# Candidate

orgId: NCBI__GCA_020632715.1
pathwayId: chorismate
stepId: aroE
locusId: MCB9736750.1
sysName: H6745_29575
desc: glutamyl-tRNA reductase
curatedIds: curated2:A0B999
otherIds:
BRENDA::P0A6X1,CharProtDB::CH_024665,SwissProt::P0A6X1,ecocyc::GLUTRNAREDUCT-MONOMER,metacyc::GLUTRNAREDUCT-MONOMER


orgId: NCBI__GCA_020632715.1
pathwayId: met
stepId: metH
locusId: MCB9733516.1
sysName: H6745_13015
desc: methionine synthase
hmmId: TIGR02082
hmmDesc: metH: methionine synthase (EC 2.1.1.13)
curatedIds:
CharProtDB::CH_090726,SwissProt::P13009,ecocyc::HOMOCYSMETB12-MONOMER,metacyc::HOMOCYSMETB12-MONOMER


orgId: NCBI__GCA_020632715.1
pathwayId: trp
stepId: trpD_1
locusId: MCB9733646.1
sysName: H6745_13685
desc: glutamine-hydrolyzing GMP synthase
curatedIds: SwissProt::P26922
otherIds:
BRENDA::P04079,CharProtDB::CH_003303,SwissProt::P04079,ecocyc::GMP-SYN-MONOMER,metacyc::GMP-SYN-MONOMER


# RequirementNotMet

orgId: NCBI__GCA_020632715.1
pathwayId: cys
ruleId: from-serine-homocysteine
requiredPathwayId: met
requiredRuleId: homocysteine
comment:
Cysteine biosynthesis via the reverse transsulfuration pathway requires homocysteine, which is an intermediate in methionine biosynthesis. Homocysteine is also an intermediate in the S-adenosylmethionine cycle, so many organisms that cannot synthesize methionine can convert it to homocysteine.


