# Candidate

orgId: NCBI__GCF_000154725.1
pathwayId: his
stepId: hisA
locusId: WP_007093684.1
sysName: KAOT1_RS05235
desc: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
curatedIds: reanno::Btheta:350907
hmmId: TIGR00007
hmmDesc:
hisA: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase (EC 5.3.1.16)


orgId: NCBI__GCF_000154725.1
pathwayId: his
stepId: hisH
locusId: WP_007093683.1
sysName: KAOT1_RS05230
desc: imidazole glycerol phosphate synthase subunit HisH
hmmId: TIGR01855
hmmDesc: hisH: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit (EC 2.4.2.-)
curatedIds:
CharProtDB::CH_024511,SwissProt::P60595,ecocyc::GLUTAMIDOTRANS-MONOMER,metacyc::GLUTAMIDOTRANS-MONOMER


orgId: NCBI__GCF_000154725.1
pathwayId: met
stepId: metH
locusId: WP_007095098.1
sysName: KAOT1_RS12060
desc: methionine synthase
locusId2: WP_007095099.1
sysName2: KAOT1_RS12065
desc2: homocysteine S-methyltransferase family protein
hmmId: TIGR02082
hmmDesc: metH: methionine synthase (EC 2.1.1.13)
curatedIds:
CharProtDB::CH_090726,SwissProt::P13009,ecocyc::HOMOCYSMETB12-MONOMER,metacyc::HOMOCYSMETB12-MONOMER


orgId: NCBI__GCF_000154725.1
pathwayId: phe
stepId: PPYAT
locusId: WP_007095718.1
sysName: KAOT1_RS15080
desc: branched-chain amino acid transaminase
curatedIds:
CharProtDB::CH_024500,ecocyc::BRANCHED-CHAINAMINOTRANSFER-MONOMER,metacyc::BRANCHED-CHAINAMINOTRANSFER-MONOMER


orgId: NCBI__GCF_000154725.1
pathwayId: phe
stepId: cmutase
locusId: WP_007095087.1
sysName: KAOT1_RS12010
desc: prephenate dehydratase
otherIds: reanno::Cola:Echvi_0123
curatedIds:
CharProtDB::CH_024084,SwissProt::P0A9J8,ecocyc::CHORISMUTPREPHENDEHYDRAT-MONOMER,metacyc::CHORISMUTPREPHENDEHYDRAT-MONOMER


orgId: NCBI__GCF_000154725.1
pathwayId: thr
stepId: thrC
locusId: WP_007094425.1
sysName: KAOT1_RS08800
desc: threonine synthase
hmmId: TIGR00260
hmmDesc: thrC: threonine synthase (EC 4.2.3.1)
otherIds: SwissProt::Q80W22
curatedIds:
BRENDA::P00934,CharProtDB::CH_002114,SwissProt::P00934,ecocyc::THRESYN-MONOMER,metacyc::THRESYN-MONOMER


# RequirementNotMet

orgId: NCBI__GCF_000154725.1
pathwayId: cys
ruleId: from-serine-homocysteine
requiredPathwayId: met
requiredRuleId: homocysteine
comment:
Cysteine biosynthesis via the reverse transsulfuration pathway requires homocysteine, which is an intermediate in methionine biosynthesis. Homocysteine is also an intermediate in the S-adenosylmethionine cycle, so many organisms that cannot synthesize methionine can convert it to homocysteine.


