>Pf1N1B4_1066 Histidinol dehydrogenase (EC 1.1.1.23)
MTAPTAIRRLNAADPDFAHHLDHLLSWESVSDDSVNQRVLDIIKAVRERGDAALVEFTQKFDGLQVASMADLILPRERLELALTRITAPQREALEKAATRVRSYHEKQKQDSWSYTEADGTVLGQKVTPLDRAGLYVPGGKASYPSSVLMNAIPAKVAGVSEVVMVVPTPRGEINELVLAAACIAGVDRVFTIGGAQAVAALAYGTESVPKVDKVVGPGNIYVATAKRHVFGQVGIDMIAGPSEILVVCDGQTDPDWIAMDLFSQAEHDEDAQAILVSPDAEFLDKVAASIAKLLPTMERAEIIETSINGRGALIKVRDMEQAIEVANRIAPEHLELSVADPQAWLPQIRHAGAIFMGRHTSEALGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSIIFCSEQGASELGKTASVLARGESLTAHARSAEYRIVDDKKGN
>BRENDA__Q8G2R2 histidinol dehydrogenase (EC 1.1.1.23) (Brucella suis bv. 1)
MVTTLRQTDPDFEQKFAAFLSGKREVSEDVDRAVREIVDRVRREGDSALLDYSRRFDRIDLEKTGIAVTEAEIDAAFDAAPASTVEALKLARDRIEKHHARQLPKDDRYTDALGVELGSRWTAIEAVGLYVPGGTASYPSSVLMNAMPAKVAGVDRIVMVVPAPDGNLNPLVLVAARLAGVSEIYRVGGAQAIAALAYGTETIRPVAKIVGPGNAYVAAAKRIVFGTVGIDMIAGPSEVLIVADKDNNPDWIAADLLAQAEHDTAAQSILMTNDEAFAHAVEEAVERQLHTLARTETASASWRDFGAVILVKDFEDAIPLANRIAAEHLEIAVADAEAFVPRIRNAGSIFIGGYTPEVIGDYVGGCNHVLPTARSARFSSGLSVLDYMKRTSLLKLGSEQLRALGPAAIEIARAEGLDAHAQSVAIRLNL
>biolip__4g09A The crystal structure of the c366s mutant of hdh from brucella suis in complex with a substituted benzyl ketone
VTTLRQTDPDFEQKFAAFLSGEDVDRAVREIVDRVRREGDSALLDYSRRFDRIDLEKTGIAVTEAEIDAAFDAAPASTVEALKLARDRIEKHHARQLPKDDRYTDALGVELGSRWTAIEAVGLYVPGGTASYPSSVLMNAMPAKVAGVDRIVMVVPAPDGNLNPLVLVAARLAGVSEIYRVGGAQAIAALAYGTETIRPVAKIVGPGNAYVAAAKRIVFGTVGIDMIAGPSEVLIVADKDNNPDWIAADLLAQAEHDTAAQSILMTNDEAFAHAVEEAVERQLHTLARTETASASWRDFGAVILVKDFEDAIPLANRIAAEHLEIAVADAEAFVPRIRNAGSIFIGGYTPEVIGDYVGGSNHVLPTARSARFSSGLSVLDYMKRTSLLKLGSEQLRALGPAAIEIARAEGLDAHAQSVAIRLNLLEHHHHHH
>ecocyc__HISTDEHYD-MONOMER histidinal/histidinol dehydrogenase (Escherichia coli K-12 substr. MG1655)
MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKEQA
>PDB_1kar_A L-histidinol dehydrogenase (hisd) structure complexed with histamine (inhibitor), zinc and NAD (cofactor)
NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDE
LKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP
PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIA
DSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQY
GPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSAL
ASTIETLAAAERLTAHKNAVTLRVNALKEQA
>PDB_1kah_A L-histidinol dehydrogenase (hisd) structure complexed with l-histidine (product), zn and NAD (cofactor)
NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDE
LKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP
PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIA
DSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQY
GPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSAL
ASTIETLAAAERLTAHKNAVTLRVNALKEQA
>SwissProt__P10370 Histidinol dehydrogenase; HDH; EC 1.1.1.23 (Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720))
MSFNTLIDWNSCSPEQQRALLTRPAISASDSITRTVSDILDNVKTRGDDALREYSAKFDKTEVTALRVTPEEIAAAGARLSDELKQAMTAAVKNIETFHSAQTLPPVDVETQPGVRCQQVTRPVSSVGLYIPGGSAPLFSTVLMLATPARIAGCQKVVLCSPPPIADEILYAAQLCGVQEIFNVGGAQAIAALAFGSESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPDADIARKVAEAVERQLAELPRADTARQALSASRLIVTKDLAQCVAISNQYGPEHLIIQTRNARDLVDAITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKAGFSALASTIETLAAAERLTAHKNAVTLRVNALKEQA
>SwissProt__P9WNW9 Histidinol dehydrogenase; HDH; EC 1.1.1.23 (Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
MTAPPPVLTRIDLRGAELTAAELRAALPRGGADVEAVLPTVRPIVAAVAERGAEAALDFGASFDGVRPHAIRVPDAALDAALAGLDCDVCEALQVMVERTRAVHSGQRRTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQAAGVDSLVVASPPQAQWDGMPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDTDGAALTPVDMITGPGNIYVTAAKRLCRSRVGIDAEAGPTEIAILADHTADPVHVAADLISQAEHDELAASVLVTPSEDLADATDAELAGQLQTTVHRERVTAALTGRQSAIVLVDDVDAAVLVVNAYAAEHLEIQTADAPQVASRIRSAGAIFVGPWSPVSLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVEYTEAALKDVSGHVITLATAEDLPAHGEAVRRRFER
>BRENDA__A1BPP9 histidinol dehydrogenase (EC 1.1.1.23) (Geotrichum candidum)
MTFPLLPAYASVAEFDNSLSLVGKAVFPYAADQLHNLIKFTQSTELQVNVQVESSVTEDQFEELIDNLLKLYNNGINEVILDLDLAERVVQRMIPGARVIYRTLVDKVASLPANASIAVPFSSPLGDLKSFNNGGSRTVYAFSETAKLVDVTPTVASGIIPIIDARQLTTEYELSEDVKKFPISEILLASLTTDRPDGLFTTLVADSSNYSLGLVYSSKKSIPEAIRTQTGVYQSRRHGLWYKGATSGATQKLLGIELDCDGDCLKFVVEQTGVGFCHLERTSCFGQSKGLRAMEATLWDRKSNAPEGSYTKRLFDDEVLLNAKIREEADELAEAKSKEDIAWECADLFYFALVRCAKYGVTLDEVERNLDMKSLKVTRRKGDAKPGYTKEQPKEESKPKEVPSEGRIELCKIDVSKASSQEIEDALRRPIQKTKQIMELVKPIVDNVRQNGDKALLELTAKFDGVALKTPVLEAPFPEELMQLPDNVKRAIDLSIDNVRKFHEAQLTETLQVETCPGVVCSRFARPIEKVGLYIPGGTAILPSTSLMLGVPAKVAGCKEIVFASPPKKDGTLTPEVIYVAHKVGAKCIVLAGGAQAVAAMAYGTETVPKCDKIFGPGNQFVTAAKMMVQNDTSALCSIDMPAGPSEVLVIADKYADPDFVASDLLSQAEHGIDSQVILLAVDMTDKELARIEDAVHNQAVQLPRVEIVRKCIAHSTTLSVATYEQALEMSNQYAPEHLILQIENASSYVDQVQHAGSVFVGAYSPESCGDYSSGTNHTLPTYGYARQYSGVNTATFQKFITSQDVTPEGLKHIGQAVMDLAAVEGLDAHRNAVKVRMEKLGLI
>BRENDA__G7IKX3 histidinol dehydrogenase (EC 1.1.1.23) (Medicago truncatula)
MKSALTTCNINWKCYQNHHRTSFSVTNTINYRTRCSISMANPIKTYHLSNLTQTELLSLKSRPRIDFSSVFDIVNPIVDDVHAHGDAAVKQYTSKFDKVDLENIVELVSDLPDPVLDPAIKEAFDVAYSNIYAFHAAQKSPEKSVENMKGVQCKRVARSINSVGLYVPGGTAVLPSTALMLAVPAQIAGCKTIVLANPPTRDGTTCKEVLYCAKKAGVTHLLKAGGAQAISAMAWGTETCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEVLVIADKHAIPSHVAADLLSQAEHGPDSQVVLVIAGDGVDQNAIQEEVSKQCQSLPRGEFAAKALSHSFIVHARDMLEAITFSNMYAPEHLIINVKDAEKWESFIENAGSVFLGSWTPESVGDYASGTNHVLPTYGYARMYSGVSLDSFLKYITVQSLTEEGLRKLGPYVETMAEVEGLEAHKRAVTLRLQDIEARQVSR
>PDB_5vlc_A Crystal structure of medicago truncatula l-histidinol dehydrogenase in complex with l-histidinol
PIKTYHLSNLTQTELLSLKSRPRISVFDIVNPIVDDVHAHGDAAVKQYTSKFDKVDLENIVELVSDLPDPVLDPAIKEAF
DVAYSNIYAFHAAQKSPEKSVENMKGVQCKRVARSINSVGLYVPGGTAVLPSTALMLAVPAQIAGCKTIVLANPPTRDGT
TCKEVLYCAKKAGVTHLLKAGGAQAISAMAWGTETCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEVLVIAD
KHAIPSHVAADLLSQAEHGPDSQVVLVIAGDGVDQNAIQEEVSKQCQSLPRGEFAAKALSHSFIVHARDMLEAITFSNMY
APEHLIINVKDAEKWESFIENAGSVFLGSWTPESVGDYASGTNHVLPTYGYARMYSGVSLDSFLKYITVQSLTEEGLRKL
GPYVETMAEVEGLEAHKRAVTLRLQDIEARQ
>biolip__5vldF Crystal structure of medicago truncatula l-histidinol dehydrogenase in complex with l-histidine and NAD+
PIKTYHLSNLTQTELLSLKSRPRIDFSSVFDIVNPIVDDVHAHGDAAVKQYTSKFDKVDLENIVELVSDLPDPVLDPAIKEAFDVAYSNIYAFHAAQKSPEKSVENMKGVQCKRVARSINSVGLYVPGGTAVLPSTALMLAVPAQIAGCKTIVLANPPTRDGTTCKEVLYCAKKAGVTHLLKAGGAQAISAMAWGTETCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEVLVIADKHAIPSHVAADLLSQAEHGPDSQVVLVIAGDGVDQNAIQEEVSKQCQSLPRGEFAAKALSHSFIVHARDMLEAITFSNMYAPEHLIINVKDAEKWESFIENAGSVFLGSWTPESVGDYASGTNHVLPTYGYARMYSGVSLDSFLKYITVQSLTEEGLRKLGPYVETMAEVEGLEAHKRAVTLRLQDIEARQV
>PDB_5vlb_A Crystal structure of medicago truncatula l-histidinol dehydrogenase in complex with imidazole
IKTYHLSNLTQTELLSLKSRPRIDFSSVFDIVNPIVDDVHAHGDAAVKQYTSKFDKVDLENIVELVSDLPDPVLDPAIKE
AFDVAYSNIYAFHAAQKSPEKSVENMKGVQCKRVARSINSVGLYVPGGTAVLPSTALMLAVPAQIAGCKTIVLANPPTRD
GTTCKEVLYCAKKAGVTHLLKAGGAQAISAMAWGTETCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEVLVI
ADKHAIPSHVAADLLSQAEHGPDSQVVLVIAGDGVDQNAIQEEVSKQCQSLPRGEFAAKALSHSFIVHARDMLEAITFSN
MYAPEHLIINVKDAEKWESFIENAGSVFLGSWTPESVGDYASGTNHVLPTYGYARMYSGVSLDSFLKYITVQSLTEEGLR
KLGPYVETMAEVEGLEAHKRAVTLRLQDIEARQV
>SwissProt__P00815 Histidine biosynthesis trifunctional protein; EC 3.5.4.19; EC 3.6.1.31; EC 1.1.1.23 (Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast))
MVLPILPLIDDLASWNSKKEYVSLVGQVLLDGSSLSNEEILQFSKEEEVPLVALSLPSGKFSDDEIIAFLNNGVSSLFIASQDAKTAEHLVEQLNVPKERVVVEENGVFSNQFMVKQKFSQDKIVSIKKLSKDMLTKEVLGEVRTDRPDGLYTTLVVDQYERCLGLVYSSKKSIAKAIDLGRGVYYSRSRNEIWIKGETSGNGQKLLQISTDCDSDALKFIVEQENVGFCHLETMSCFGEFKHGLVGLESLLKQRLQDAPEESYTRRLFNDSALLDAKIKEEAEELTEAKGKKELSWEAADLFYFALAKLVANDVSLKDVENNLNMKHLKVTRRKGDAKPKFVGQPKAEEEKLTGPIHLDVVKASDKVGVQKALSRPIQKTSEIMHLVNPIIENVRDKGNSALLEYTEKFDGVKLSNPVLNAPFPEEYFEGLTEEMKEALDLSIENVRKFHAAQLPTETLEVETQPGVLCSRFPRPIEKVGLYIPGGTAILPSTALMLGVPAQVAQCKEIVFASPPRKSDGKVSPEVVYVAEKVGASKIVLAGGAQAVAAMAYGTETIPKVDKILGPGNQFVTAAKMYVQNDTQALCSIDMPAGPSEVLVIADEDADVDFVASDLLSQAEHGIDSQVILVGVNLSEKKIQEIQDAVHNQALQLPRVDIVRKCIAHSTIVLCDGYEEALEMSNQYAPEHLILQIANANDYVKLVDNAGSVFVGAYTPESCGDYSSGTNHTLPTYGYARQYSGANTATFQKFITAQNITPEGLENIGRAVMCVAKKEGLDGHRNAVKIRMSKLGLIPKDFQ
>biolip__6an0A Crystal structure of histidinol dehydrogenase from elizabethkingia anophelis
HHHHHMQTYINPPLSEWKNLIQRPVQKAEDLQNIVLTVFEDIKNEKDKALINYTKKFDKAYLTDIRVSSDEITAAIALVSDELIQAIQMAASNIEKFHASQKENKNIIETTEGVNCWREARPIENIGIYIPGGSAPLFSTVLMLGIPAQLAGCKNITLCTPPDESGNINPAILYTANLIGIKNIYKAGGIQAIGAMTFGTETIEKADKIFGPGNQYVTAAKQIAQNFGVAIDMPAGPSEVLVIADTTANPEFVAADLLSQAEHGADSQVILLTTDENILQQTLMQVENQLTQLPRKSIASQALLQSRGIVLDSIEKCIAFSNLYAPEHLILAIENTENYTDKITSAGSVFLGNFSCESAGDYASGTNHTLPTNGYARNYSGVSLDSFIKKITFQKVTKKGIQNIGPGIEKMAEAEELFAHKHAVSVRLKSLNS
>CharProtDB__CH_125862 histidinol dehydrogenase His2 (predicted); EC 1.1.1.23 (Schizosaccharomyces pombe)
MPEYEIQVPSYRAAALTAEERTRLLARPIQNTQKIRTIVQPIIEDVKSRGEASLIDYASKFEKVQLKSAVLKAPFDDDLMKISPMIKEDIDIAFNNIFAFHSSQLRPTIAVQTMRGVVCQRMSRPINRVGLYIPGGTAVLPSTALMLGVPAKVAGCPHVVISTPVRKDGTVAPEIVYIANKIGAEAIILAGGAQAIAAMAYGISGVPKVNKIFGPGNQFVTAAKMHVQNDYGALVAIDLPAGPSEVLVIADETCNPESVALDLLSQAEHGLDSQIILLTVSLSPEMFDRIQKAINDHALRLSRSYIIKHAIKKSVIVQVDNVDQAFEWSNLYGPEHLVLHLKNASSYIPKIDNAGSVFVGPWSPVSMGDYASGTNHTLPTYGYASSYSGVSTDSFLKYITTQELTEEGIQRLGPTVIRLAELEGLTAHADAVRVRGVRL
>CharProtDB__CH_123581 multifunctional enzyme that catalyzes three steps of histidine biosynthesis (Candida albicans)
MIFPILPVISSPEDKQSIDEFSLVGQVLFPIESVSPKKHFIHQFPHDLDIFVNAIDNATTDQIVELLNVGIKQVFVNEKQYHDAIEAGLPSSRFVVAVDVPSTELLTSEASFVTSKPFSESDLKKYNANENRVIYIESNFTQDGAIELAKNYVPVIPSTKLTVKREEENKISISAVFVSTLTTDRPDGLYTTLITTPSPSYTALGIVYSSKDSIIAAIEEKVGVYQSRKRRDELWYKGKTSGATQKLVKLSKDCDSHVIQFMVEPRTGYGFCHRETKFTCFGDDIADSPARGLPKLDSTLQDRLENAPEVSYTKRLFDDEKLLIAKLKEELDELIEAKSKEEIAWECADLVYFAMVWCIKHGVRLADIEKNLDVKSLKVSRRKGDAKPQYQEAPVNSSYKLEIVSVDDAAAVERAMTRPVQKTADIMKLVLPIIEKVKSDGDKALIELTSKFDGVKLDAPVLQAPFPADLMDISEEMKAAIDLSMQNIEKFHAAQLPKEKVMTVETSPGVYCSRFAKPIENVGLYVPGGTAVLPSTAMMLGVPAKVAGCKNIIVASPPSRATGKLTPEVVYVAHKLGAKCIVMAGGAQAVTAMAYGTESVLKCDKILGPGNQFVTAAKMYVQNDTQALCSIDMPAGPSEVLVIADSNADADFVASDLLSQAEHGVDSQVILIGVGLSDEKLNEFQAAVERQAKVLPRKDIVAKCLAHSYILLAKTYKEAFDLSNQYAPEHLILQIDDAPSYVPDSIENAGSVFVGALSPESCGDYSSGTNHTLPTYGYARQYSGVNTATFQKFITSQEVTEKGLQNIGKAVMELARVEGLEAHRRAVEIRMERMAETK
>metacyc__MONOMER-15897 sulfopropanediol 3-dehydrogenase monomer (EC 1.1.1.308) (Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197))
MISYLKKAEKTPQTETATAQKVVTEMLAEIQARGKDAVRQYAKQLDGWSGDIVLTPDQIREQTKDVPAGVRADIDFAIRQVTDFALAQRESLKEFSVELHPGVTAGQRVLPVNVVGCYAPAGRYAHIASAYMGVATAKAAGVKTVVACSSPFRGQGIHPHVLYAFQAAGADVIMALGGVQAIASMAYGLFTGKPADVVVGPGNKFVAEAKRSLYGQVGIDVFAGPSEVAVIADETADPAIVASDLVGQAEHGHESPAWLFTTSRDLADRVMALVPELIAKLPPTARDAATAAWRDYGEVILCGTREEVVEISDRYASEHLEVHTADLDWWLANLTCYGSLFLGEETTVAFGDKTSGPNHVLPTKGAARYSGGLSVHKFMKTLTWQQMTREATRQIGQVTARISRLEGMEAHARTADDRMAKYFPNASFEMGTPVEV
>ENA__CAC03753.1 histidinol dehydrogenase, partial (Schwanniomyces occidentalis)
IDLSMSNIEKFHAAQLPKEKVMTVETAPGVRCSRFAKPIENVGLYVPGGTAVLPSTAMMLGVPAKVAGCSNIIIASPPARATGKLTPEVVYVAHKLGAKCIVMAGGAQAITAMAYGTDSVLKCDKILGPGNQFVTAAKMYVQNDTQALCSIDMPAGPSEVLVIADGNADADFVASDLLSQAEHGIDSQVILIGVGLTKEKLTEFESAVKKQAEVLPRKEIVAKCLAHSYTLLVETYEQAFDLSNKYAPEHLILQIDNAQSYVPDYVENAGSVFVGSLSPESCGDYSSGTNHTLPTYGYARQYSGVNTATFQKFITSQDVSEEGLKSIGKAVMTLAAVEGLEAHRNAVHVRMEKLGLL