Sites on a Tree

 

Searching for up to 100 curated homologs for WP_157499288.1 NCBI__GCF_000769915.1:WP_157499288.1 (263 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

lvr / Q9LBG2 levodione reductase monomer from Leifsonia aquatica (see 3 papers)
lvr / BAA95121.1 levodione reductase from Leifsonia aquatica (see paper)
    47% identity, 98% coverage of query (253 bits)

1iy8A / Q9LBG2 Crystal structure of levodione reductase (see paper)
    47% identity, 98% coverage of query (253 bits)

Q9LBG2 Levodione reductase; (6R)-2,2,6-trimethyl-1,4-cyclohexanedione reductase; EC 1.1.1.- from Leifsonia aquatica (Corynebacterium aquaticum)
    47% identity, 98% coverage of query (253 bits)

6ixmC / X2D0L0 Crystal structure of the ketone reductase chkred20 from the genome of chryseobacterium sp. Ca49 complexed with NAD (see paper)
    40% identity, 96% coverage of query (177 bits)

4nbuB Crystal structure of fabg from bacillus sp (see paper)
    41% identity, 97% coverage of query (176 bits)

A0A1E3M3N6 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) from Acinetobacter baumannii (see paper)
6zzsD / A0A1E3M3N6 Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and 3-oxovalerate (see paper)
    36% identity, 96% coverage of query (167 bits)

4fn4A / Q4J9F2 Short-chain NAD(h)-dependent dehydrogenase/reductase from sulfolobus acidocaldarius (see paper)
    36% identity, 98% coverage of query (167 bits)

Q4J9F2 alcohol dehydrogenase (EC 1.1.1.1) from Sulfolobus acidocaldarius (see 2 papers)
    36% identity, 98% coverage of query (167 bits)

6zzqA Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and acetoacetate
    36% identity, 96% coverage of query (167 bits)

5b4tA / D0VWQ0 Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and a substrate d-3- hydroxybutyrate (see paper)
    35% identity, 97% coverage of query (163 bits)

3w8dA Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and an inhibitor methylmalonate
    35% identity, 97% coverage of query (163 bits)

3vdrA Crystal structure of d-3-hydroxybutyrate dehydrogenase, prepared in the presence of the substrate d-3-hydroxybutyrate and NAD(+)
    35% identity, 97% coverage of query (163 bits)

3vdqA Crystal structure of alcaligenes faecalis d-3-hydroxybutyrate dehydrogenase in complex with NAD(+) and acetate
    35% identity, 97% coverage of query (163 bits)

Q9AE70 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) from Pseudomonas putida (see 2 papers)
    35% identity, 97% coverage of query (162 bits)

2q2qD / Q9AE70 Structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas putida (see paper)
    35% identity, 96% coverage of query (162 bits)

YfeF / b2426 oxidoreductase UcpA (EC 1.1.1.304) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
ucpA / P37440 oxidoreductase UcpA (EC 1.1.1.304) from Escherichia coli (strain K12) (see 6 papers)
    38% identity, 97% coverage of query (160 bits)

6qheA / A0A545BBS8 Alcohol dehydrogenase from arthrobacter sp. Ts-15 in complex with NAD+
    38% identity, 97% coverage of query (159 bits)

A0A545BBS8 pseudoephedrine dehydrogenase (EC 1.1.1.422) from Arthrobacter sp. TS-15 (see paper)
    38% identity, 97% coverage of query (159 bits)

ABA4_BOTFU / Q14RS1 Short-chain dehydrogenase/reductase aba4; Abscisic acid biosynthesis cluster protein 4; EC 1.1.1.- from Botryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea) (see 3 papers)
    38% identity, 95% coverage of query (158 bits)

ABA4_BOTFB / A0A384JQF5 Short-chain dehydrogenase/reductase aba4; Abscisic acid biosynthesis cluster protein 4; EC 1.1.1.- from Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea) (see 3 papers)
    39% identity, 95% coverage of query (158 bits)

8y83A / A0A562MSV3 Crystal structure of a ketoreductase from sphingobacterium siyangense sy1 with co-enzyme (see paper)
    38% identity, 97% coverage of query (158 bits)

Pf1N1B4_412 L-arabinose 1-dehydrogenase / D-galactose 1-dehydrogenase (EC 1.1.1.46; EC 1.1.1.48) from Pseudomonas fluorescens FW300-N1B4
    36% identity, 98% coverage of query (157 bits)

PfGW456L13_2119 L-arabinose 1-dehydrogenase / D-galactose 1-dehydrogenase (EC 1.1.1.46; EC 1.1.1.48) from Pseudomonas fluorescens GW456-L13
    35% identity, 98% coverage of query (155 bits)

Pf6N2E2_5967 L-arabinose 1-dehydrogenase / D-galactose 1-dehydrogenase (EC 1.1.1.46; EC 1.1.1.48) from Pseudomonas fluorescens FW300-N2E2
    35% identity, 98% coverage of query (155 bits)

LINC_SPHIU / D4YYG1 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase; 2,5-DDOL dehydrogenase; EC 1.1.1.- from Sphingobium indicum (strain DSM 16413 / CCM 7287 / MTCC 6362 / UT26 / NBRC 101211 / UT26S) (Sphingobium japonicum) (see paper)
    34% identity, 97% coverage of query (155 bits)

chnA / Q9F7E0 cyclohexanol dehydrogenase (EC 1.1.1.245) from Acinetobacter sp. (strain SE19) (see 4 papers)
CHNA_ACISS / Q9F7E0 Cyclohexanol dehydrogenase; EC 1.1.1.245 from Acinetobacter sp. (strain SE19) (see paper)
    38% identity, 95% coverage of query (155 bits)

Q5KST5 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) from Pseudomonas fragi (see 3 papers)
1wmbA / Q5KST5 Crystal structure of NAD dependent d-3-hydroxybutylate dehydrogenase (see paper)
BAD86668.1 D(-)-3-hydroxybutyrate dehydrogenase from Pseudomonas fragi (see paper)
    33% identity, 97% coverage of query (154 bits)

7pcsB / Q9KJF1 Structure of the heterotetrameric sdr family member bbscd (see paper)
    36% identity, 98% coverage of query (154 bits)

BBSD_THAAR / Q9KJF1 (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA dehydrogenase subunit BbsD; (S,R)-2-(alpha-hydroxybenzyl)succinyl-CoA dehydrogenase subunit BbsD; EC 1.1.1.429 from Thauera aromatica (see 2 papers)
    36% identity, 98% coverage of query (154 bits)

2ztlA Closed conformation of d-3-hydroxybutyrate dehydrogenase complexed with NAD+ and l-3-hydroxybutyrate
    33% identity, 97% coverage of query (154 bits)

Q9SCU0 xanthoxin dehydrogenase (EC 1.1.1.288) from Arabidopsis thaliana (see paper)
    37% identity, 96% coverage of query (153 bits)

AO356_20240 L-arabinose 1-dehydrogenase (EC 1.1.1.46) from Pseudomonas fluorescens FW300-N2C3
    35% identity, 98% coverage of query (152 bits)

CHCB2_SINCY / P0DXE1 Cis-4-hydroxycyclohexanecarboxylate dehydrogenase; Cis-4-hydroxyCHCA dehydrogenase; EC 1.1.1.438 from Sinomonas cyclohexanicum (Corynebacterium cyclohexanicum) (see paper)
    36% identity, 96% coverage of query (152 bits)

ptmO8 / D8L2W5 ent-kauranol 7β-dehydrogenase from Streptomyces platensis (see paper)
    33% identity, 96% coverage of query (152 bits)

5yssB / A0A0D7LY80 Crystal structure of aminocaproic acid cyclase in complex with NAD (+) (see paper)
    34% identity, 96% coverage of query (151 bits)

fabG / P51831 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Bacillus subtilis (strain 168) (see 3 papers)
    39% identity, 96% coverage of query (150 bits)

hdhA / Q9S3U5 7α-hydroxysteroid dehydrogenase subunit (EC 1.1.1.159) from Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow) (see paper)
HDHA_BACFN / Q5LA59 7alpha-hydroxysteroid dehydrogenase; 7alpha-HSDH; Aromatic aldehyde reductase; NAD-dependent 7alpha-hydroxysteroid dehydrogenase; EC 1.1.1.159; EC 1.1.1.- from Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / LMG 10263 / NCTC 9343 / Onslow / VPI 2553 / EN-2) (see 2 papers)
Q9S3U5 7alpha-hydroxysteroid dehydrogenase (EC 1.1.1.159) from Bacteroides fragilis (see paper)
    37% identity, 97% coverage of query (149 bits)

4qecA / I6ZQW6 Elxo with NADP bound (see paper)
    35% identity, 95% coverage of query (149 bits)

3BHD2_EGGLE / C8WGQ3 3beta-hydroxysteroid dehydrogenase 2; 3beta-HSDH 2; 3beta-hydroxycholanate 3-dehydrogenase (NAD(+)) 2; NAD-dependent bile acid 3beta-dehydrogenase; EC 1.1.1.-; EC 1.1.1.391 from Eggerthella lenta (strain ATCC 25559 / DSM 2243 / CCUG 17323 / JCM 9979 / KCTC 3265 / NCTC 11813 / VPI 0255 / 1899 B) (Eubacterium lentum) (see paper)
C8WGQ3 3beta-hydroxycholanate 3-dehydrogenase (NAD+) (EC 1.1.1.391) from Eggerthella lenta (see paper)
    35% identity, 97% coverage of query (148 bits)

Q8GR61 D-xylulose reductase (EC 1.1.1.9) from Gluconobacter oxydans (see 2 papers)
    35% identity, 95% coverage of query (148 bits)

1zemA / Q8GR61 Crystal structure of NAD+-bound xylitol dehydrogenase (see paper)
    35% identity, 95% coverage of query (147 bits)

CHCB1_SINCY / P0DXE0 Trans-4-hydroxycyclohexanecarboxylate dehydrogenase; Trans-4-hydroxyCHCA dehydrogenase; 4-hydroxycyclohexanecarboxylate dehydrogenase; EC 1.1.1.226 from Sinomonas cyclohexanicum (Corynebacterium cyclohexanicum) (see 2 papers)
    35% identity, 95% coverage of query (147 bits)

5h5xC / Q9KYM4 Crystal structure of nadh bound carbonyl reductase from streptomyces coelicolor
    38% identity, 95% coverage of query (146 bits)

barS1 / Q9LBV3 A-factor type γ-butyrolactone 6-reductase (6S-forming) monomer (EC 1.1.1.413) from Streptomyces virginiae (see paper)
BARS1_STRVG / Q9LBV3 A-factor type gamma-butyrolactone 1'-reductase (1S-forming); 6-dehydro-VB-A reductase; Butyrolactone autoregulator synthesis; EC 1.1.1.413 from Streptomyces virginiae (Streptomyces cinnamonensis) (see 2 papers)
    35% identity, 96% coverage of query (146 bits)

Q9HK51 aldose 1-dehydrogenase (NAD+) (EC 1.1.1.121) from Thermoplasma acidophilum (see 2 papers)
    33% identity, 97% coverage of query (145 bits)

A8R3J3 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) from Ralstonia pickettii (see paper)
    32% identity, 97% coverage of query (145 bits)

2dteA / Q9HK51 Structure of thermoplasma acidophilum aldohexose dehydrogenase (aldt) in complex with nadh (see paper)
    33% identity, 97% coverage of query (145 bits)

uxaD / Q9WYS2 fructuronate reductase from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
    34% identity, 97% coverage of query (145 bits)

1vl8B / Q9WYS2 Crystal structure of gluconate 5-dehydrogenase (tm0441) from thermotoga maritima at 2.07 a resolution
    34% identity, 97% coverage of query (145 bits)

2dtxA Structure of thermoplasma acidophilum aldohexose dehydrogenase (aldt) in complex with d-mannose
    33% identity, 97% coverage of query (145 bits)

8cxaA / A0QVD5 Crystal structure of 3-oxoacyl-[acyl-carrier-protein] reductase from mycobacterium smegmatis with bound NAD
    36% identity, 97% coverage of query (143 bits)

E5DD06 (+)-borneol dehydrogenase (EC 1.1.1.198) from Artemisia annua (see paper)
    34% identity, 97% coverage of query (143 bits)

1x1tA / Q5KST5 Crystal structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas fragi complexed with NAD+ (see paper)
    32% identity, 97% coverage of query (142 bits)

4jroC / Q8Y690 Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
    37% identity, 97% coverage of query (142 bits)

ASTE_ASPOR / Q2UEK6 Short chain dehydrogenase/reductase astE; Astellolide biosynthesis cluster protein E; EC 1.1.-.- from Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) (see paper)
    33% identity, 97% coverage of query (142 bits)

7djsD / A0A554HE32 Crystal structure of isopiperitenol dehydrogenase from pseudomonas aeruginosa complexed with NAD
    36% identity, 97% coverage of query (142 bits)

Q7XZH5 xanthoxin dehydrogenase (EC 1.1.1.288) from Oryza sativa (see paper)
    33% identity, 98% coverage of query (141 bits)

9fe6B / A0A7C5VFX3 Short-chain dehydrogenase/reductase (sdr) from thermus caliditerrae
    33% identity, 97% coverage of query (140 bits)

chnA / Q5P8S7 cyclohexanol dehydrogenase from Aromatoleum aromaticum (strain EbN1) (see paper)
4ureB / Q5P8S7 Molecular genetic and crystal structural analysis of 1-(4- hydroxyphenyl)-ethanol dehydrogenase from aromatoleum aromaticum ebn1 (see paper)
    34% identity, 96% coverage of query (140 bits)

9febA Short-chain dehydrogenase/reductase (sdr) from thermus caliditerrae in complex with NADP
    33% identity, 97% coverage of query (140 bits)

4urfB Molecular genetic and crystal structural analysis of 1-(4- hydroxyphenyl)-ethanol dehydrogenase from aromatoleum aromaticum ebn1
    34% identity, 96% coverage of query (140 bits)

4urfA Molecular genetic and crystal structural analysis of 1-(4- hydroxyphenyl)-ethanol dehydrogenase from aromatoleum aromaticum ebn1
    34% identity, 96% coverage of query (140 bits)

W5VJT8 isopiperitenol dehydrogenase (EC 1.1.1.223) from Perilla frutescens var. hirtella (see paper)
    35% identity, 96% coverage of query (139 bits)

ABA4_PYRO7 / G4N1P8 Short-chain dehydrogenase/reductase ABA4; Abscisic acid biosynthesis protein 4; EC 1.1.1.- from Pyricularia oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Magnaporthe oryzae) (see paper)
ABA4_PYRO3 / L7I518 Short-chain dehydrogenase/reductase ABA4; Abscisic acid biosynthesis protein 4; EC 1.1.1.- from Pyricularia oryzae (strain Y34) (Rice blast fungus) (Magnaporthe oryzae) (see paper)
    35% identity, 97% coverage of query (139 bits)

5itvA / P39640 Crystal structure of bacillus subtilis bacc dihydroanticapsin 7- dehydrogenase in complex with nadh (see paper)
    33% identity, 97% coverage of query (139 bits)

bacC / P39640 dihydroanticapsin dehydrogenase (EC 1.1.1.385) from Bacillus subtilis (strain 168) (see paper)
BACC_BACSU / P39640 Dihydroanticapsin 7-dehydrogenase; Bacilysin biosynthesis oxidoreductase BacC; EC 1.1.1.385 from Bacillus subtilis (strain 168) (see 3 papers)
P39640 dihydroanticapsin dehydrogenase (EC 1.1.1.385) from Bacillus subtilis (see paper)
    33% identity, 97% coverage of query (139 bits)

budC / H9XP47 meso-butanediol dehydrogenase [(R)-acetoin-forming] (EC 1.1.1.304; EC 1.1.1.76) from Serratia marcescens (see paper)
MBDH_SERMA / H9XP47 Meso-2,3-butanediol dehydrogenase; BDH; meso-2,3-BDH; (R,S)-butane-2,3-diol dehydrogenase; NAD(H)-dependent meso-2,3-BDH; SmBdh; EC 1.1.1.- from Serratia marcescens (see 3 papers)
    33% identity, 96% coverage of query (139 bits)

6vspB / H9XP47 Structure of serratia marcescens 2,3-butanediol dehydrogenase mutant q247a (see paper)
    33% identity, 96% coverage of query (139 bits)

6vspA Structure of serratia marcescens 2,3-butanediol dehydrogenase mutant q247a
    33% identity, 96% coverage of query (139 bits)

6xewA Structure of serratia marcescens 2,3-butanediol dehydrogenase
    33% identity, 96% coverage of query (139 bits)

7tzpG / A0A332H2K8 Crystal structure of putataive short-chain dehydrogenase/reductase (fabg) from klebsiella pneumoniae subsp. Pneumoniae ntuh-k2044 in complex with nadh (see paper)
    38% identity, 96% coverage of query (138 bits)

4wecA / A0QVJ7 Crystal structure of a short chain dehydrogenase from mycobacterium smegmatis
    33% identity, 98% coverage of query (138 bits)

xecD / Q56840 2-(R)-hydroxypropyl-CoM dehydrogenase subunit (EC 1.1.1.268) from Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) (see 5 papers)
HCDR1_XANP2 / Q56840 2-(R)-hydroxypropyl-CoM dehydrogenase; R-HPCDH; 2-[(R)-2-hydroxypropylthio]ethanesulfonate dehydrogenase; Aliphatic epoxide carboxylation component III; Epoxide carboxylase component III; RHPCDH1; EC 1.1.1.268 from Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) (see 7 papers)
Q56840 2-(R)-hydroxypropyl-CoM dehydrogenase (EC 1.1.1.268) from Xanthobacter autotrophicus (see 4 papers)
2cfcA / Q56840 Structural basis for stereo selectivity in the (r)- and (s)- hydroxypropylethane thiosulfonate dehydrogenases (see paper)
    33% identity, 95% coverage of query (137 bits)

4nbwA / A6G411 Crystal structure of fabg from plesiocystis pacifica (see paper)
    39% identity, 95% coverage of query (137 bits)

BWI76_RS23705 2-deoxy-D-ribonyl-CoA 3-dehydrogenase from Klebsiella michiganensis M5al
    37% identity, 97% coverage of query (137 bits)

1hdcA / P19992 Mechanism of inhibition of 3alpha,20beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor (see paper)
    37% identity, 97% coverage of query (136 bits)

2hsdA The refined three-dimensional structure of 3alpha,20beta- hydroxysteroid dehydrogenase and possible roles of the residues conserved in short-chain dehydrogenases
    37% identity, 97% coverage of query (136 bits)

PRF|1611236A 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase; EC 1.1.1.53 from Streptomyces exfoliatus (see paper)
    37% identity, 97% coverage of query (135 bits)

Q31QF3 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Synechococcus elongatus PCC 7942 = FACHB-805 (see paper)
    38% identity, 97% coverage of query (135 bits)

1gegE / Q48436 Cryatal structure analysis of meso-2,3-butanediol dehydrogenase (see paper)
    35% identity, 95% coverage of query (135 bits)

LINX_SPHIU / D4Z260 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase LinX; 2,5-DDOL dehydrogenase; EC 1.1.1.- from Sphingobium indicum (strain DSM 16413 / CCM 7287 / MTCC 6362 / UT26 / NBRC 101211 / UT26S) (Sphingobium japonicum) (see paper)
    35% identity, 97% coverage of query (134 bits)

6d9yB / B2JLJ0 Crystal structure of a short chain dehydrogenase/reductase sdr from burkholderia phymatum with partially occupied NAD
    32% identity, 98% coverage of query (134 bits)

budC / Q48436 acetoin reductase subunit (EC 1.1.1.304) from Klebsiella pneumoniae (see 4 papers)
BUDC_KLEPN / Q48436 Diacetyl reductase [(S)-acetoin forming]; Acetoin(diacetyl) reductase; AR; Meso-2,3-butanediol dehydrogenase; EC 1.1.1.304 from Klebsiella pneumoniae (see paper)
Q48436 diacetyl reductase [(S)-acetoin forming] (EC 1.1.1.304); (S,S)-butanediol dehydrogenase (EC 1.1.1.76) from Klebsiella pneumoniae (see 2 papers)
budC / GB|AAC78679.1 diacetyl reductase ((S)-acetoin forming); EC 1.1.1.304 from Klebsiella pneumoniae (see 3 papers)
    35% identity, 95% coverage of query (134 bits)

ADRF_PENRW / B6HV34 Short chain dehydrogenase adrF; Andrastin A biosynthesis cluster protein F; EC 1.1.1.- from Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)
    33% identity, 98% coverage of query (134 bits)

W5VJM4 isopiperitenol dehydrogenase (EC 1.1.1.223) from Perilla frutescens var. hirtella (see paper)
    32% identity, 96% coverage of query (133 bits)

A0A2D0WG37 cyclohexanol dehydrogenase (EC 1.1.1.245) from Acidovorax sp. (see paper)
    34% identity, 97% coverage of query (133 bits)

RUMGNA_00694 / A7AZH2 3β-hydroxysteroid dehydrogenase (EC 1.1.1.393) from Ruminococcus gnavus (strain ATCC 29149 / VPI C7-9) (see 4 papers)
3BHDP_MEDG7 / A7AZH2 3beta-hydroxysteroid dehydrogenase; 3beta-HSDH; 3beta-hydroxycholanate 3-dehydrogenase (NADP(+)); NADP-dependent bile acid 3beta-dehydrogenase; EC 1.1.1.-; EC 1.1.1.393 from Mediterraneibacter gnavus (strain ATCC 29149 / DSM 114966 / JCM 6515 / VPI C7-9) (Ruminococcus gnavus) (see paper)
A7AZH2 3beta-hydroxycholanate 3-dehydrogenase (NADP+) (EC 1.1.1.393) from [Ruminococcus] gnavus (see paper)
    34% identity, 95% coverage of query (133 bits)

SDR / F1SWA0 zerumbone synthase (EC 1.1.1.326) from Zingiber zerumbet (see paper)
ZERSY_ZINZE / F1SWA0 Zerumbone synthase; EC 1.1.1.326 from Zingiber zerumbet (Shampoo ginger) (Amomum zerumbet) (see paper)
F1SWA0 zerumbone synthase (EC 1.1.1.326) from Zingiber zerumbet (see 2 papers)
    34% identity, 97% coverage of query (133 bits)

W5VJJ6 isopiperitenol dehydrogenase (EC 1.1.1.223) from Perilla frutescens (see paper)
    32% identity, 96% coverage of query (133 bits)

2rh4B / P16544 Actinorhodin ketoreductase, actkr, with NADPH and inhibitor emodin (see paper)
    32% identity, 98% coverage of query (133 bits)

ACT3_STRCO / P16544 Putative ketoacyl reductase; EC 1.3.1.- from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see 2 papers)
    32% identity, 98% coverage of query (133 bits)

novJ / Q9L9F8 NovJ from Streptomyces niveus (see paper)
NOVJ_STRNV / Q9L9F8 Short-chain reductase protein NovJ; Novobiocin biosynthesis protein J; EC 1.1.1.- from Streptomyces niveus (Streptomyces spheroides) (see paper)
    35% identity, 96% coverage of query (132 bits)

3sj7A Structure of beta-ketoacetyl-coa reductase (fabg) from staphylococcus aureus complex with NADPH
    35% identity, 95% coverage of query (131 bits)

1w4zA Structure of actinorhodin polyketide (actiii) reductase
    32% identity, 97% coverage of query (131 bits)

4dmmB / Q31QF3 3-oxoacyl-[acyl-carrier-protein] reductase from synechococcus elongatus pcc 7942 in complex with NADP
    36% identity, 97% coverage of query (130 bits)

1xr3A Actinorhodin polyketide ketoreductase with NADP and the inhibitor isoniazid bound
    32% identity, 96% coverage of query (130 bits)

2rh4A Actinorhodin ketoreductase, actkr, with NADPH and inhibitor emodin
    32% identity, 96% coverage of query (130 bits)

DHRS6_RAT / D4A1J4 Dehydrogenase/reductase SDR family member 6; (R)-beta-hydroxybutyrate dehydrogenase; 3-hydroxybutyrate dehydrogenase type 2; 4-oxo-L-proline reductase; Oxidoreductase UCPA; Short chain dehydrogenase/reductase family 15C member 1; EC 1.1.1.-; EC 1.1.1.30; EC 1.1.1.104 from Rattus norvegicus (Rat) (see paper)
    35% identity, 97% coverage of query (130 bits)

FABG_SYNY3 / P73574 3-oxoacyl-[acyl-carrier-protein] reductase; 3-ketoacyl-acyl carrier protein reductase; EC 1.1.1.100 from Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa) (see paper)
    35% identity, 97% coverage of query (130 bits)

3ay6B / P39485 Crystal structure of bacillus megaterium glucose dehydrogenase 4 a258f mutant in complex with nadh and d-glucose (see paper)
    36% identity, 96% coverage of query (129 bits)

Build an alignment

Build an alignment for WP_157499288.1 and 100 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory