# Candidate

orgId: NCBI__GCA_016700415.1
pathwayId: met
stepId: metH
locusId: QQS71329.1
sysName: IPP95_08975
desc: methionine synthase
locusId2: QQS71330.1
sysName2: IPP95_08980
desc2: homocysteine S-methyltransferase family protein
hmmId: TIGR02082
hmmDesc: metH: methionine synthase (EC 2.1.1.13)
otherIds: SwissProt::O06745
curatedIds:
CharProtDB::CH_090726,SwissProt::P13009,ecocyc::HOMOCYSMETB12-MONOMER,metacyc::HOMOCYSMETB12-MONOMER


orgId: NCBI__GCA_016700415.1
pathwayId: trp
stepId: trpD_1
locusId: QQS73120.1
sysName: IPP95_02510
desc: glutamine-hydrolyzing GMP synthase
curatedIds: uniprot:B8DM46_DESVM
otherIds:
BRENDA::P04079,CharProtDB::CH_003303,SwissProt::P04079,ecocyc::GMP-SYN-MONOMER,metacyc::GMP-SYN-MONOMER


# RequirementNotMet

orgId: NCBI__GCA_016700415.1
pathwayId: cys
ruleId: from-serine-homocysteine
requiredPathwayId: met
requiredRuleId: homocysteine
comment:
Cysteine biosynthesis via the reverse transsulfuration pathway requires homocysteine, which is an intermediate in methionine biosynthesis. Homocysteine is also an intermediate in the S-adenosylmethionine cycle, so many organisms that cannot synthesize methionine can convert it to homocysteine.


