# Candidate

orgId: NCBI__GCF_900176425.1
pathwayId: chorismate
stepId: tpiA
locusId: WP_084017436.1
sysName: B8977_RS09315
desc: triose-phosphate isomerase
hmmId: TIGR00419
hmmDesc: tpiA: triose-phosphate isomerase (EC 5.3.1.1)
curatedIds:
BRENDA::P0A858,CharProtDB::CH_024675,SwissProt::B1XB85,SwissProt::P0A858,ecocyc::TPI-MONOMER,metacyc::TPI-MONOMER


orgId: NCBI__GCF_900176425.1
pathwayId: cys
stepId: cysE
locusId: WP_084017497.1
sysName: B8977_RS15290
desc: hypothetical protein
curatedIds: BRENDA::A0A0H2UNY1
otherIds:
BRENDA::P07464,SwissProt::P07464,ecocyc::GALACTOACETYLTRAN-MONOMER,metacyc::GALACTOACETYLTRAN-MONOMER


orgId: NCBI__GCF_900176425.1
pathwayId: his
stepId: hisA
locusId: WP_084016510.1
sysName: B8977_RS04650
desc: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
curatedIds: reanno::Cola:Echvi_2515
hmmId: TIGR00007
hmmDesc:
hisA: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase (EC 5.3.1.16)


orgId: NCBI__GCF_900176425.1
pathwayId: his
stepId: hisH
locusId: WP_084016511.1
sysName: B8977_RS04655
desc: imidazole glycerol phosphate synthase subunit HisH
hmmId: TIGR01855
hmmDesc: hisH: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit (EC 2.4.2.-)
curatedIds:
CharProtDB::CH_024511,SwissProt::P60595,ecocyc::GLUTAMIDOTRANS-MONOMER,metacyc::GLUTAMIDOTRANS-MONOMER


orgId: NCBI__GCF_900176425.1
pathwayId: met
stepId: metH
locusId: WP_084017444.1
sysName: B8977_RS09355
desc: methionine synthase
locusId2: WP_084017443.1
sysName2: B8977_RS09350
desc2: homocysteine S-methyltransferase family protein
hmmId: TIGR02082
hmmDesc: metH: methionine synthase (EC 2.1.1.13)
otherIds: SwissProt::O06745
curatedIds:
CharProtDB::CH_090726,SwissProt::P13009,ecocyc::HOMOCYSMETB12-MONOMER,metacyc::HOMOCYSMETB12-MONOMER


orgId: NCBI__GCF_900176425.1
pathwayId: trp
stepId: trpD_1
locusId: WP_084016567.1
sysName: B8977_RS04980
desc: glutamine-hydrolyzing GMP synthase
curatedIds: curated2:O28670
otherIds:
BRENDA::P04079,CharProtDB::CH_003303,SwissProt::P04079,ecocyc::GMP-SYN-MONOMER,metacyc::GMP-SYN-MONOMER


# RequirementNotMet

orgId: NCBI__GCF_900176425.1
pathwayId: cys
ruleId: from-serine-homocysteine
requiredPathwayId: met
requiredRuleId: homocysteine
comment:
Cysteine biosynthesis via the reverse transsulfuration pathway requires homocysteine, which is an intermediate in methionine biosynthesis. Homocysteine is also an intermediate in the S-adenosylmethionine cycle, so many organisms that cannot synthesize methionine can convert it to homocysteine.


