identity, 70% coverage of query (128 bits)

Build an alignment

Build an alignment for WP_147050548.1 and 9 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

LNRL_BACSU / P94440 Linearmycin resistance ATP-binding protein LnrL; EC 7.6.2.- from Bacillus subtilis (strain 168) (see 2 papers)
    28% identity, 91% coverage of query (127 bits)

FLQE1_MYCTU / P9WQL7 Fluoroquinolones export ATP-binding protein Rv2688c; EC 7.6.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    32% identity, 91% coverage of query (125 bits)

sagG / GI|23305059 ABC transporter, ATP-binding protein SagG from Streptococcus iniae (see paper)
    27% identity, 100% coverage of query (125 bits)

TC 3.A.1.211.3 / Q9BZC7 Multidrug resistance pump, ABCA2 (ABC2) from Homo sapiens (Human) (see 6 papers)
ABCA2 / GI|55962682 ATP-binding cassette sub-family A member 2 from Homo sapiens
    34% identity, 70% coverage of query (124 bits)

ABCA2_HUMAN / Q9BZC7 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Homo sapiens (Human) (see 10 papers)
    34% identity, 70% coverage of query (124 bits)

TC 3.A.1.132.1 / O30489 GldA, component of The GldAFG putative ABC transporter required for ratchet-type gliding motility; may function in secretion of a macromolecule such as an exopolysaccharide. (Agarwal et al., 1997; Hunnicutt et al., 2002; McBride and Zhu 2013). Soluble GldG homologues (no TMSs) are found in eukaryotes (e.g. intraflagellar protein transporter, IPT52 of Chlamydomonas reinhardtii; XP_001692161) from Cytophaga johnsonae (Flavobacterium johnsoniae) (see paper)
    28% identity, 91% coverage of query (122 bits)

ABCA2_MOUSE / P41234 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Mus musculus (Mouse) (see 5 papers)
    33% identity, 70% coverage of query (120 bits)

ABCA2_RAT / Q9ESR9 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Rattus norvegicus (Rat) (see 6 papers)
    30% identity, 71% coverage of query (105 bits)

ECFA2_STRT2 / Q5M244 Energy-coupling factor transporter ATP-binding protein EcfA2; ECF transporter A component EcfA2; EC 3.6.3.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
TC 3.A.1.25.6 / Q5M244 Energy-coupling factor transporter ATP-binding protein EcfA 1, component of Riboflavin ECF transport system, EcfAA'T/RibU from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
    31% identity, 75% coverage of query (104 bits)

ABCA4_BOVIN / F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 11 papers)
    29% identity, 71% coverage of query (100 bits)

ABCA9_HUMAN / Q8IUA7 ATP-binding cassette sub-family A member 9; EC 7.6.2.- from Homo sapiens (Human) (see paper)
TC 3.A.1.211.16 / Q8IUA7 ATP-binding cassette sub-family A member 9, ABCA9 of 1624 aas. May play a role in monocyte differentiation and lipid homeostasis. Expressed in fetal tissues with highest expression in fetal heart and kidney. Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages from Homo sapiens
    33% identity, 91% coverage of query (100 bits)

1g6hA / Q58663 Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
    26% identity, 75% coverage of query (100 bits)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter
    26% identity, 75% coverage of query (99.0 bits)

ABCA9_MOUSE / Q8K449 ATP-binding cassette sub-family A member 9; EC 7.6.2.- from Mus musculus (Mouse) (see 3 papers)
    32% identity, 91% coverage of query (98.6 bits)

1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
    30% identity, 74% coverage of query (97.8 bits)

ABCA6_HUMAN / Q8N139 ATP-binding cassette sub-family A member 6; EC 7.6.2.- from Homo sapiens (Human) (see 3 papers)
TC 3.A.1.211.15 / Q8N139 ATP-binding cassette sub-family A member 6, ABCA6 of 1617 aas. This transporter may play a role in macrophage lipid homeostasis. It is up-regulated during monocyte differentiation into macrophages but down-regulated by cholesterol loading of macrophages from Homo sapiens
    30% identity, 91% coverage of query (96.7 bits)

MDR3_HUMAN / P21439 Phosphatidylcholine translocator ABCB4; ATP-binding cassette sub-family B member 4; Multidrug resistance protein 3; P-glycoprotein 3; EC 7.6.2.1 from Homo sapiens (Human) (see 28 papers)
TC 3.A.1.201.3 / P21439 Short chain fatty acid phosphatidylcholine translocase (phospholipid flippase), MDR3; AbcB4; Pgy3 from Homo sapiens (Human) (see 15 papers)
    31% identity, 75% coverage of query (94.7 bits)

7ahhC Opua inhibited inward-facing, sbd docked
    27% identity, 72% coverage of query (89.4 bits)

7aheC / Q9KIF7 Opua inhibited inward facing (see paper)
    27% identity, 72% coverage of query (89.4 bits)

WHITE_DROME / P10090 Protein white; ATP-binding cassette transporter sub-family G member white; Broad substrate specificity ATP-binding cassette transporter white; EC 7.6.2.-; EC 7.6.2.6 from Drosophila melanogaster (Fruit fly) (see 12 papers)
TC 3.A.1.204.1 / P10090 Eye pigment precursor transporter, White from Drosophila melanogaster (Fruit fly) (see 8 papers)
w / RF|NP_476787.1 protein white from Drosophila melanogaster
    31% identity, 72% coverage of query (89.0 bits)

RbsA / b3749 ribose ABC transporter ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 5 papers)
RbsA / P04983 ribose ABC transporter ATP binding subunit from Escherichia coli (strain K12) (see 2 papers)
RBSA_ECOLI / P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.2.1 / P04983 RbsA aka B3749, component of Ribose porter from Escherichia coli (see 6 papers)
rbsA / GB|AAC76772.1 ribose transport, ATP-binding protein RbsA; EC 3.6.3.17 from Escherichia coli K12 (see 7 papers)
    27% identity, 73% coverage of query (87.0 bits)

8t1pD Heterodimeric abc transporter bmrcd in the occluded conformation bound to adpvi: bmrcd_oc-adpvi
    28% identity, 72% coverage of query (78.2 bits)

8hprC Lpqy-sugabc in state 4
    28% identity, 72% coverage of query (78.2 bits)

8hprD Lpqy-sugabc in state 4
    28% identity, 72% coverage of query (78.2 bits)

6xjiC / X5EJW5 Pmtcd abc exporter at c1 symmetry (see paper)
    22% identity, 87% coverage of query (77.4 bits)

8fpfD / O07549 Heterodimeric abc transporter bmrcd in the inward-facing conformation bound to atp: bmrcd_if-atp (see paper)
    28% identity, 72% coverage of query (77.4 bits)

8fmvD Heterodimeric abc transporter bmrcd in the inward-facing conformation bound to substrate and atp: bmrcd_if-2ht/atp
    28% identity, 72% coverage of query (77.4 bits)

5lj7A / Q2EHL8 Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
    25% identity, 74% coverage of query (73.6 bits)

7dv5U / O95342 Human bile salt exporter abcb11 in complex with taurocholate (see paper)
    28% identity, 89% coverage of query (72.8 bits)

8pmjA / O95342 Vanadate-trapped bsep in nanodiscs (see paper)
    27% identity, 89% coverage of query (63.9 bits)

3ozxA Crystal structure of abce1 of sulfolubus solfataricus (-fes domain)
    24% identity, 70% coverage of query (55.8 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory