Family Search for PF05303 (GSKIP_dom)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF05303 hits 17 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

GSKIP_RAT / Q5PPI3 GSK3B-interacting protein; GSKIP from Rattus norvegicus (Rat) (see paper)
Aligns to 33:133 / 139 (72.7%), covers 100.0% of PF05303, 120.1 bits

• function: A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron proliferation; while increases beta- catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (By similarity). May play a role in cleft palate formation and is required for postnatal life through modulation of the activity of GSK3B during development (By similarity).
  subunit: Forms a complex composed of PRKAR2A or PRKAR2B, GSK3B and GSKIP through GSKIP interaction; facilitates PKA-induced phosphorylation of GSK3B leading to GSK3B inactivation; recruits DNM1L through GSK3B for PKA-mediated phosphorylation of DNM1L; promotes beta- catenin degradation through GSK3B-induced phosphorylation of beta- catenin; stabilizes beta-catenin and enhances Wnt-induced signaling through PKA-induced phosphorylation of beta-catenin (PubMed:20007971). Interacts with GSK3B; induces GSK3B-mediated phosphorylation of GSKIP and inhibits GSK3B kinase activity (By similarity).

GSKIP_MOUSE / Q8BGR8 GSK3B-interacting protein; GSKIP from Mus musculus (Mouse) (see paper)
Aligns to 33:133 / 139 (72.7%), covers 100.0% of PF05303, 119.5 bits

• function: A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron proliferation; while increases beta- catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (By similarity). May play a role in cleft palate formation and is required for postnatal life through modulation of the activity of GSK3B during development (PubMed:26582204).
  subunit: Forms a complex composed of PRKAR2A or PRKAR2B, GSK3B and GSKIP through GSKIP interaction; facilitates PKA-induced phosphorylation of GSK3B leading to GSK3B inactivation; recruits DNM1L through GSK3B for PKA-mediated phosphorylation of DNM1L; promotes beta- catenin degradation through GSK3B-induced phosphorylation of beta- catenin; stabilizes beta-catenin and enhances Wnt-induced signaling through PKA-induced phosphorylation of beta-catenin. Interacts with GSK3B; induces GSK3B-mediated phosphorylation of GSKIP and inhibits GSK3B kinase activity.
  disruption phenotype: Knockout Gskip mice die at birth. At 18.5 dpc, embryos are still alive but rapidly die within 5 to 30 min after casarean section. Embryos obtained at 18.5 dpc are cyanotic, suffer from respiratory distress, and fail to initiate breathing properly.

GSKIP_HUMAN / Q9P0R6 GSK3B-interacting protein; GSKIP; GSK3beta interaction protein from Homo sapiens (Human) (see 5 papers)
Aligns to 33:133 / 139 (72.7%), covers 100.0% of PF05303, 117.6 bits

• function: A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets (PubMed:27484798, PubMed:25920809, PubMed:16981698). The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively (PubMed:27484798, PubMed:16981698). Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B (PubMed:25920809). During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (PubMed:19830702).
  subunit: Forms a complex composed of PRKAR2A or PRKAR2B, GSK3B and GSKIP through GSKIP interaction; facilitates PKA-induced phosphorylation of GSK3B leading to GSK3B inactivation; recruits DNM1L through GSK3B for PKA-mediated phosphorylation of DNM1L; promotes beta- catenin degradation through GSK3B-induced phosphorylation of beta- catenin; stabilizes beta-catenin and enhances Wnt-induced signaling through PKA-induced phosphorylation of beta-catenin (PubMed:20007971, PubMed:25920809, PubMed:27484798). Interacts with GSK3B; induces GSK3B- mediated phosphorylation of GSKIP and inhibits GSK3B kinase activity (PubMed:16981698, PubMed:25920809).

CLU_DROME / A1ZAB5 Protein clueless; Clustered mitochondria protein homolog from Drosophila melanogaster (Fruit fly) (see paper)
Aligns to 319:395 / 1448 (5.3%), covers 63.8% of PF05303, 26.8 bits

• function: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.
  disruption phenotype: Causes mitochondria to cluster within cells.

CLU_DICDI / O15818 Clustered mitochondria protein homolog from Dictyostelium discoideum (Social amoeba) (see paper)
Aligns to 283:356 / 1320 (5.6%), covers 66.7% of PF05303, 26.2 bits

• function: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.
  disruption phenotype: Causes mitochondria to cluster within cells.

CLU_ARATH / F4J5S1 Clustered mitochondria protein; Friendly mitochondria protein from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Aligns to 258:362 / 1407 (7.5%), covers 69.5% of PF05303, 24.1 bits

• function: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria (By similarity) (PubMed:14617080). Together with REC2, REC3 and FMT/CLU, contributes to the establishment of the cellular volume devoted to the chloroplast compartment (PubMed:26862170).
  disruption phenotype: Causes mitochondria to cluster within cells (PubMed:14617080). Reduced proportion of the cellular volume devoted to chloroplasts leading to an abnormal chloroplasts distributions (PubMed:26862170). Lower levels of chlorophyll, especially in plants lacking REC1, REC2, REC3 and FMT/CLU (PubMed:26862170).

Or search for genetic data about PF05303 in the Fitness Browser