# Candidate

orgId: NCBI__GCA_019695235.1
pathwayId: his
stepId: hisA
locusId: MBX7202615.1
sysName: K1X77_06060
desc: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
curatedIds: reanno::Cola:Echvi_2515
hmmId: TIGR00007
hmmDesc:
hisA: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase (EC 5.3.1.16)


orgId: NCBI__GCA_019695235.1
pathwayId: his
stepId: hisH
locusId: MBX7202616.1
sysName: K1X77_06065
desc: imidazole glycerol phosphate synthase subunit HisH
hmmId: TIGR01855
hmmDesc: hisH: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit (EC 2.4.2.-)
curatedIds:
CharProtDB::CH_024511,SwissProt::P60595,ecocyc::GLUTAMIDOTRANS-MONOMER,metacyc::GLUTAMIDOTRANS-MONOMER


orgId: NCBI__GCA_019695235.1
pathwayId: met
stepId: metH
locusId: MBX7202305.1
sysName: K1X77_04470
desc: methionine synthase
hmmId: TIGR02082
hmmDesc: metH: methionine synthase (EC 2.1.1.13)
curatedIds:
CharProtDB::CH_090726,SwissProt::P13009,ecocyc::HOMOCYSMETB12-MONOMER,metacyc::HOMOCYSMETB12-MONOMER


orgId: NCBI__GCA_019695235.1
pathwayId: phe
stepId: PPYAT
locusId: MBX7202040.1
sysName: K1X77_03135
desc: branched-chain amino acid aminotransferase
curatedIds:
CharProtDB::CH_024500,ecocyc::BRANCHED-CHAINAMINOTRANSFER-MONOMER,metacyc::BRANCHED-CHAINAMINOTRANSFER-MONOMER


orgId: NCBI__GCA_019695235.1
pathwayId: phe
stepId: cmutase
locusId: MBX7203408.1
sysName: K1X77_10075
desc: prephenate dehydratase
otherIds: reanno::Cola:Echvi_0123
curatedIds:
CharProtDB::CH_024084,SwissProt::P0A9J8,ecocyc::CHORISMUTPREPHENDEHYDRAT-MONOMER,metacyc::CHORISMUTPREPHENDEHYDRAT-MONOMER


orgId: NCBI__GCA_019695235.1
pathwayId: trp
stepId: trpE
locusId: MBX7203246.1
sysName: K1X77_09255
desc: anthranilate synthase component I family protein
curatedIds: curated2:Q5V213
otherIds:
CharProtDB::CH_002963,SwissProt::P05041,ecocyc::PABASYN-COMPI-MONOMER,metacyc::PABASYN-COMPI-MONOMER


# RequirementNotMet

orgId: NCBI__GCA_019695235.1
pathwayId: cys
ruleId: from-serine-homocysteine
requiredPathwayId: met
requiredRuleId: homocysteine
comment:
Cysteine biosynthesis via the reverse transsulfuration pathway requires homocysteine, which is an intermediate in methionine biosynthesis. Homocysteine is also an intermediate in the S-adenosylmethionine cycle, so many organisms that cannot synthesize methionine can convert it to homocysteine.


