# Candidate

orgId: NCBI__GCF_014524565.1
pathwayId: met
stepId: metH
locusId: WP_210757920.1
sysName: H4K34_RS13515
desc: methionine synthase
locusId2: WP_210757919.1
sysName2: H4K34_RS13510
desc2: homocysteine S-methyltransferase family protein
hmmId: TIGR02082
hmmDesc: metH: methionine synthase (EC 2.1.1.13)
curatedIds:
CharProtDB::CH_090726,SwissProt::P13009,ecocyc::HOMOCYSMETB12-MONOMER,metacyc::HOMOCYSMETB12-MONOMER


orgId: NCBI__GCF_014524565.1
pathwayId: phe
stepId: PPYAT
locusId: WP_210757976.1
sysName: H4K34_RS13810
desc: aminotransferase class IV
curatedIds:
CharProtDB::CH_024500,ecocyc::BRANCHED-CHAINAMINOTRANSFER-MONOMER,metacyc::BRANCHED-CHAINAMINOTRANSFER-MONOMER


orgId: NCBI__GCF_014524565.1
pathwayId: trp
stepId: trpD_1
locusId: WP_210758240.1
sysName: H4K34_RS15195
desc: glutamine-hydrolyzing GMP synthase
curatedIds: BRENDA::P09786,SwissProt::P09786,metacyc::MONOMER-16008
otherIds:
BRENDA::P04079,CharProtDB::CH_003303,SwissProt::P04079,ecocyc::GMP-SYN-MONOMER,metacyc::GMP-SYN-MONOMER


# RequirementNotMet

orgId: NCBI__GCF_014524565.1
pathwayId: cys
ruleId: from-serine-homocysteine
requiredPathwayId: met
requiredRuleId: homocysteine
comment:
Cysteine biosynthesis via the reverse transsulfuration pathway requires homocysteine, which is an intermediate in methionine biosynthesis. Homocysteine is also an intermediate in the S-adenosylmethionine cycle, so many organisms that cannot synthesize methionine can convert it to homocysteine.


