# Candidate

orgId: NCBI__GCA_003443635.1
pathwayId: his
stepId: hisA
locusId: AXT21252.1
sysName: D1817_08915
desc: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
curatedIds: reanno::Btheta:350907
hmmId: TIGR00007
hmmDesc:
hisA: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase (EC 5.3.1.16)


orgId: NCBI__GCA_003443635.1
pathwayId: his
stepId: hisH
locusId: AXT19999.1
sysName: D1817_08905
desc: imidazole glycerol phosphate synthase subunit HisH
hmmId: TIGR01855
hmmDesc: hisH: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit (EC 2.4.2.-)
curatedIds:
CharProtDB::CH_024511,SwissProt::P60595,ecocyc::GLUTAMIDOTRANS-MONOMER,metacyc::GLUTAMIDOTRANS-MONOMER


orgId: NCBI__GCA_003443635.1
pathwayId: met
stepId: metH
locusId: AXT19032.1
sysName: D1817_03865
desc: methionine synthase
locusId2: AXT19031.1
sysName2: D1817_03860
desc2: 5-methyltetrahydrofolate--homocysteine methyltransferase
hmmId: TIGR02082
hmmDesc: metH: methionine synthase (EC 2.1.1.13)
curatedIds:
CharProtDB::CH_090726,SwissProt::P13009,ecocyc::HOMOCYSMETB12-MONOMER,metacyc::HOMOCYSMETB12-MONOMER


orgId: NCBI__GCA_003443635.1
pathwayId: thr
stepId: thrC
locusId: AXT21074.1
sysName: D1817_14715
desc: threonine synthase
hmmId: TIGR00260
hmmDesc: thrC: threonine synthase (EC 4.2.3.1)
otherIds: SwissProt::Q80W22
curatedIds:
BRENDA::P00934,CharProtDB::CH_002114,SwissProt::P00934,ecocyc::THRESYN-MONOMER,metacyc::THRESYN-MONOMER


# RequirementNotMet

orgId: NCBI__GCA_003443635.1
pathwayId: cys
ruleId: from-serine-homocysteine
requiredPathwayId: met
requiredRuleId: homocysteine
comment:
Cysteine biosynthesis via the reverse transsulfuration pathway requires homocysteine, which is an intermediate in methionine biosynthesis. Homocysteine is also an intermediate in the S-adenosylmethionine cycle, so many organisms that cannot synthesize methionine can convert it to homocysteine.


