Family Search for PF05018 (CFA20_dom)

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PF05018 hits 25 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

CFA20_BOVIN / Q6B857 Cilia- and flagella-associated protein 20 from Bos taurus (Bovine) (see 2 papers)
CFA20_MOUSE / Q8BTU1 Cilia- and flagella-associated protein 20; Gene trap locus 3 protein from Mus musculus (Mouse) (see 2 papers)
Aligns to 1:185 / 193 (95.9%), covers 99.5% of PF05018, 320.0 bits

• function: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility (PubMed:34715025). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity).
• function: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation.

CFA20_DANRE / Q6PBJ2 Cilia- and flagella-associated protein 20 from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
Aligns to 1:185 / 192 (96.4%), covers 99.5% of PF05018, 319.0 bits

• function: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). Plays a role in cilia stability (PubMed:24574454).
  disruption phenotype: Display curved body axis, short somite length and defective heart-looping orientation.

CFA20_HUMAN / Q9Y6A4 Cilia- and flagella-associated protein 20; Basal body up-regulated protein 22; Transcription factor IIB from Homo sapiens (Human) (see 2 papers)
Aligns to 1:185 / 193 (95.9%), covers 99.5% of PF05018, 318.5 bits

• function: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility (PubMed:24414207). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). Involved in the regulation of the size and morphology of cilia (PubMed:24414207). Required for axonemal microtubules polyglutamylation (PubMed:24414207).

CFA20_DROME / Q9VKV8 Cilia- and flagella-associated protein 20; Basal body up-regulated protein 22 from Drosophila melanogaster (Fruit fly) (see paper)
Aligns to 1:185 / 199 (93.0%), covers 99.5% of PF05018, 317.8 bits

• function: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility (PubMed:24414207). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). Involved in the regulation of the size and morphology of cilia. Required for sperm individualization, differentiation of the sperm flagellum and tubulin polyglycylation of axonemal microtubules.
  disruption phenotype: Flies are viable and develop until late pupal stages. Display defects in wing posture and inflation, in locomotion and climbing activities and have a reduced lifespan. Males produce immotile sperm and show defects in sperm individualization process within cysts. Display defects of polyglycylation incorporation in sperm axonemal microtubules.

CFA20_PARTE / A0CDD4 Cilia- and flagella-associated protein 20; Bug22p from Paramecium tetraurelia (see paper)
Aligns to 1:185 / 191 (96.9%), covers 99.5% of PF05018, 313.6 bits

• function: Cilium- and flagellum-specific protein required for axonemal structure organization and motility (PubMed:20118210). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). May also play a role in cortical organization of basal body.

CFA20_CHLRE / A8IU92 Cilia- and flagella-associated protein 20; Basal body up-regulated protein 22; Bug22p; Flagellar-associated protein 20 from Chlamydomonas reinhardtii (Chlamydomonas smithii) (see 3 papers)
Aligns to 1:185 / 190 (97.4%), covers 99.5% of PF05018, 313.1 bits

• function: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility (PubMed:24259666, PubMed:24574454). Involved in the control of flagellar beating in an asymmetric and planar waveform (PubMed:24259666, PubMed:24574454). Stabilizes outer doublet microtubules (DMTs) of the axoneme and may work as a scaffold for intratubular proteins, such as tektin and PACRG, to produce the beak structures in DMT1, 5 and 6 (PubMed:24259666, PubMed:24574454). Not essential for flagellar assembly (PubMed:24574454).
  disruption phenotype: Exhibit erratic movements with cells continuously turning around the body axis. Display longer and sharp kinks flagella. Flagella beat in a uncoordinated and deformed non-planar manner. Lost beak-like strucure projections in B-tubules of the outer doublet microtubules (DMTs) 1, 5 and 6.

POC16_CHLRE / A8JAN3 Centriole proteome protein 16 from Chlamydomonas reinhardtii (Chlamydomonas smithii) (see paper)
Aligns to 2:187 / 2083 (8.9%), covers 97.8% of PF05018, 155.6 bits

• function: Required for flagellum assembly and/or maintenance.
  disruption phenotype: Mutants display shorter flagella and cannot swim.

WDR90_HUMAN / Q96KV7 WD repeat-containing protein 90 from Homo sapiens (Human) (see paper)
Aligns to 1:189 / 1748 (10.8%), covers 92.4% of PF05018, 117.5 bits

• function: Required for efficient primary cilium formation.

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