>8500289 DvMF_1045 glycine betaine/L-proline ABC transporter, ATPase subunit (RefSeq)
MAKIEIRDLTKIFGPVPEKALAMVRAGKPKDEIYKRTKHAVGVNRATFDVDEGEIVVVMGLSGSGKSTLVRCLNRLIEPTDGTVRIDGTDVTTLSVKDLRALRQRTFGMVFQNFALFPHRTVLENAEYGLEVMGAAKATRRDKAAEALARVGLAGWEAARPGQLSGGMQQRVGLARALALDPDILLMDEAFSALDPLIRRDMQDELLRLQDDVRKTIVFISHDLDEALKIGDRIVLMRDGAVVQVGTPEDILTSPADDYVARFVADVDIARVLTAGTVMKRSEAVAVLGVDGPRTALRKMRNHAIATLFVLDRNHKLVGLVTADDIVEHLAGGERDLAAIMRTDITTVSTDAPASELIPLMAGLPHPLAVTDERGRLAGVIVRGLLLGALAERGGNA
>TCDB__Q8U4S5 OtaA, component of The salt-induced glycine betaine OtaABC transporter (Methanosarcina mazei)
MSEIAKIEIKNLTKIFGKNPQEVLSLLKGGHTKNEIFEKTKQTVGLNNINFDVYDGEIFVLMGLSGSGKSTLLRCINRLINPTSGKILIDGQDISVMDAEQLRKVRRTKLGMVFQNFALLPHRTVLDNVAYGLEIQGVPKNERYSKAVEAINTVGLKGYEDSKITQLSGGMKQRVGLARALANDPDILLMDEAFSALDPLIRNEMQDELLSLEDKLQKTIVFVSHDLDEALKLGDRIALMKDGEIVQIGTPEEILTNPADNYVSQFVKGVDRSKVLTAENVMWRPEPLVSINSGPRVAVQLMKEYGISSIFVVEGKNRLLKGIIMIDDAVEALKSKKNLESIIREIPSIPLDMPLSEIIPLIANSSYPLPVVDESRKLKGIIIRGTVLGALAMSEDVPEEASAGEGEPVQDKNKEILDNKGQQESPASEKGLSSEVEDISQKSENVEVKM
>SwissProt__P46920 Glycine betaine transport ATP-binding protein OpuAA; Quaternary-amine-transporting ATPase; EC 7.6.2.9 (Bacillus subtilis (strain 168))
MSVDEKPIKIKVEKVSKIFGKQTKKAVQMLANGKTKKEILKATGSTVGVNQADFEVYDGEIFVIMGLSGSGKSTLVRMLNRLIEPTAGNIYIDGDMITNMSKDQLREVRRKKISMVFQKFALFPHRTILENTEYGLELQGVDKQERQQKALESLKLVGLEGFEHQYPDQLSGGMQQRVGLARALTNDPDILLMDEAFSALDPLIRKDMQDELLDLHDNVGKTIIFITHDLDEALRIGDRIVLMKDGNIVQIGTPEEILMNPSNEYVEKFVEDVDLSKVLTAGHIMKRAETVRIDKGPRVALTLMKNLGISSIYAVDKQKKLLGVIYASDAKKAAESDLSLQDILNTEFTTVPENTYLTEIFDVVSDANIPIAVVDEKQRMKGIVVRGALIGALAGNNEYINAEGTNEQTQDPSAQEVK
>SwissProt__Q9RR46 Glycine betaine/carnitine transport ATP-binding protein GbuA; EC 7.6.2.9 (Listeria monocytogenes serotype 1/2a (strain 10403S))
MSKIKVEELTKIFGKKASKASSLLSQGKSKTDILKETGATIGVNKASFSVEEGEIFVIMGLSGSGKSTLVRLLNRLIEPTSGKIWLDGKELSSLNKKELLEVRRKSMSMVFQNFGLFPNRTINRNVEYGLEIQGMDKEEREKNAAESLALVGLAGYGDQYPSQLSGGMQQRVGLARALANNPDILLMDEAFSALDPLNRKDMQDQLLDLQDKMKKTIIFITHDLDEALRIGDHIMIMRDGSVVQTGSPEEILAHPANEYVEKFIEDVDRSKVYTASNVMIRPEIVNFEKDGPRVALKRMREAGTSSVFVVKRNRELVGIVHAAEVSKLVKENITSLETALHRDVPTTGLDTPLAEIMDTISTTTIPIAVTEDGKLKGIIIRGSVLAALSGNEVNVNA
>TCDB__Q9RQ06 BusAA, component of Uptake system for glycine-betaine (high affinity) and proline (low affinity) (OpuAA-OpuABC) or BusAA-ABC of Lactococcus lactis). BusAA, the ATPase subunit, has a C-terminal tandem cystathionine β-synthase (CBS) domain which is the cytoplasmic K+ sensor for osmotic stress (osmotic strength)while the BusABC subunit has the membrane and receptor domains fused to each other (Biemans-Oldehinkel et al., 2006; Mahmood et al., 2006; Gul et al. 2012). An N-terminal amphipathic α-helix of OpuA is necessary for high activity but is not critical for biogenesis or the ionic regulation of transport (Lactococcus lactis)
MPVKVKIEHLTKIFGKRIKTALTMVEQGEPKNEILKKTGATVGVYDTNFEINEGEIFVIMGLSGSGKSTLLRLLNRLIEPTSGKIFIDDQDVATLNKEDLLQVRRKSMSMVFQNFGLFPHRTILENTEYGLEVQNVPKEERRKRAEKALDNANLLDFKDQYPKQLSGGMQQRVGLARALANDPEILLMDEAFSALDPLIRREMQDELLELQAKFQKTIIFVSHDLNEALRIGDRIAIMKDGKIMQIGTGEEILTNPANDYVKTFVEDVDRAKVITAENIMIPALTTNIDVDGPSVALKKMKTEEVSSLMAVDRKRQFRGVVTSEQAIAARKNNQSLKDVMTTDVGTVTKEMLVRDILPIIYDAPTPLAVVDDQGYLKGILIRGIVLEALADIPDEVEEIEKEEEKND
>biolip__7aheC Opua inhibited inward facing
VKIKIEHLTKIFGKRIKTALTMVEKGEPKNEILKKTGATVGVYDTNFEINEGEIFVIMGLSGSGKSTLLRLLNRLIEPTSGKIFIDNQDVATLNKEDLLQVRRKTMSMVFQNFGLFPHRTILENTEYGLEVQNVPKEERRKRAEKALDNANLLDFKDQYPKQLSGGMQQRVGLARALANDPEILLMDEAFSALDPLIRREMQDELLELQAKFQKTIIFVSHDLNEALRIGDRIAIMKDGKIMQIGTGEEILTNPANDYVKTFVEDTAENIMIPALTTNIDVDGPSVALKKMKTEEVSSLMAVDKKRQFRGVVTSEQAIAARKNNQPLKDVMTTDVGTVSKEMLVRDILPIIYDAPTPLAVVDDNGFLKGVLIRGSVLEALAD
>PDB_7ahh_C Opua inhibited inward-facing, sbd docked
VKIKIEHLTKIFGKRIKTALTMVEKGEPKNEILKKTGATVGVYDTNFEINEGEIFVIMGLSGSGKSTLLRLLNRLIEPTS
GKIFIDNQDVATLNKEDLLQVRRKTMSMVFQNFGLFPHRTILENTEYGLEVQNVPKEERRKRAEKALDNANLLDFKDQYP
KQLSGGMQQRVGLARALANDPEILLMDEAFSALDPLIRREMQDELLELQAKFQKTIIFVSHDLNEALRIGDRIAIMKDGK
IMQIGTGEEILTNPANDYVKTFVEDTAENIMIPALTTNIDVDGPSVALKKMKTEEVSSLMAVDKKRQFRGVVTSEQAIAA
RKNNQPLKDVMTTDVGTVSKEMLVRDILPIIYDAPTPLAVVDDNGFLKGVLIRGSVLEALAD
>BRENDA__A0A077T7Z1 ABC-type quaternary amine transporter (subunit 1/3) (EC 7.6.2.9) (Vibrio anguillarum serotype O1)
MSPVLEVKNLYKVFGETPQQAFPLLEKGLDKDQIFEQTGLTVGVKDVSLSINEGEIFVIMGLSGSGKSTLVRLLNRLIEPTQGSVLLKGKDIAHISEQELRDVRRKNISMVFQNFALMPHMTVLENAAFGLELSGVVAHERNKSAKEALARVGLDAYCESFPDELSGGMKQRVGLARALANDPDILLMDEAFSALDPLIRTEMQDELIRLQNDDKRTIVFISHDLDEAMRIGDRIAIMQDGIVVQTGTPDEILHHPANDYVSSFFRGVNVASVFSAKDIARKKPAAVFKKHDNDGPAAAMQLLMDHDRDYGIVVDRTNKYSGIVSLDSLKQALKQQTSLSAALLPDIVTVDPELSVSELISQVAEVPYAVPVVDQQGNYYGVITKSRLLQTLDRE
>SwissProt__P17328 Glycine betaine/proline betaine transport system ATP-binding protein ProV (Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720))
MAIKLEVKNLYKIFGEHPQRAFKYIEKGLSKEQILEKTGLSLGVKDASLAIEEGEIFVIMGLSGSGKSTMVRLLNRLIEPTRGQVLIDGVDIAKISDAELREVRRKKIAMVFQSFALMPHMTVLDNTAFGMELAGIAAQERREKALDALRQVGLENYAHAYPDELSGGMRQRVGLARALAINPDILLMDEAFSALDPLIRTEMQDELVKLQAKHQRTIVFISHDLDEAMRIGDRIAIMQNGEVVQVGTPDEILNNPANDYVRTFFRGVDISQVFSAKDIARRSPVGLIRKTPGFGPRSALKLLQDEDREYGYVIERGNKFVGVVSIDSLKAALSQAQGIEAALIDDPLVVDAQTPLSELLSHVGQAPCAVPVVDEEHQYVGIISKRMLLQALDREGGNNG
>ecocyc__PROV-MONOMER glycine betaine ABC transporter ATP binding subunit ProV (EC 7.6.2.9) (Escherichia coli K-12 substr. MG1655)
MAIKLEIKNLYKIFGEHPQRAFKYIEQGLSKEQILEKTGLSLGVKDASLAIEEGEIFVIMGLSGSGKSTMVRLLNRLIEPTRGQVLIDGVDIAKISDAELREVRRKKIAMVFQSFALMPHMTVLDNTAFGMELAGINAEERREKALDALRQVGLENYAHSYPDELSGGMRQRVGLARALAINPDILLMDEAFSALDPLIRTEMQDELVKLQAKHQRTIVFISHDLDEAMRIGDRIAIMQNGEVVQVGTPDEILNNPANDYVRTFFRGVDISQVFSAKDIARRTPNGLIRKTPGFGPRSALKLLQDEDREYGYVIERGNKFVGAVSIDSLKTALTQQQGLDAALIDAPLAVDAQTPLSELLSHVGQAPCAVPVVDEDQQYVGIISKGMLLRALDREGVNNG
>SwissProt__E0SCY1 Glycine betaine/choline transport system ATP-binding protein OusV (Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)))
MAIKLEVTHLYKIFGEHPERAFRLLEQGLSKDQIFEKTGLTVGVKDASLAIEEGEIFVIMGLSGSGKSTLVRLLNRLIEPTRGQVLIDGEDISRLPDGALRAVRRKQISMVFQSFALMPHLNILDNTAFGMDLAGVPRAEREQKALNALQQVGLETYAHAYPDELSGGMRQRVGLARALANDPDILLMDEAFSALDPLIRTEMQDELIKLQARRQRTIVFISHDLDEAMRIGDRIAIMHSGEVIQVGTPDEILNNPANDYVRTFFRGVDISHVFTAKDIARRRPVAVIRKTPGVGPRSALRILQEEDREYGYVLERGRKFIGVVSIDSLKQALRGQQPLEQALLPAPAPVPASMSLNELISQVAQAPCAVPVVDENHEYLGIISKGMLLQALDKESTLND
>SwissProt__Q4FL37 Trimethylamine N-oxide transport system ATP-binding protein TmoW; TMAO transport system ATP-binding protein TmoW; EC 7.6.2.9 (Pelagibacter ubique (strain HTCC1062))
MSDPVIKCESVYKIFGSNAKKMLHEANGNVDAKTFQDNGCIVGVNNASFEVVKGEMLVVMGLSGSGKSTLLRCISRLTDATSGKIYIDGQDLLTLNNKELIELRRNKMGMVFQSFALLPHKTVVENIAFPLQIKGIKTQDSINKAMEMVKLVGLDGRENYFPRELSGGQQQRVGIARSLAVEPDIWFLDEPFSALDPLIRKEMQDEFLRLQEKLQKTIMFITHDFDEALRLADRIAIMKDGVIEQLDTPANIVLNPATEYVRKFTEEVPRGKVLKIADLMEKPETENLSDFKVSKNEIIENVAEKILTQEKSVAVTDENNKIVGSVHPSKIIHTVFSREKK
>reanno__pseudo3_N2E3_AO353_07790 ABC transporter for Carnitine, ATPase component (Pseudomonas fluorescens FW300-N2E3)
MSIIRFDNVDVIFSKDPREALKLLDQGMTRDQILKKTGQIVGVEKASLDIEKGEICVLMGLSGSGKSSLLRCINGLNTVSRGKLFVEHEGRQIDIASCTPAELKMMRTKRIAMVFQKFALMPWLTVRENISFGLEMQGRPEKERRQLVDEKLELVGLTQWRNKKPDELSGGMQQRVGLARALAMDADILLMDEPFSALDPLIRQGLQDELLELQRKLHKTIVFVSHDLDEALKLGSRIAIMKDGRIIQYSKPEEIVLNPADDYVRTFVAHTNPLNVLCGRSLMRTLDNCKRINGSVCLDPGGDSWLDLAEGNTIKGARQNGSSLDLQNWVPGQAVEGLGRRPTLVDSNIGMRDALQIRYQTGNKLVLHDNNKVVGILGDSELYHALLGKNLG
>TCDB__Q9HTI8 Probable ATP-binding component of ABC transporter, component of The CbcWV/CbcX (choline)/CaiX (carnitine)/BetX (betaine) transporter with 3 binding receptors for distinct quaternary ammonium compounds. Only the ligand-bound receptor binds to the transporter with high affinity (Pseudomonas aeruginosa)
MTAIRFDHVDVIFGTHTKEALKLLDQGLGRAEILKRTGQVLGVEDACLDVNRGEICVLMGLSGSGKSSLLRCINGLNKVSRGKLLIEHEGSQVDIANCSPATLKAMRTKRIAMVFQKFALMPWLTVAENVGFGLEMQGRPAAERKKLIDEKLELVGLSQWRDKRPDSLSGGMQQRVGLARALAMDGDILLMDEPFSALDPLIRQQLQDELLVLQRQLHKTIVFVSHDLDEALKIGTRIAIMKDGRIIQHGKPEEIVLSPADDYVRTFVAHTNPLNVLCGQSLMRGLDQCIRQNDEICFDQGRDCWIGLSEGDVLKGARQGSNVIDLQRWRQGDPVEKLRREPTLVDVSIRMRDALQIRYQTGHKLVLQEQDRVVGVLGDSELYHALLGKNLG
>reanno__pseudo5_N2C3_1_AO356_13805 ABC transporter for Carnitine, ATPase component (Pseudomonas fluorescens FW300-N2C3)
MSIIRFEDVDVIFSNRPKAALDLLDKGFSRPEILQQTGLIVGVEKASLSIEKGEICVLMGLSGSGKSSLLRCINGLNTVSRGKLFVEHEGRQIDIASCSPAELKMMRTKRIAMVFQKFALMPWLTVRENISFGLEMQGRPEKERRKLVDEKLELVGLTQWRNKKPDELSGGMQQRVGLARALAMDADILLMDEPFSALDPLIRQGLQDELLELQRKLQKTIVFVSHDLDEALKLGTRIAIMKDGKIIQYSKPEEIVLNPADDYVRTFVAHTNPLNVLCGRSLMRTLDNCKRINGSVCLDPGGDSWLDLAEGNTIKGARQNGAVLDLQNWAPGQSVEELGRRPTLVDSNIGMRDALQIRYQTGNKLVLHDNQKVVGILGDSELYHALLGKNLG
>reanno__pseudo6_N2E2_Pf6N2E2_4681 ABC transporter for Carnitine, ATPase component (Pseudomonas fluorescens FW300-N2E2)
MSIIRFEDVDVIFSNRPKAALDLLDKGLSRPEILQQTGLIVGVEKASLSIEKGEICVLMGLSGSGKSSLLRCINGLNTVSRGKLFVEHEGRQIDIASCSPAELKMMRTKRIAMVFQKFALMPWLTVRENISFGLEMQGRPEKERRKLVDEKLELVGLTQWRNKKPDELSGGMQQRVGLARALAMDADILLMDEPFSALDPLIRQGLQDELLELQRKLQKTIVFVSHDLDEALKLGTRIAIMKDGKIIQYSKPEEIVLNPADDYVRTFVAHTNPLNVLCGRSLMRTLDNCKRINGSVCLDPGGDSWLDLAEGNTIKGARQNGAALDLQNWVPGQAVEDLGRRPTLVDSNIGMRDALQIRYQTGNKLVLHDNQQVVGILGDSELYHALLGKNLG
>TCDB__A9CI32 ABC transporter, nucleotide binding/ATPase protein (Proline/glycine betaine), component of High affinity (2mμM) choline uptake porter. The choline binding receptor exhibits a venus fly trap mechanism of substrate binding. (ChoX binds acetyl choline and betaine with low affinity (80μM and 470μM, respectively) (Aktas et al., 2011) (most similar to 3.A.1.12.7) (Agrobacterium tumefaciens (strain C58 / ATCC 33970))
MSDAIIFGNVDIVFGDRPDAALALIDKGSTRDEINAQTGLVLGVANASLSVSEGEILVLMGLSGSGKSTLVRAVNGLAPVVRGSVSVKTKSGYVDPYRCPAKALRDLRMHTVSMVFQQFGLLPWRNVADNVGFGLELSGVPEAERKRMVAEQLELVNLSAWADRKVGELSGGMQQRVGLARAFATGAPILLMDEPFSALDPLIRSRLQDELLEFQSRLKKTILFVSHDLDEAFRIGNRIAMMEGGHIIQCGTPQQIVRQPATPYVADFVQNMNPISMLTAADVMKRGVDERSGRLTVAATALPSSPLIDILDALSKHAGAIGVVDNGAIIGTISADEVVAGLTRHRKK
>TCDB__Q92N35 ChoV, component of High affinity (3 μM) choline-specific uptake system (Rhizobium meliloti (Sinorhizobium meliloti))
MSDAVVFKNVDIIFGKNPQLAVQMVDQGKTRDEIGAATGLVLGVAGASLTINEGEILVLMGLSGSGKSTLLRAVNGLAPVVRGEVEVKTANGSLNPYRCNAKSLRDFRMHTVSMVFQQFALLPWRTVADNVGFGLELAGVADAERRKRVGEQLELVNLAKWADRKVNELSGGMQQRVGLARAFATGAPILLMDEPFSALDPLIRTRLQDELLEFQRRLKKTIIFVSHDLDEAFRIGNRIAIMEGGRIIQCGTPQEIVKKPANQYVADFVQHMNPITMLTAKDVMQTGVGRAAASTGVSATARPTTPLVDILDAMSRQPGSIGVVDNGSVVGTIDAQNIVEGLTRHRNKG
>SwissProt__O34992 Glycine betaine/carnitine/choline transport ATP-binding protein OpuCA (Bacillus subtilis (strain 168))
MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTTMKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPKLLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMDEPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVGTPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMREKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRKILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI
>SwissProt__Q45460 Choline transport ATP-binding protein OpuBA (Bacillus subtilis (strain 168))
MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTTMKMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPKLLKWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMDEPFGALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVGTPDDILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLMRQERVDSLLVVNDERVLQGYVDVEIIDQCRKKANLVSEVLHEDIYTVLGGTLLRDTVRKILKRGVKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS
>SwissProt__G2JZ44 Carnitine transport ATP-binding protein OpuCA; EC 7.6.2.9 (Listeria monocytogenes serotype 1/2a (strain 10403S))
MLKFEHVTKTYKGGKKAVNDLTLNIDKGEFVCFIGPSGCGKTTTMKMINRLIEPTEGKIFINDKDIMAEDPVKLRRSIGYVIQQIGLMPHMTIRENIVLVPKLLKWSEEKKQERAKELIKLVDLPEEFLDRYPYELSGGQQQRIGVLRALAAEQNLILMDEPFGALDPITRDSLQEEFKNLQKELGKTIIFVTHDMDEAIKLADRIVIMKDGEIVQFDTPDEILRNPANSFVEDFIGKDRLIEAKPDVTQVAQIMNTNPVSITADKSLQAAITVMKEKRVDTLLVVDEGNVLKGFIDVEQIDLNRRTATSVMDIIEKNVFYVYEDTLLRDTVQRILKRGYKYIPVVDKDKRLVGIVTRASLVDIVYDSIWGTLEDATENQEEQADSKTTEPEMKQEG
>SwissProt__Q8ZPK4 Osmoprotectant import ATP-binding protein OsmV; EC 7.6.2.- (Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720))
MIKLENLTKQFVQKKGQPLKAVDNVNLNVPEGEMCVLLGPSGCGKTTTLKMINRLIAPSSGNILINGENTNDMDAVTLRRNIGYVIQQIGLFPNMTIEENITVVPRMLGWDKARCKQRAEELMDMVALDARKFLHRYPKEMSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINREVIQNQFLDMQRKLKKTVMLVSHDIDEALKLGDRIAVFRQGRIVQCASPDELLAKPANEFVGSFVGQDRTLKRLLLVSAGDVTDQQPTITARPSTPLSEAFGIMDDHDIRAITVIDNDGKPLGFVKRREARNASGICADITHPFRITGKAEDNLRIVLSRLYESNTSWMPIVDEDGRYNGEISQDYIADYLSSGRTRRALNIHENS
>TCDB__Q1M7Q1 Putative ABC transporter component, component of The γ-aminobutyrate (GABA) uptake system, GtsABCD (Rhizobium leguminosarum bv. viciae (strain 3841))
MKEPFLQIRGIRKEYGPVVAVHDVNLDVRRGEFLTFLGPSGSGKSTTLYILAGFETPTKGDITLEGKTLLATPSHKRNIGMVFQRYTLFPHLTVGENIAFPLKVRRKSKAEVDSKVKEMLRLVRLEGFEDRKPAQMSGGQQQRVALARALAYDPPVLLMDEPLSALDKKLREEIQHEIRRIHQQTEVTILYVTHDQEEALRLSDRIAVFSKGVIDQIGTGPELYANPRTRFVAEFIGDSDFISCDLLSSSDGQATISLGGGSVFNHIPVHGKGTSGTRAALMLRPERIRLSRNQAAGAGLAATVSDITFLGNNIHVSTETATGEALAVRLPFGHEAIAGLSRGDIVHLNFDPGAAHVFC