# Candidate

orgId: NCBI__GCF_003234935.1
pathwayId: cys
stepId: cysE
locusId: WP_111061539.1
sysName: DNU06_RS17995
desc: acyltransferase
curatedIds: SwissProt::Q8S895
otherIds:
CharProtDB::CH_088634,SwissProt::P77791,ecocyc::MALTACETYLTRAN-MONOMER,metacyc::MALTACETYLTRAN-MONOMER


orgId: NCBI__GCF_003234935.1
pathwayId: his
stepId: hisA
locusId: WP_111064351.1
sysName: DNU06_RS15190
desc: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
curatedIds: reanno::Cola:Echvi_2515
hmmId: TIGR00007
hmmDesc:
hisA: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase (EC 5.3.1.16)


orgId: NCBI__GCF_003234935.1
pathwayId: met
stepId: metH
locusId: WP_111061429.1
sysName: DNU06_RS01465
desc: methionine synthase
locusId2: WP_111061427.1
sysName2: DNU06_RS01455
desc2: homocysteine S-methyltransferase family protein
hmmId: TIGR02082
hmmDesc: metH: methionine synthase (EC 2.1.1.13)
curatedIds:
CharProtDB::CH_090726,SwissProt::P13009,ecocyc::HOMOCYSMETB12-MONOMER,metacyc::HOMOCYSMETB12-MONOMER


# RequirementNotMet

orgId: NCBI__GCF_003234935.1
pathwayId: cys
ruleId: from-serine-homocysteine
requiredPathwayId: met
requiredRuleId: homocysteine
comment:
Cysteine biosynthesis via the reverse transsulfuration pathway requires homocysteine, which is an intermediate in methionine biosynthesis. Homocysteine is also an intermediate in the S-adenosylmethionine cycle, so many organisms that cannot synthesize methionine can convert it to homocysteine.


