# Candidate

orgId: NCBI__GCF_003991135.1
pathwayId: cys
stepId: cysE
locusId: WP_127017920.1
sysName: BBF96_RS15125
curatedIds: curated2:Q56002
otherIds: SwissProt::Q97R46
desc:
bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU


orgId: NCBI__GCF_003991135.1
pathwayId: his
stepId: hisA
locusId: WP_127017375.1
sysName: BBF96_RS11970
desc: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
curatedIds: reanno::Caulo:CCNA_03852
hmmId: TIGR00007
hmmDesc:
hisA: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase (EC 5.3.1.16)


# RequirementNotMet

orgId: NCBI__GCF_003991135.1
pathwayId: cys
ruleId: from-serine-homocysteine
requiredPathwayId: met
requiredRuleId: homocysteine
comment:
Cysteine biosynthesis via the reverse transsulfuration pathway requires homocysteine, which is an intermediate in methionine biosynthesis. Homocysteine is also an intermediate in the S-adenosylmethionine cycle, so many organisms that cannot synthesize methionine can convert it to homocysteine.


