>H281DRAFT_05652 FitnessBrowser__Burk376:H281DRAFT_05652 MSIKIRKLDSTARDFQKSLHAVLAFEASEDEAIERSVAQILSDVKARGDAAVLEYTNRFDRLSANSVAALELPMSELEAALEGLEPKRRAALEAAAARVRGYHEKQKIECGSHSWQYTEADGTVLGQKVTPLDRAGIYVPGGKAAYPSSVLMNAIPARVAGVREIVMVVPTPDGVKNPLVLAAALLGGVDRVFTIGGAQAVGALAYGTQTVPAVDKICGPGNAYVASAKRRVFGTVGIDMIAGPSEILVLCDGTTDPRWVAMDLFSQAEHDELAQSILLCPDDAFIGRVNDAINELLPTMPRRDVIQASLEGRGALIKVRDMAEACAIANDIAPEHLEISALEPHQWGQLIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFFKRSSVIEVSAEGAQTLGEIAAELAYGEGLQAHARSAEYRMRHSG >BRENDA__Q8G2R2 histidinol dehydrogenase (EC 1.1.1.23) (Brucella suis bv. 1) MVTTLRQTDPDFEQKFAAFLSGKREVSEDVDRAVREIVDRVRREGDSALLDYSRRFDRIDLEKTGIAVTEAEIDAAFDAAPASTVEALKLARDRIEKHHARQLPKDDRYTDALGVELGSRWTAIEAVGLYVPGGTASYPSSVLMNAMPAKVAGVDRIVMVVPAPDGNLNPLVLVAARLAGVSEIYRVGGAQAIAALAYGTETIRPVAKIVGPGNAYVAAAKRIVFGTVGIDMIAGPSEVLIVADKDNNPDWIAADLLAQAEHDTAAQSILMTNDEAFAHAVEEAVERQLHTLARTETASASWRDFGAVILVKDFEDAIPLANRIAAEHLEIAVADAEAFVPRIRNAGSIFIGGYTPEVIGDYVGGCNHVLPTARSARFSSGLSVLDYMKRTSLLKLGSEQLRALGPAAIEIARAEGLDAHAQSVAIRLNL >biolip__4g09A The crystal structure of the c366s mutant of hdh from brucella suis in complex with a substituted benzyl ketone VTTLRQTDPDFEQKFAAFLSGEDVDRAVREIVDRVRREGDSALLDYSRRFDRIDLEKTGIAVTEAEIDAAFDAAPASTVEALKLARDRIEKHHARQLPKDDRYTDALGVELGSRWTAIEAVGLYVPGGTASYPSSVLMNAMPAKVAGVDRIVMVVPAPDGNLNPLVLVAARLAGVSEIYRVGGAQAIAALAYGTETIRPVAKIVGPGNAYVAAAKRIVFGTVGIDMIAGPSEVLIVADKDNNPDWIAADLLAQAEHDTAAQSILMTNDEAFAHAVEEAVERQLHTLARTETASASWRDFGAVILVKDFEDAIPLANRIAAEHLEIAVADAEAFVPRIRNAGSIFIGGYTPEVIGDYVGGSNHVLPTARSARFSSGLSVLDYMKRTSLLKLGSEQLRALGPAAIEIARAEGLDAHAQSVAIRLNLLEHHHHHH >ecocyc__HISTDEHYD-MONOMER histidinal/histidinol dehydrogenase (Escherichia coli K-12 substr. MG1655) MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKEQA >PDB_1kar_A L-histidinol dehydrogenase (hisd) structure complexed with histamine (inhibitor), zinc and NAD (cofactor) NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDE LKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIA DSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQY GPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSAL ASTIETLAAAERLTAHKNAVTLRVNALKEQA >PDB_1kah_A L-histidinol dehydrogenase (hisd) structure complexed with l-histidine (product), zn and NAD (cofactor) NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDE LKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIA DSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQY GPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSAL ASTIETLAAAERLTAHKNAVTLRVNALKEQA >SwissProt__P10370 Histidinol dehydrogenase; HDH; EC 1.1.1.23 (Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)) MSFNTLIDWNSCSPEQQRALLTRPAISASDSITRTVSDILDNVKTRGDDALREYSAKFDKTEVTALRVTPEEIAAAGARLSDELKQAMTAAVKNIETFHSAQTLPPVDVETQPGVRCQQVTRPVSSVGLYIPGGSAPLFSTVLMLATPARIAGCQKVVLCSPPPIADEILYAAQLCGVQEIFNVGGAQAIAALAFGSESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPDADIARKVAEAVERQLAELPRADTARQALSASRLIVTKDLAQCVAISNQYGPEHLIIQTRNARDLVDAITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKAGFSALASTIETLAAAERLTAHKNAVTLRVNALKEQA >SwissProt__P9WNW9 Histidinol dehydrogenase; HDH; EC 1.1.1.23 (Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)) MTAPPPVLTRIDLRGAELTAAELRAALPRGGADVEAVLPTVRPIVAAVAERGAEAALDFGASFDGVRPHAIRVPDAALDAALAGLDCDVCEALQVMVERTRAVHSGQRRTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQAAGVDSLVVASPPQAQWDGMPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDTDGAALTPVDMITGPGNIYVTAAKRLCRSRVGIDAEAGPTEIAILADHTADPVHVAADLISQAEHDELAASVLVTPSEDLADATDAELAGQLQTTVHRERVTAALTGRQSAIVLVDDVDAAVLVVNAYAAEHLEIQTADAPQVASRIRSAGAIFVGPWSPVSLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVEYTEAALKDVSGHVITLATAEDLPAHGEAVRRRFER >BRENDA__G7IKX3 histidinol dehydrogenase (EC 1.1.1.23) (Medicago truncatula) MKSALTTCNINWKCYQNHHRTSFSVTNTINYRTRCSISMANPIKTYHLSNLTQTELLSLKSRPRIDFSSVFDIVNPIVDDVHAHGDAAVKQYTSKFDKVDLENIVELVSDLPDPVLDPAIKEAFDVAYSNIYAFHAAQKSPEKSVENMKGVQCKRVARSINSVGLYVPGGTAVLPSTALMLAVPAQIAGCKTIVLANPPTRDGTTCKEVLYCAKKAGVTHLLKAGGAQAISAMAWGTETCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEVLVIADKHAIPSHVAADLLSQAEHGPDSQVVLVIAGDGVDQNAIQEEVSKQCQSLPRGEFAAKALSHSFIVHARDMLEAITFSNMYAPEHLIINVKDAEKWESFIENAGSVFLGSWTPESVGDYASGTNHVLPTYGYARMYSGVSLDSFLKYITVQSLTEEGLRKLGPYVETMAEVEGLEAHKRAVTLRLQDIEARQVSR >biolip__5vldF Crystal structure of medicago truncatula l-histidinol dehydrogenase in complex with l-histidine and NAD+ PIKTYHLSNLTQTELLSLKSRPRIDFSSVFDIVNPIVDDVHAHGDAAVKQYTSKFDKVDLENIVELVSDLPDPVLDPAIKEAFDVAYSNIYAFHAAQKSPEKSVENMKGVQCKRVARSINSVGLYVPGGTAVLPSTALMLAVPAQIAGCKTIVLANPPTRDGTTCKEVLYCAKKAGVTHLLKAGGAQAISAMAWGTETCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEVLVIADKHAIPSHVAADLLSQAEHGPDSQVVLVIAGDGVDQNAIQEEVSKQCQSLPRGEFAAKALSHSFIVHARDMLEAITFSNMYAPEHLIINVKDAEKWESFIENAGSVFLGSWTPESVGDYASGTNHVLPTYGYARMYSGVSLDSFLKYITVQSLTEEGLRKLGPYVETMAEVEGLEAHKRAVTLRLQDIEARQV >PDB_5vlb_A Crystal structure of medicago truncatula l-histidinol dehydrogenase in complex with imidazole IKTYHLSNLTQTELLSLKSRPRIDFSSVFDIVNPIVDDVHAHGDAAVKQYTSKFDKVDLENIVELVSDLPDPVLDPAIKE AFDVAYSNIYAFHAAQKSPEKSVENMKGVQCKRVARSINSVGLYVPGGTAVLPSTALMLAVPAQIAGCKTIVLANPPTRD GTTCKEVLYCAKKAGVTHLLKAGGAQAISAMAWGTETCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEVLVI ADKHAIPSHVAADLLSQAEHGPDSQVVLVIAGDGVDQNAIQEEVSKQCQSLPRGEFAAKALSHSFIVHARDMLEAITFSN MYAPEHLIINVKDAEKWESFIENAGSVFLGSWTPESVGDYASGTNHVLPTYGYARMYSGVSLDSFLKYITVQSLTEEGLR KLGPYVETMAEVEGLEAHKRAVTLRLQDIEARQV >PDB_5vlc_A Crystal structure of medicago truncatula l-histidinol dehydrogenase in complex with l-histidinol PIKTYHLSNLTQTELLSLKSRPRISVFDIVNPIVDDVHAHGDAAVKQYTSKFDKVDLENIVELVSDLPDPVLDPAIKEAF DVAYSNIYAFHAAQKSPEKSVENMKGVQCKRVARSINSVGLYVPGGTAVLPSTALMLAVPAQIAGCKTIVLANPPTRDGT TCKEVLYCAKKAGVTHLLKAGGAQAISAMAWGTETCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEVLVIAD KHAIPSHVAADLLSQAEHGPDSQVVLVIAGDGVDQNAIQEEVSKQCQSLPRGEFAAKALSHSFIVHARDMLEAITFSNMY APEHLIINVKDAEKWESFIENAGSVFLGSWTPESVGDYASGTNHVLPTYGYARMYSGVSLDSFLKYITVQSLTEEGLRKL GPYVETMAEVEGLEAHKRAVTLRLQDIEARQ >biolip__6an0A Crystal structure of histidinol dehydrogenase from elizabethkingia anophelis HHHHHMQTYINPPLSEWKNLIQRPVQKAEDLQNIVLTVFEDIKNEKDKALINYTKKFDKAYLTDIRVSSDEITAAIALVSDELIQAIQMAASNIEKFHASQKENKNIIETTEGVNCWREARPIENIGIYIPGGSAPLFSTVLMLGIPAQLAGCKNITLCTPPDESGNINPAILYTANLIGIKNIYKAGGIQAIGAMTFGTETIEKADKIFGPGNQYVTAAKQIAQNFGVAIDMPAGPSEVLVIADTTANPEFVAADLLSQAEHGADSQVILLTTDENILQQTLMQVENQLTQLPRKSIASQALLQSRGIVLDSIEKCIAFSNLYAPEHLILAIENTENYTDKITSAGSVFLGNFSCESAGDYASGTNHTLPTNGYARNYSGVSLDSFIKKITFQKVTKKGIQNIGPGIEKMAEAEELFAHKHAVSVRLKSLNS >BRENDA__A1BPP9 histidinol dehydrogenase (EC 1.1.1.23) (Geotrichum candidum) MTFPLLPAYASVAEFDNSLSLVGKAVFPYAADQLHNLIKFTQSTELQVNVQVESSVTEDQFEELIDNLLKLYNNGINEVILDLDLAERVVQRMIPGARVIYRTLVDKVASLPANASIAVPFSSPLGDLKSFNNGGSRTVYAFSETAKLVDVTPTVASGIIPIIDARQLTTEYELSEDVKKFPISEILLASLTTDRPDGLFTTLVADSSNYSLGLVYSSKKSIPEAIRTQTGVYQSRRHGLWYKGATSGATQKLLGIELDCDGDCLKFVVEQTGVGFCHLERTSCFGQSKGLRAMEATLWDRKSNAPEGSYTKRLFDDEVLLNAKIREEADELAEAKSKEDIAWECADLFYFALVRCAKYGVTLDEVERNLDMKSLKVTRRKGDAKPGYTKEQPKEESKPKEVPSEGRIELCKIDVSKASSQEIEDALRRPIQKTKQIMELVKPIVDNVRQNGDKALLELTAKFDGVALKTPVLEAPFPEELMQLPDNVKRAIDLSIDNVRKFHEAQLTETLQVETCPGVVCSRFARPIEKVGLYIPGGTAILPSTSLMLGVPAKVAGCKEIVFASPPKKDGTLTPEVIYVAHKVGAKCIVLAGGAQAVAAMAYGTETVPKCDKIFGPGNQFVTAAKMMVQNDTSALCSIDMPAGPSEVLVIADKYADPDFVASDLLSQAEHGIDSQVILLAVDMTDKELARIEDAVHNQAVQLPRVEIVRKCIAHSTTLSVATYEQALEMSNQYAPEHLILQIENASSYVDQVQHAGSVFVGAYSPESCGDYSSGTNHTLPTYGYARQYSGVNTATFQKFITSQDVTPEGLKHIGQAVMDLAAVEGLDAHRNAVKVRMEKLGLI >SwissProt__P00815 Histidine biosynthesis trifunctional protein; EC 3.5.4.19; EC 3.6.1.31; EC 1.1.1.23 (Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)) MVLPILPLIDDLASWNSKKEYVSLVGQVLLDGSSLSNEEILQFSKEEEVPLVALSLPSGKFSDDEIIAFLNNGVSSLFIASQDAKTAEHLVEQLNVPKERVVVEENGVFSNQFMVKQKFSQDKIVSIKKLSKDMLTKEVLGEVRTDRPDGLYTTLVVDQYERCLGLVYSSKKSIAKAIDLGRGVYYSRSRNEIWIKGETSGNGQKLLQISTDCDSDALKFIVEQENVGFCHLETMSCFGEFKHGLVGLESLLKQRLQDAPEESYTRRLFNDSALLDAKIKEEAEELTEAKGKKELSWEAADLFYFALAKLVANDVSLKDVENNLNMKHLKVTRRKGDAKPKFVGQPKAEEEKLTGPIHLDVVKASDKVGVQKALSRPIQKTSEIMHLVNPIIENVRDKGNSALLEYTEKFDGVKLSNPVLNAPFPEEYFEGLTEEMKEALDLSIENVRKFHAAQLPTETLEVETQPGVLCSRFPRPIEKVGLYIPGGTAILPSTALMLGVPAQVAQCKEIVFASPPRKSDGKVSPEVVYVAEKVGASKIVLAGGAQAVAAMAYGTETIPKVDKILGPGNQFVTAAKMYVQNDTQALCSIDMPAGPSEVLVIADEDADVDFVASDLLSQAEHGIDSQVILVGVNLSEKKIQEIQDAVHNQALQLPRVDIVRKCIAHSTIVLCDGYEEALEMSNQYAPEHLILQIANANDYVKLVDNAGSVFVGAYTPESCGDYSSGTNHTLPTYGYARQYSGANTATFQKFITAQNITPEGLENIGRAVMCVAKKEGLDGHRNAVKIRMSKLGLIPKDFQ >CharProtDB__CH_125862 histidinol dehydrogenase His2 (predicted); EC 1.1.1.23 (Schizosaccharomyces pombe) MPEYEIQVPSYRAAALTAEERTRLLARPIQNTQKIRTIVQPIIEDVKSRGEASLIDYASKFEKVQLKSAVLKAPFDDDLMKISPMIKEDIDIAFNNIFAFHSSQLRPTIAVQTMRGVVCQRMSRPINRVGLYIPGGTAVLPSTALMLGVPAKVAGCPHVVISTPVRKDGTVAPEIVYIANKIGAEAIILAGGAQAIAAMAYGISGVPKVNKIFGPGNQFVTAAKMHVQNDYGALVAIDLPAGPSEVLVIADETCNPESVALDLLSQAEHGLDSQIILLTVSLSPEMFDRIQKAINDHALRLSRSYIIKHAIKKSVIVQVDNVDQAFEWSNLYGPEHLVLHLKNASSYIPKIDNAGSVFVGPWSPVSMGDYASGTNHTLPTYGYASSYSGVSTDSFLKYITTQELTEEGIQRLGPTVIRLAELEGLTAHADAVRVRGVRL >CharProtDB__CH_123581 multifunctional enzyme that catalyzes three steps of histidine biosynthesis (Candida albicans) MIFPILPVISSPEDKQSIDEFSLVGQVLFPIESVSPKKHFIHQFPHDLDIFVNAIDNATTDQIVELLNVGIKQVFVNEKQYHDAIEAGLPSSRFVVAVDVPSTELLTSEASFVTSKPFSESDLKKYNANENRVIYIESNFTQDGAIELAKNYVPVIPSTKLTVKREEENKISISAVFVSTLTTDRPDGLYTTLITTPSPSYTALGIVYSSKDSIIAAIEEKVGVYQSRKRRDELWYKGKTSGATQKLVKLSKDCDSHVIQFMVEPRTGYGFCHRETKFTCFGDDIADSPARGLPKLDSTLQDRLENAPEVSYTKRLFDDEKLLIAKLKEELDELIEAKSKEEIAWECADLVYFAMVWCIKHGVRLADIEKNLDVKSLKVSRRKGDAKPQYQEAPVNSSYKLEIVSVDDAAAVERAMTRPVQKTADIMKLVLPIIEKVKSDGDKALIELTSKFDGVKLDAPVLQAPFPADLMDISEEMKAAIDLSMQNIEKFHAAQLPKEKVMTVETSPGVYCSRFAKPIENVGLYVPGGTAVLPSTAMMLGVPAKVAGCKNIIVASPPSRATGKLTPEVVYVAHKLGAKCIVMAGGAQAVTAMAYGTESVLKCDKILGPGNQFVTAAKMYVQNDTQALCSIDMPAGPSEVLVIADSNADADFVASDLLSQAEHGVDSQVILIGVGLSDEKLNEFQAAVERQAKVLPRKDIVAKCLAHSYILLAKTYKEAFDLSNQYAPEHLILQIDDAPSYVPDSIENAGSVFVGALSPESCGDYSSGTNHTLPTYGYARQYSGVNTATFQKFITSQEVTEKGLQNIGKAVMELARVEGLEAHRRAVEIRMERMAETK >metacyc__MONOMER-15897 sulfopropanediol 3-dehydrogenase monomer (EC 1.1.1.308) (Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197)) MISYLKKAEKTPQTETATAQKVVTEMLAEIQARGKDAVRQYAKQLDGWSGDIVLTPDQIREQTKDVPAGVRADIDFAIRQVTDFALAQRESLKEFSVELHPGVTAGQRVLPVNVVGCYAPAGRYAHIASAYMGVATAKAAGVKTVVACSSPFRGQGIHPHVLYAFQAAGADVIMALGGVQAIASMAYGLFTGKPADVVVGPGNKFVAEAKRSLYGQVGIDVFAGPSEVAVIADETADPAIVASDLVGQAEHGHESPAWLFTTSRDLADRVMALVPELIAKLPPTARDAATAAWRDYGEVILCGTREEVVEISDRYASEHLEVHTADLDWWLANLTCYGSLFLGEETTVAFGDKTSGPNHVLPTKGAARYSGGLSVHKFMKTLTWQQMTREATRQIGQVTARISRLEGMEAHARTADDRMAKYFPNASFEMGTPVEV >ENA__CAC03753.1 histidinol dehydrogenase, partial (Schwanniomyces occidentalis) IDLSMSNIEKFHAAQLPKEKVMTVETAPGVRCSRFAKPIENVGLYVPGGTAVLPSTAMMLGVPAKVAGCSNIIIASPPARATGKLTPEVVYVAHKLGAKCIVMAGGAQAITAMAYGTDSVLKCDKILGPGNQFVTAAKMYVQNDTQALCSIDMPAGPSEVLVIADGNADADFVASDLLSQAEHGIDSQVILIGVGLTKEKLTEFESAVKKQAEVLPRKEIVAKCLAHSYTLLVETYEQAFDLSNKYAPEHLILQIDNAQSYVPDYVENAGSVFVGSLSPESCGDYSSGTNHTLPTYGYARQYSGVNTATFQKFITSQDVSEEGLKSIGKAVMTLAAVEGLEAHRNAVHVRMEKLGLL