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Searching for up to 100 curated homologs for YP_004143517.1 NCBI__GCF_000185905.1:YP_004143517.1 (221 a.a.)

Found high-coverage hits (≥70%) to 70 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Pf6N2E2_5292 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas fluorescens FW300-N2E2
    31% identity, 90% coverage of query (79.0 bits)

AO353_15560 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas fluorescens FW300-N2E3
    30% identity, 83% coverage of query (77.4 bits)

AO356_16835 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas fluorescens FW300-N2C3
    30% identity, 90% coverage of query (73.9 bits)

MAAI2_DROME / Q9VHD2 Probable maleylacetoacetate isomerase 2; MAAI 2; Glutathione S-transferase zeta 2; EC 5.2.1.2; EC 2.5.1.18 from Drosophila melanogaster (Fruit fly) (see paper)
    33% identity, 76% coverage of query (73.6 bits)

MAAI1_DROME / Q9VHD3 Probable maleylacetoacetate isomerase 1; MAAI 1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Drosophila melanogaster (Fruit fly) (see paper)
    32% identity, 72% coverage of query (72.0 bits)

2v6kA / O86043 Structure of maleyl pyruvate isomerase, a bacterial glutathione-s- transferase in zeta class, in complex with substrate analogue dicarboxyethyl glutathione (see paper)
    32% identity, 73% coverage of query (70.5 bits)

nagL / O86043 glutathion-dependent maleylpyruvate isomerase (EC 5.2.1.4) from Ralstonia sp. (see paper)
NAGL_RALSP / O86043 Maleylpyruvate isomerase; MPI; Naphthalene degradation protein L; EC 5.2.1.4 from Ralstonia sp. (see 2 papers)
    32% identity, 73% coverage of query (70.1 bits)

2jl4A Holo structure of maleyl pyruvate isomerase, a bacterial glutathione- s-transferase in zeta class
    32% identity, 73% coverage of query (70.1 bits)

Pog / b3229 stringent starvation protein A from Escherichia coli K-12 substr. MG1655 (see 8 papers)
TC 1.A.12.3.1 / P0ACA3 The bacterial CLIC homologue, stringent starvation protein A, SspA (212 aas; 0 TMSs) [N-terminal Trx domain; C-terminal glutathione S-transferase (GST) domain] from Escherichia coli (strain K12) (see 5 papers)
sspA stringent starvation protein A from Escherichia coli K12 (see 5 papers)
    30% identity, 73% coverage of query (63.5 bits)

Q8RW04 glutathione transferase (EC 2.5.1.18) from Triticum aestivum (see paper)
    30% identity, 72% coverage of query (63.5 bits)

Psest_3511 Maleylacetoacetate isomerase (EC 5.2.1.2) from Pseudomonas stutzeri RCH2
    32% identity, 77% coverage of query (63.5 bits)

Build an alignment

Build an alignment for YP_004143517.1 and 11 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

SO1671 Maleylacetoacetate isomerase (EC 5.2.1.2) from Shewanella oneidensis MR-1
    26% identity, 76% coverage of query (62.4 bits)

Q8RW02 glutathione transferase (EC 2.5.1.18) from Triticum aestivum (see paper)
    29% identity, 72% coverage of query (61.2 bits)

4gltA / Q1GZF4 Crystal structure of glutathione s-transferase mfla_2116 (target efi- 507160) from methylobacillus flagellatus kt with gsh bound
    27% identity, 71% coverage of query (61.2 bits)

gst7 / CAB38121.1 GST7 protein from Zea mays (see paper)
    31% identity, 71% coverage of query (60.8 bits)

GSTZ1_ARATH / Q9ZVQ3 Glutathione S-transferase Z1; AtGSTZ1; GST class-zeta member 1; Glutathione S-transferase 18; Maleylacetone isomerase; MAI; EC 2.5.1.18; EC 5.2.1.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    29% identity, 73% coverage of query (58.9 bits)

3touA / Q8XVV6 Crystal structure of glutathione transferase (target efi-501058) from ralstonia solanacearum gmi1000 with gsh bound
    25% identity, 71% coverage of query (58.9 bits)

Q5K5T6 glutathione transferase subunit (EC 2.5.1.18) from Escherichia coli (see 8 papers)
    26% identity, 89% coverage of query (58.5 bits)

4qq7A / B4E6Q3 Crystal structure of putative stringent starvation protein a from burkholderia cenocepacia with bound glutathione
    29% identity, 73% coverage of query (57.8 bits)

4hojA / O33374 Crystal structure of glutathione transferase homolog from neisseria gonorrhoeae, target efi-501841, with bound glutathione
    26% identity, 79% coverage of query (57.0 bits)

3vlnA Human glutathione transferase o1-1 c32s mutant in complex with ascorbic acid
    26% identity, 90% coverage of query (56.6 bits)

Ac3H11_2306 Maleylacetoacetate isomerase (EC 5.2.1.2) from Acidovorax sp. GW101-3H11
    31% identity, 77% coverage of query (55.8 bits)

4mk3A / Q1LJ46 Crystal structure of a glutathione transferase family member from cupriavidus metallidurans ch34, target efi-507362, with bound glutathione sulfinic acid (gso2h)
    26% identity, 71% coverage of query (55.5 bits)

GSTO1 / P78417 glutathione transferase, Ω class subunit (EC 2.5.1.18; EC 1.8.5.1; EC 1.20.4.2) from Homo sapiens (see 2 papers)
GSTO1_HUMAN / P78417 Glutathione S-transferase omega-1; GSTO-1; Glutathione S-transferase omega 1-1; GSTO 1-1; Glutathione-dependent dehydroascorbate reductase; Monomethylarsonic acid reductase; MMA(V) reductase; S-(Phenacyl)glutathione reductase; SPG-R; EC 2.5.1.18; EC 1.8.5.1; EC 1.20.4.2 from Homo sapiens (Human) (see 5 papers)
P78417 methylarsonate reductase (EC 1.20.4.2); glutathione dehydrogenase (ascorbate) (EC 1.8.5.1); glutathione transferase (EC 2.5.1.18) from Homo sapiens (see 7 papers)
    25% identity, 90% coverage of query (55.1 bits)

6mhcA / P78417 Glutathione s-transferase omega 1 bound to covalent inhibitor 37 (see paper)
    25% identity, 90% coverage of query (55.1 bits)

4yqvA Glutathione s-transferase omega 1 bound to covalent inhibitor c4-10
    25% identity, 90% coverage of query (55.1 bits)

4yqmA Glutathione s-transferase omega 1 bound to covalent inhibitor c1-27
    25% identity, 90% coverage of query (55.1 bits)

1eemA Glutathione transferase from homo sapiens
    25% identity, 90% coverage of query (55.1 bits)

6pnoA Human gsto1-1 complexed with 2-chloro-n-(4-chloro-3-(n- isopropylsulfamoyl)phenyl)acetamide
    25% identity, 90% coverage of query (55.1 bits)

6pnmA Human gsto1-1 complexed with 2-chloro-n-(4-chloro-3- (morpholinosulfonyl)phenyl)acetamide
    25% identity, 90% coverage of query (55.1 bits)

5v3qA Human gsto1-1 complexed with ml175
    25% identity, 90% coverage of query (55.1 bits)

5uehA Structure of gsto1 covalently conjugated to quinolinic acid fluorosulfate
    25% identity, 90% coverage of query (55.1 bits)

4is0A Structural insights into omega-class glutathione transferases: a snapshot of enzyme reduction and identification of the non-catalytic ligandin site.
    25% identity, 90% coverage of query (55.1 bits)

6pnnA Human gsto1-1 complexed with 2-chloro-n-(4-chloro-3-(n-(2- methoxyethyl)-n-methylsulfamoyl)phenyl)acetamide
    25% identity, 90% coverage of query (55.1 bits)

6mhdA Glutathione s-transferase omega 1 bound to covalent inhibitor 44
    25% identity, 90% coverage of query (55.1 bits)

A0A4Y5R032 glutathione transferase (EC 2.5.1.18) from Salix babylonica (see paper)
    32% identity, 71% coverage of query (54.3 bits)

5j4uA / B9I0G5 Crystal structure of a glutathione s-transferase ptgstu30 from populus trichocarpa in complex with gsh
    26% identity, 71% coverage of query (53.5 bits)

SSPA_COXBU / Q83AY0 Stringent starvation protein A homolog from Coxiella burnetii (strain RSA 493 / Nine Mile phase I) (see paper)
    30% identity, 73% coverage of query (53.5 bits)

A0A4Y5R0L5 glutathione transferase (EC 2.5.1.18) from Salix babylonica (see paper)
    25% identity, 79% coverage of query (53.1 bits)

6srbB / A0A1M2V359 Crystal structure of glutathione transferase omega 3c from trametes versicolor (see paper)
    27% identity, 72% coverage of query (52.4 bits)

Q8GTB9 glutathione transferase (EC 2.5.1.18) from Triticum aestivum (see paper)
    27% identity, 91% coverage of query (52.4 bits)

4yquA Glutathione s-transferase omega 1 bound to covalent inhibitor c1-31
    24% identity, 90% coverage of query (52.4 bits)

6mhbA Glutathione s-transferase omega 1 bound to covalent inhibitor 18
    24% identity, 90% coverage of query (52.4 bits)

7dw4A / A0A4Y5R032 Crystal structure of a glutathione s-transferase mutant sbgstu6(i55t) from salix babylonica in complex with glutathione
    32% identity, 71% coverage of query (52.0 bits)

4g10A / Q9WXJ9 Ligg from sphingobium sp. Syk-6 is related to the glutathione transferase omega class (see paper)
    28% identity, 73% coverage of query (52.0 bits)

A0A4Y5R0K8 glutathione transferase (EC 2.5.1.18) from Salix babylonica (see paper)
    28% identity, 71% coverage of query (52.0 bits)

ligG / Q9WXJ9 glutathione lyase from Sphingomonas paucimobilis (see 3 papers)
    28% identity, 73% coverage of query (52.0 bits)

4yavA Crystal structure of ligg in complex with b-glutathionyl- acetoveratrone (gs-av) from sphingobium sp. Strain syk-6
    28% identity, 73% coverage of query (52.0 bits)

3qagA / Q9H4Y5 Human glutathione transferase o2 with glutathione -new crystal form (see paper)
    27% identity, 91% coverage of query (51.6 bits)

Q8LGN6 glutathione transferase (EC 2.5.1.18) from Triticum aestivum (see paper)
    28% identity, 79% coverage of query (51.6 bits)

8jzkA Crystal structure of glutathione s-transferase tau7 from salix lindleyana in complex with gsh
    24% identity, 79% coverage of query (51.6 bits)

GSTO2_HUMAN / Q9H4Y5 Glutathione S-transferase omega-2; GSTO-2; Glutathione S-transferase omega 2-2; GSTO 2-2; Glutathione-dependent dehydroascorbate reductase; Monomethylarsonic acid reductase; MMA(V) reductase; EC 2.5.1.18; EC 1.8.5.1; EC 1.20.4.2 from Homo sapiens (Human) (see 3 papers)
Q9H4Y5 glutathione dehydrogenase (ascorbate) (EC 1.8.5.1); glutathione transferase (EC 2.5.1.18) from Homo sapiens (see 3 papers)
    27% identity, 91% coverage of query (51.6 bits)

GSTO1_PIG / Q9N1F5 Glutathione S-transferase omega-1; GSTO-1; Glutathione S-transferase omega 1-1; GSTO 1-1; Glutathione-dependent dehydroascorbate reductase; Monomethylarsonic acid reductase; MMA(V) reductase; S-(Phenacyl)glutathione reductase; SPG-R; EC 2.5.1.18; EC 1.8.5.1; EC 1.20.4.2 from Sus scrofa (Pig) (see paper)
    25% identity, 73% coverage of query (50.8 bits)

GSTE_PSEP1 / P82998 Glutathione S-transferase; EC 2.5.1.18 from Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) (see paper)
    23% identity, 99% coverage of query (50.8 bits)

L7QHV5 glutathione transferase (EC 2.5.1.18) from Oncorhynchus kisutch (see paper)
    23% identity, 88% coverage of query (50.4 bits)

A0A4Y5QZX0 glutathione transferase (EC 2.5.1.18) from Salix babylonica (see paper)
    25% identity, 91% coverage of query (50.1 bits)

4chsA Crystal structure of a tau class glutathione transferase 10 from glycine max
    25% identity, 73% coverage of query (50.1 bits)

D2WL57 glutathione transferase (EC 2.5.1.18) from Populus trichocarpa (see paper)
    26% identity, 71% coverage of query (49.7 bits)

3uarA / Q60CN1 Crystal structure of glutathione transferase (target efi-501774) from methylococcus capsulatus str. Bath with gsh bound
    27% identity, 72% coverage of query (49.7 bits)

1f2eA / O33705 Structure of sphingomonad, glutathione s-transferase complexed with glutathione
GST / AAC46031.1 glutathione S-transferase from Sphingomonas paucimobilis (see paper)
    27% identity, 73% coverage of query (49.7 bits)

6m1tA / O30347 Bacterial beta class sphingomonas chungbukensis glutathione s- transferase
    27% identity, 73% coverage of query (48.5 bits)

3ublA / Q8F2Y8 Crystal structure of glutathione transferase (target efi-501770) from leptospira interrogans with gsh bound
    28% identity, 71% coverage of query (48.1 bits)

3pr8A / Q88RE7 Structure of glutathione s-transferase(pp0183) from pseudomonas putida in complex with gsh
    24% identity, 99% coverage of query (47.8 bits)

GTT2 / Q12390 glutathione transferase 2 monomer (EC 2.5.1.18) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 13 papers)
GST2_YEAST / Q12390 Glutathione S-transferase 2; GST-II; EC 2.5.1.18 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    26% identity, 71% coverage of query (45.8 bits)

3ibhA Crystal structure of saccharomyces cerevisiae gtt2 in complex with glutathione
    26% identity, 71% coverage of query (45.8 bits)

3ergA / Q12390 Crystal structure of gtt2 from saccharomyces cerevisiae in complex with glutathione sulfnate (see paper)
    26% identity, 71% coverage of query (45.8 bits)

2dsaA Ternary complex of bphk, a bacterial gst
    22% identity, 86% coverage of query (43.1 bits)

2gdrA / Q59721 Crystal structure of a bacterial glutathione transferase (see paper)
    22% identity, 86% coverage of query (42.7 bits)

4agsA / A4I8P2 Leishmania tdr1 - a unique trimeric glutathione transferase (see paper)
    23% identity, 90% coverage of query (42.7 bits)

1v2aB / Q9BHB0 Glutathione s-transferase 1-6 from anopheles dirus species b (see paper)
    26% identity, 74% coverage of query (42.4 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory