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Searching for up to 100 curated homologs for WP_245526306.1 NCBI__GCF_000186245.1:WP_245526306.1 (343 a.a.)

Found high-coverage hits (≥70%) to 46 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

7pi1DDD / P28820 7pi1DDD
    32% identity, 74% coverage of query (126 bits)

pabB / P28820 4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase) (EC 2.6.1.123) from Bacillus subtilis (strain 168) (see paper)
PABB_BACSU / P28820 Aminodeoxychorismate synthase component 1; ADC synthase; ADCS; 4-amino-4-deoxychorismate synthase component 1; EC 2.6.1.85 from Bacillus subtilis (strain 168) (see 2 papers)
P28820 4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming) (EC 2.6.1.123); aminodeoxychorismate synthase (EC 2.6.1.85) from Bacillus subtilis (see 2 papers)
pabB / GB|BAA05309.1 para-aminobenzoate synthase, component 1; EC 2.6.1.85 from Bacillus subtilis (see paper)
    32% identity, 74% coverage of query (126 bits)

B2FR92 4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming) (EC 2.6.1.123) from Stenotrophomonas maltophilia (see paper)
    31% identity, 73% coverage of query (117 bits)

Build an alignment

Build an alignment for WP_245526306.1 and 3 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

trpE / AAA25223.1 anthranilate synthase alpha subunit from Lactococcus lactis (see paper)
    29% identity, 73% coverage of query (102 bits)

ASA1_ORYSJ / Q94GF1 Anthranilate synthase alpha subunit 1, chloroplastic; OsASA1; EC 4.1.3.27 from Oryza sativa subsp. japonica (Rice) (see 2 papers)
    30% identity, 71% coverage of query (99.8 bits)

TRPE_PSEPU / P20579 Anthranilate synthase component 1; AS; ASI; EC 4.1.3.27 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
    31% identity, 71% coverage of query (99.8 bits)

AANTSYNB / Q41156 anthranilate synthase α subunit (EC 4.1.3.27) from Ruta graveolens (see paper)
    30% identity, 71% coverage of query (99.4 bits)

SGCD_STRGL / Q8GMH4 2-amino-4-deoxychorismate synthase; ADIC synthase; EC 2.6.1.86 from Streptomyces globisporus (see paper)
    29% identity, 71% coverage of query (99.4 bits)

pabAB / P32483 4-amino-4-deoxychorismate synthase (EC 2.6.1.85) from Streptomyces griseus (see 5 papers)
ADCS_STRGR / P32483 Aminodeoxychorismate synthase; ADC synthase; 4-amino-4-deoxychorismate synthase; p-aminobenzoic acid synthase; PABA synthase; EC 2.6.1.85 from Streptomyces griseus (see paper)
    32% identity, 71% coverage of query (98.6 bits)

trpE / P20580 anthranilate synthase α subunit (EC 4.1.3.27) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
TRPE_PSEAE / P20580 Anthranilate synthase component 1; AS; ASI; EC 4.1.3.27 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 3 papers)
P20580 anthranilate synthase (subunit 1/2) (EC 4.1.3.27) from Pseudomonas aeruginosa (see paper)
    30% identity, 71% coverage of query (97.8 bits)

trpE / Q08653 anthranilate synthase component I (EC 4.1.3.27) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
    31% identity, 71% coverage of query (97.4 bits)

ADCS / Q6TAS3 aminodeoxychorismate synthase (EC 2.6.1.85) from Solanum lycopersicum (see 2 papers)
ADCS_SOLLC / Q6TAS3 Aminodeoxychorismate synthase, chloroplastic; ADC synthase; P-aminobenzoic acid synthase; PABA synthase; Para-aminobenzoate synthase; EC 2.6.1.85 from Solanum lycopersicum (Tomato) (Lycopersicon esculentum) (see paper)
    31% identity, 72% coverage of query (97.4 bits)

para-aminobenzoate synthase component I / b1812 aminodeoxychorismate synthase subunit 1 (EC 2.6.1.85) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
pabB / P05041 aminodeoxychorismate synthase subunit 1 (EC 2.6.1.85) from Escherichia coli (strain K12) (see 17 papers)
PABB_ECOLI / P05041 Aminodeoxychorismate synthase component 1; ADC synthase; ADCS; 4-amino-4-deoxychorismate synthase component 1; EC 2.6.1.85 from Escherichia coli (strain K12) (see 8 papers)
pabB / RF|NP_416326.1 para-aminobenzoate synthase, component 1; EC 2.6.1.85 from Escherichia coli K12 (see 8 papers)
    28% identity, 71% coverage of query (96.7 bits)

pabB para-aminobenzoate synthase, component I from Ralstonia solanacearum (see paper)
    30% identity, 73% coverage of query (96.7 bits)

5cwaA / P9WFX2 Structure of anthranilate synthase component i (trpe) from mycobacterium tuberculosis with inhibitor bound (see paper)
    28% identity, 78% coverage of query (95.1 bits)

P9WFX2 anthranilate synthase (EC 4.1.3.27) from Mycobacterium tuberculosis (see paper)
P9WFX3 anthranilate synthase (EC 4.1.3.27) from Mycobacterium tuberculosis (see paper)
    28% identity, 78% coverage of query (95.1 bits)

1k0eA / P05041 The crystal structure of aminodeoxychorismate synthase from formate grown crystals (see paper)
    27% identity, 71% coverage of query (94.7 bits)

ASA2_ORYSJ / Q9XJ29 Anthranilate synthase alpha subunit 2, chloroplastic; OsASA2; EC 4.1.3.27 from Oryza sativa subsp. japonica (Rice) (see 3 papers)
    29% identity, 71% coverage of query (92.4 bits)

TRPE_ARATH / P32068 Anthranilate synthase alpha subunit 1, chloroplastic; Anthranilate synthase component 1-1; Anthranilate synthase component I-1; Protein A-METHYL TRYPTOPHAN RESISTANT 1; Protein JASMONATE-INDUCED DEFECTIVE LATERAL ROOT 1; Protein TRYPTOPHAN BIOSYNTHESIS 5; Protein WEAK ETHYLENE INSENSITIVE 2; EC 4.1.3.27 from Arabidopsis thaliana (Mouse-ear cress) (see 7 papers)
    28% identity, 71% coverage of query (92.4 bits)

ADCS_SCHPO / O94277 Putative aminodeoxychorismate synthase; ADC synthase; P-aminobenzoic acid synthase; PABA synthase; Para-aminobenzoate synthase; EC 2.6.1.85 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    28% identity, 75% coverage of query (91.3 bits)

trpE / Q06128 anthranilate synthase α subunit (EC 4.1.3.27) from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (see paper)
TRPE_SACS2 / Q06128 Anthranilate synthase component 1; AS; ASI; EC 4.1.3.27 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
Q06128 anthranilate synthase (subunit 2/2) (EC 4.1.3.27) from Saccharolobus solfataricus (see paper)
    29% identity, 74% coverage of query (89.7 bits)

ADCS_YEAST / P37254 Aminodeoxychorismate synthase; ADC synthase; P-aminobenzoic acid synthase; PABA synthase; Para-aminobenzoate synthase; EC 2.6.1.85 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
    29% identity, 71% coverage of query (89.4 bits)

cmlB / F2RB79 4-amino-4-deoxychorismate synthase (EC 2.6.1.85) from Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745) (see 2 papers)
ADCS_STRVP / F2RB79 Aminodeoxychorismate synthase; ADC synthase; 4-amino-4-deoxychorismate synthase; p-aminobenzoate synthase; EC 2.6.1.85 from Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745) (see paper)
    32% identity, 71% coverage of query (89.0 bits)

papA / BAD21140.1 4-amino-4-deoxychorismate synthase from Streptomyces venezuelae (see paper)
    32% identity, 71% coverage of query (89.0 bits)

trpE anthranilate synthase component I; EC 4.1.3.27 from Leptospira biflexa serovar Patoc (see paper)
    30% identity, 71% coverage of query (88.6 bits)

8hx8A / F2RB79 Crystal structure of 4-amino-4-deoxychorismate synthase from streptomyces venezuelae co-crystallized with chorismate (see paper)
    32% identity, 71% coverage of query (88.6 bits)

8hx9A / F2RB79 Crystal structure of 4-amino-4-deoxychorismate synthase from streptomyces venezuelae with chorismate (see paper)
    32% identity, 71% coverage of query (88.2 bits)

pabaA para-aminobenzoic acid synthase from Emericella nidulans (see 2 papers)
    28% identity, 71% coverage of query (87.8 bits)

phnA / P09785 PhnA anthranilate synthase subunit (EC 4.1.3.27) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 3 papers)
PHNA_PSEAE / P09785 Anthranilate synthase component 1, pyocyanine specific; AS; ASI; Anthranilate synthase alpha subunit, pyocyanine specific; EC 4.1.3.27 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 3 papers)
P09785 anthranilate synthase (subunit 2/2) (EC 4.1.3.27) from Pseudomonas aeruginosa (see paper)
    27% identity, 71% coverage of query (87.8 bits)

Q9AW95 anthranilate synthase (EC 4.1.3.27) from Catharanthus roseus (see paper)
    28% identity, 71% coverage of query (84.7 bits)

1k0gA The crystal structure of aminodeoxychorismate synthase from phosphate grown crystals
    26% identity, 71% coverage of query (84.0 bits)

Q5XLF2 anthranilate synthase (EC 4.1.3.27) from Camptotheca acuminata (see paper)
    29% identity, 71% coverage of query (83.2 bits)

1k0gB / P05041 The crystal structure of aminodeoxychorismate synthase from phosphate grown crystals (see paper)
    25% identity, 71% coverage of query (82.0 bits)

Q5XLF3 anthranilate synthase (EC 4.1.3.27) from Camptotheca acuminata (see paper)
    28% identity, 71% coverage of query (80.5 bits)

pabaA / GI|4885032 para aminobenzoic acid synthetase from Aspergillus fumigatus (see paper)
    29% identity, 71% coverage of query (79.0 bits)

1i1qA / P00898 Structure of the cooperative allosteric anthranilate synthase from salmonella typhimurium (see paper)
    26% identity, 71% coverage of query (77.8 bits)

TRPE_SALTY / P00898 Anthranilate synthase component 1; AS; ASI; EC 4.1.3.27 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
    26% identity, 71% coverage of query (77.4 bits)

ADCS_STRPR / P72539 Aminodeoxychorismate synthase; ADC synthase; 4-amino-4-deoxychorismate synthase; EC 2.6.1.85 from Streptomyces pristinaespiralis (see paper)
    27% identity, 90% coverage of query (77.4 bits)

8w6vA / Q9S7H8 Structural basis of chorismate isomerization by arabidopsis isochorismate synthase ics1 (see paper)
    29% identity, 70% coverage of query (73.9 bits)

8w71A Structural basis of chorismate isomerization by arabidopsis isochorismate synthase ics1
    29% identity, 70% coverage of query (73.9 bits)

5jy9B / A1JTF3 An iron-bound structure of the salicylate synthase irp9 (see paper)
    26% identity, 81% coverage of query (70.5 bits)

2fn1A Crystal structures of yersinia enterocolitica salicylate synthase (irp9) in complex with the reaction products salicylate and pyruvate
    25% identity, 79% coverage of query (66.2 bits)

2fn0A Crystal structure of yersinia enterocolitica salicylate synthase (irp9)
    25% identity, 79% coverage of query (66.2 bits)

1i7sA Anthranilate synthase from serratia marcescens in complex with its end product inhibitor l-tryptophan
    26% identity, 71% coverage of query (65.5 bits)

P45744 Isochorismate synthase DhbC; Isochorismate mutase; EC 5.4.4.2 from Bacillus subtilis (strain 168)
    24% identity, 73% coverage of query (56.2 bits)

3r75B / Q396C7 Crystal structure of 2-amino-2-desoxyisochorismate synthase (adic) synthase phze from burkholderia lata 383 in complex with benzoate, pyruvate, glutamine and contaminating zn2+ (see paper)
    27% identity, 77% coverage of query (51.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory