# Candidate

orgId: NCBI__GCA_028287785.1
pathwayId: his
stepId: hisA
locusId: MDB5035027.1
sysName: JWQ98_2268
desc: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
curatedIds: reanno::Cola:Echvi_2515
hmmId: TIGR00007
hmmDesc:
hisA: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase (EC 5.3.1.16)


orgId: NCBI__GCA_028287785.1
pathwayId: his
stepId: hisH
locusId: MDB5035026.1
sysName: JWQ98_2267
desc: imidazole glycerol phosphate synthase subunit HisH
hmmId: TIGR01855
hmmDesc: hisH: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit (EC 2.4.2.-)
curatedIds:
CharProtDB::CH_024511,SwissProt::P60595,ecocyc::GLUTAMIDOTRANS-MONOMER,metacyc::GLUTAMIDOTRANS-MONOMER


orgId: NCBI__GCA_028287785.1
pathwayId: trp
stepId: trpD_1
locusId: MDB5034237.1
sysName: JWQ98_1478
desc: hypothetical protein
curatedIds: curated2:O28670
otherIds:
BRENDA::P04079,CharProtDB::CH_003303,SwissProt::P04079,ecocyc::GMP-SYN-MONOMER,metacyc::GMP-SYN-MONOMER


# RequirementNotMet

orgId: NCBI__GCA_028287785.1
pathwayId: cys
ruleId: from-serine-homocysteine
requiredPathwayId: met
requiredRuleId: homocysteine
comment:
Cysteine biosynthesis via the reverse transsulfuration pathway requires homocysteine, which is an intermediate in methionine biosynthesis. Homocysteine is also an intermediate in the S-adenosylmethionine cycle, so many organisms that cannot synthesize methionine can convert it to homocysteine.


