# Candidate

orgId: NCBI__GCF_003353425.1
pathwayId: chorismate
stepId: fbp
locusId: WP_115124360.1
sysName: C8D94_RS12805
desc: class II fructose-bisphosphate aldolase
hmmId: TIGR01520
hmmDesc: fbaA: fructose-bisphosphate aldolase, class II (EC 4.1.2.13)
curatedIds:
CharProtDB::CH_024118,SwissProt::P0AB71,ecocyc::FRUCTBISALD-CLASSII-MONOMER,metacyc::FRUCTBISALD-CLASSII-MONOMER


orgId: NCBI__GCF_003353425.1
pathwayId: gly
stepId: glyA
locusId: WP_115123860.1
sysName: C8D94_RS10300
desc: serine hydroxymethyltransferase
curatedIds:
BRENDA::P0A825,CharProtDB::CH_024268,SwissProt::P0A825,ecocyc::GLYOHMETRANS-MONOMER,metacyc::GLYOHMETRANS-MONOMER


orgId: NCBI__GCF_003353425.1
pathwayId: his
stepId: hisA
locusId: WP_115123706.1
sysName: C8D94_RS09435
desc: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
curatedIds: reanno::Btheta:350907
hmmId: TIGR00007
hmmDesc:
hisA: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase (EC 5.3.1.16)


orgId: NCBI__GCF_003353425.1
pathwayId: his
stepId: hisH
locusId: WP_115123707.1
sysName: C8D94_RS09440
desc: imidazole glycerol phosphate synthase subunit HisH
hmmId: TIGR01855
hmmDesc: hisH: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit (EC 2.4.2.-)
curatedIds:
CharProtDB::CH_024511,SwissProt::P60595,ecocyc::GLUTAMIDOTRANS-MONOMER,metacyc::GLUTAMIDOTRANS-MONOMER


orgId: NCBI__GCF_003353425.1
pathwayId: met
stepId: metH
locusId: WP_115122875.1
sysName: C8D94_RS05575
desc: methionine synthase
locusId2: WP_115122873.1
sysName2: C8D94_RS05565
desc2: homocysteine S-methyltransferase family protein
hmmId: TIGR02082
hmmDesc: metH: methionine synthase (EC 2.1.1.13)
curatedIds:
CharProtDB::CH_090726,SwissProt::P13009,ecocyc::HOMOCYSMETB12-MONOMER,metacyc::HOMOCYSMETB12-MONOMER


orgId: NCBI__GCF_003353425.1
pathwayId: phe
stepId: PPYAT
locusId: WP_115122448.1
sysName: C8D94_RS03230
desc: aminotransferase class IV
curatedIds:
CharProtDB::CH_024500,ecocyc::BRANCHED-CHAINAMINOTRANSFER-MONOMER,metacyc::BRANCHED-CHAINAMINOTRANSFER-MONOMER


orgId: NCBI__GCF_003353425.1
pathwayId: trp
stepId: trpD_1
locusId: WP_115124053.1
sysName: C8D94_RS11045
desc: glutamine-hydrolyzing GMP synthase
curatedIds: uniprot:B8DM46_DESVM
otherIds:
BRENDA::P04079,CharProtDB::CH_003303,SwissProt::P04079,ecocyc::GMP-SYN-MONOMER,metacyc::GMP-SYN-MONOMER


# RequirementNotMet

orgId: NCBI__GCF_003353425.1
pathwayId: cys
ruleId: from-serine-homocysteine
requiredPathwayId: met
requiredRuleId: homocysteine
comment:
Cysteine biosynthesis via the reverse transsulfuration pathway requires homocysteine, which is an intermediate in methionine biosynthesis. Homocysteine is also an intermediate in the S-adenosylmethionine cycle, so many organisms that cannot synthesize methionine can convert it to homocysteine.


