# Candidate

orgId: NCBI__GCF_000236705.1
pathwayId: cys
stepId: cysE
locusId: WP_014203608.1
sysName: OWEHO_RS16335
desc: acyltransferase
curatedIds: curated2:P71405
otherIds:
CharProtDB::CH_088634,SwissProt::P77791,ecocyc::MALTACETYLTRAN-MONOMER,metacyc::MALTACETYLTRAN-MONOMER


orgId: NCBI__GCF_000236705.1
pathwayId: his
stepId: hisA
locusId: WP_014203787.1
sysName: OWEHO_RS17240
desc: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
curatedIds: reanno::Cola:Echvi_2515
hmmId: TIGR00007
hmmDesc:
hisA: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase (EC 5.3.1.16)


orgId: NCBI__GCF_000236705.1
pathwayId: his
stepId: hisH
locusId: WP_014203788.1
sysName: OWEHO_RS17245
desc: imidazole glycerol phosphate synthase subunit HisH
hmmId: TIGR01855
hmmDesc: hisH: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit (EC 2.4.2.-)
curatedIds:
CharProtDB::CH_024511,SwissProt::P60595,ecocyc::GLUTAMIDOTRANS-MONOMER,metacyc::GLUTAMIDOTRANS-MONOMER


orgId: NCBI__GCF_000236705.1
pathwayId: met
stepId: metH
locusId: WP_041627673.1
sysName: OWEHO_RS15600
desc: methionine synthase
locusId2: WP_014203454.1
sysName2: OWEHO_RS15590
desc2: homocysteine S-methyltransferase family protein
hmmId: TIGR02082
hmmDesc: metH: methionine synthase (EC 2.1.1.13)
curatedIds:
CharProtDB::CH_090726,SwissProt::P13009,ecocyc::HOMOCYSMETB12-MONOMER,metacyc::HOMOCYSMETB12-MONOMER


# RequirementNotMet

orgId: NCBI__GCF_000236705.1
pathwayId: cys
ruleId: from-serine-homocysteine
requiredPathwayId: met
requiredRuleId: homocysteine
comment:
Cysteine biosynthesis via the reverse transsulfuration pathway requires homocysteine, which is an intermediate in methionine biosynthesis. Homocysteine is also an intermediate in the S-adenosylmethionine cycle, so many organisms that cannot synthesize methionine can convert it to homocysteine.


