# Candidate

orgId: NCBI__GCA_025059945.1
pathwayId: his
stepId: hisA
locusId: MCS7155490.1
sysName: NZ993_06765
desc: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
curatedIds: reanno::Putida:PP_0292
hmmId: TIGR00007
hmmDesc:
hisA: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase (EC 5.3.1.16)


orgId: NCBI__GCA_025059945.1
pathwayId: phe
stepId: PPYAT
locusId: MCS7154243.1
sysName: NZ993_00320
desc: branched-chain amino acid transaminase
curatedIds:
CharProtDB::CH_024500,ecocyc::BRANCHED-CHAINAMINOTRANSFER-MONOMER,metacyc::BRANCHED-CHAINAMINOTRANSFER-MONOMER


orgId: NCBI__GCA_025059945.1
pathwayId: trp
stepId: trpD_1
locusId: MCS7154843.1
sysName: NZ993_03430
desc: glutamine-hydrolyzing GMP synthase
curatedIds: BRENDA::P20576,SwissProt::P20576,metacyc::MONOMER-16006
otherIds:
BRENDA::P04079,CharProtDB::CH_003303,SwissProt::P04079,ecocyc::GMP-SYN-MONOMER,metacyc::GMP-SYN-MONOMER


# RequirementNotMet

orgId: NCBI__GCA_025059945.1
pathwayId: cys
ruleId: from-serine-homocysteine
requiredPathwayId: met
requiredRuleId: homocysteine
comment:
Cysteine biosynthesis via the reverse transsulfuration pathway requires homocysteine, which is an intermediate in methionine biosynthesis. Homocysteine is also an intermediate in the S-adenosylmethionine cycle, so many organisms that cannot synthesize methionine can convert it to homocysteine.


