# Candidate

orgId: NCBI__GCA_002790095.1
pathwayId: his
stepId: hisA
locusId: PJB26841.1
sysName: CO113_01510
desc: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
curatedIds: ecocyc::PRIBFAICARPISOM-MONOMER,metacyc::PRIBFAICARPISOM-MONOMER
hmmId: TIGR00007
hmmDesc:
hisA: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase (EC 5.3.1.16)


orgId: NCBI__GCA_002790095.1
pathwayId: his
stepId: hisG
locusId: PJB26837.1
sysName: CO113_01485
desc: ATP phosphoribosyltransferase
hmmId: TIGR00070
hmmDesc: hisG: ATP phosphoribosyltransferase (EC 2.4.2.17)
curatedIds:
CharProtDB::CH_024688,SwissProt::P60757,ecocyc::ATPPHOSRIBOSTRANS-MONOMER,metacyc::ATPPHOSRIBOSTRANS-MONOMER


orgId: NCBI__GCA_002790095.1
pathwayId: his
stepId: hisH
locusId: PJB26840.1
sysName: CO113_01505
desc: imidazole glycerol phosphate synthase subunit HisH
hmmId: TIGR01855
hmmDesc: hisH: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit (EC 2.4.2.-)
curatedIds:
CharProtDB::CH_024511,SwissProt::P60595,ecocyc::GLUTAMIDOTRANS-MONOMER,metacyc::GLUTAMIDOTRANS-MONOMER


orgId: NCBI__GCA_002790095.1
pathwayId: phe
stepId: PPYAT
locusId: PJB27055.1
sysName: CO113_00315
desc: branched-chain-amino-acid transaminase
curatedIds:
CharProtDB::CH_024500,ecocyc::BRANCHED-CHAINAMINOTRANSFER-MONOMER,metacyc::BRANCHED-CHAINAMINOTRANSFER-MONOMER


orgId: NCBI__GCA_002790095.1
pathwayId: phe
stepId: cmutase
locusId: PJB23483.1
sysName: CO113_17875
desc: prephenate dehydratase
hmmId: PF01817
hmmDesc: CM_2
curatedIds:
CharProtDB::CH_024084,SwissProt::P0A9J8,ecocyc::CHORISMUTPREPHENDEHYDRAT-MONOMER,metacyc::CHORISMUTPREPHENDEHYDRAT-MONOMER


orgId: NCBI__GCA_002790095.1
pathwayId: trp
stepId: trpD_1
locusId: PJB23206.1
sysName: CO113_19220
desc: glutamine-hydrolyzing GMP synthase
curatedIds: uniprot:Q72EV2_DESVH
otherIds:
BRENDA::P04079,CharProtDB::CH_003303,SwissProt::P04079,ecocyc::GMP-SYN-MONOMER,metacyc::GMP-SYN-MONOMER


# RequirementNotMet

orgId: NCBI__GCA_002790095.1
pathwayId: cys
ruleId: from-serine-homocysteine
requiredPathwayId: met
requiredRuleId: homocysteine
comment:
Cysteine biosynthesis via the reverse transsulfuration pathway requires homocysteine, which is an intermediate in methionine biosynthesis. Homocysteine is also an intermediate in the S-adenosylmethionine cycle, so many organisms that cannot synthesize methionine can convert it to homocysteine.


