# Candidate

orgId: NCBI__GCF_002954355.1
pathwayId: his
stepId: hisA
locusId: WP_105018577.1
sysName: BST93_RS05755
desc: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
curatedIds: reanno::Btheta:350907
hmmId: TIGR00007
hmmDesc:
hisA: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase (EC 5.3.1.16)


orgId: NCBI__GCF_002954355.1
pathwayId: trp
stepId: trpD_1
locusId: WP_105018589.1
sysName: BST93_RS06965
desc: glutamine-hydrolyzing GMP synthase
curatedIds: BRENDA::P09786,SwissProt::P09786,metacyc::MONOMER-16008
otherIds:
BRENDA::P04079,CharProtDB::CH_003303,SwissProt::P04079,ecocyc::GMP-SYN-MONOMER,metacyc::GMP-SYN-MONOMER


# RequirementNotMet

orgId: NCBI__GCF_002954355.1
pathwayId: cys
ruleId: from-serine-homocysteine
requiredPathwayId: met
requiredRuleId: homocysteine
comment:
Cysteine biosynthesis via the reverse transsulfuration pathway requires homocysteine, which is an intermediate in methionine biosynthesis. Homocysteine is also an intermediate in the S-adenosylmethionine cycle, so many organisms that cannot synthesize methionine can convert it to homocysteine.


