# Candidate

orgId: NCBI__GCA_002787815.1
pathwayId: cys
stepId: serA
locusId: PIQ63453.1
sysName: COV99_02910
desc: phosphoglycerate dehydrogenase
curatedIds:
BRENDA::C3SVM7,BRENDA::P0A9T0,CharProtDB::CH_088336,SwissProt::P0A9T0,ecocyc::PGLYCDEHYDROG-MONOMER,metacyc::PGLYCDEHYDROG-MONOMER


orgId: NCBI__GCA_002787815.1
pathwayId: his
stepId: hisA
locusId: PIQ63788.1
sysName: COV99_00910
desc: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
curatedIds: reanno::azobra:AZOBR_RS01680
hmmId: TIGR00007
hmmDesc:
hisA: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase (EC 5.3.1.16)


orgId: NCBI__GCA_002787815.1
pathwayId: his
stepId: hisH
locusId: PIQ63271.1
sysName: COV99_03550
desc: imidazole glycerol phosphate synthase subunit HisH
curatedIds:
CharProtDB::CH_024511,SwissProt::P60595,ecocyc::GLUTAMIDOTRANS-MONOMER,metacyc::GLUTAMIDOTRANS-MONOMER


orgId: NCBI__GCA_002787815.1
pathwayId: ile
stepId: ilvH
locusId: PIQ60911.1
sysName: COV99_10545
desc: acetolactate synthase small subunit
hmmId: TIGR00119
hmmDesc: ilvN: acetolactate synthase, small subunit (EC 2.2.1.6)
curatedIds:
BRENDA::P00894,CharProtDB::CH_002163,ecocyc::ACETOLACTSYNIII-HCHAIN-MONOMER,metacyc::ACETOLACTSYNIII-HCHAIN-MONOMER


orgId: NCBI__GCA_002787815.1
pathwayId: met
stepId: metH
locusId: PIQ60079.1
sysName: COV99_12235
desc: methionine synthase
hmmId: TIGR02082
hmmDesc: metH: methionine synthase (EC 2.1.1.13)
curatedIds:
CharProtDB::CH_090726,SwissProt::P13009,ecocyc::HOMOCYSMETB12-MONOMER,metacyc::HOMOCYSMETB12-MONOMER


orgId: NCBI__GCA_002787815.1
pathwayId: phe
stepId: PPYAT
locusId: PIQ60531.1
sysName: COV99_11420
desc: branched chain amino acid aminotransferase
curatedIds:
CharProtDB::CH_024500,ecocyc::BRANCHED-CHAINAMINOTRANSFER-MONOMER,metacyc::BRANCHED-CHAINAMINOTRANSFER-MONOMER


# RequirementNotMet

orgId: NCBI__GCA_002787815.1
pathwayId: cys
ruleId: from-serine-homocysteine
requiredPathwayId: met
requiredRuleId: homocysteine
comment:
Cysteine biosynthesis via the reverse transsulfuration pathway requires homocysteine, which is an intermediate in methionine biosynthesis. Homocysteine is also an intermediate in the S-adenosylmethionine cycle, so many organisms that cannot synthesize methionine can convert it to homocysteine.


