Family Search for PF06736 (TMEM175)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
PF06736 hits 18 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.
TM175_HUMAN / Q9BSA9 Endosomal/lysosomal proton channel TMEM175; Potassium channel TMEM175; Transmembrane protein 175; hTMEM175 from Homo sapiens (Human) (see 12 papers)
2 alignments in 35:356 / 504 (37.1%), covering up to 100.0% of PF06736, 149.2 bits
- function: Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH (PubMed:35750034, PubMed:35333573, PubMed:37390818). Activated at low pH (under pH 4.6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis (PubMed:35750034). Regulation of lumenal pH stability is required for autophagosome-lysosome fusion (PubMed:26317472, PubMed:32267231). Also acts as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes (PubMed:26317472, PubMed:28723891, PubMed:32228865, PubMed:32267231, PubMed:33505021). Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors (PubMed:33505021). The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation (PubMed:33505021). The lysoK(GF) complex is required to protect neurons against stress-induced damage (PubMed:33505021).
catalytic activity: H(+)(in) = H(+)(out) (RHEA:34979)
catalytic activity: K(+)(in) = K(+)(out) (RHEA:29463)
subunit: Homodimer (PubMed:28723891, PubMed:32228865, PubMed:35608336). Interacts with AKT (AKT1, AKT2 or AKT3); leading to formation of the lysoK(GF) complex, which activates the channel (PubMed:33505021). Interacts with LAMP1; inhibiting the proton channel activity of TMEM175 (PubMed:37390818). Interacts with LAMP2; inhibiting the proton channel activity of TMEM175 (PubMed:37390818).
TM175_RAT / Q6AY05 Endosomal/lysosomal proton channel TMEM175; Potassium channel TMEM175; Transmembrane protein 175 from Rattus norvegicus (Rat) (see paper)
2 alignments in 32:353 / 499 (37.5%), covering up to 100.0% of PF06736, 144.8 bits
- function: Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH (By similarity). Activated at low pH (under pH 4.6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis (By similarity). Regulation of lumenal pH stability is required for autophagosome-lysosome fusion (By similarity). Also acts as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes (By similarity). Constitutes the pore- forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors (By similarity). The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation (By similarity). The lysoK(GF) complex is required to protect neurons against stress-induced damage (PubMed:32799888) (Probable).
catalytic activity: H(+)(in) = H(+)(out) (RHEA:34979)
catalytic activity: K(+)(in) = K(+)(out) (RHEA:29463)
subunit: Homodimer. Interacts with AKT (AKT1, AKT2 or AKT3); leading to formation of the lysoK(GF) complex, which activates the channel. Interacts with LAMP1; inhibiting the proton channel activity of TMEM175. Interacts with LAMP2; inhibiting the proton channel activity of TMEM175.
TM175_MOUSE / Q9CXY1 Endosomal/lysosomal proton channel TMEM175; Potassium channel TMEM175; Transmembrane protein 175; mTMEM175 from Mus musculus (Mouse) (see 3 papers)
2 alignments in 32:353 / 499 (37.5%), covering up to 100.0% of PF06736, 144.5 bits
- function: Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH (PubMed:35750034). Activated at low pH (under pH 4.6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis (By similarity). Regulation of lumenal pH stability is required for autophagosome-lysosome fusion (PubMed:26317472). Also acts as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes (PubMed:26317472, PubMed:33505021). Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors (PubMed:33505021). The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation (PubMed:33505021). The lysoK(GF) complex is required to protect neurons against stress-induced damage (PubMed:33505021).
catalytic activity: H(+)(in) = H(+)(out) (RHEA:34979)
catalytic activity: K(+)(in) = K(+)(out) (RHEA:29463)
subunit: Homodimer (By similarity). Interacts with AKT (AKT1, AKT2 or AKT3); leading to formation of the lysoK(GF) complex, which activates the channel (PubMed:33505021). Interacts with LAMP1; inhibiting the proton channel activity of TMEM175 (By similarity). Interacts with LAMP2; inhibiting the proton channel activity of TMEM175 (By similarity).
disruption phenotype: Mice display accelerated loss of dopaminergic neurons and impaired motor skills (PubMed:33505021). Knockout neurons show increased damage in response to insults and an accumulation of alpha-synuclein (PubMed:33505021, PubMed:35750034). The accumulation of alpha-synuclein leads to increased damage to the integrity of lysosomal membranes (PubMed:33505021, PubMed:35750034).
TM175_CHRP1 / A0A086F3E3 Potassium channel HX13_20290 from Chryseobacterium sp. (strain P1-3) (see paper)
Aligns to 5:89 / 192 (44.3%), covers 100.0% of PF06736, 119.8 bits
- function: Potassium channel.
catalytic activity: K(+)(in) = K(+)(out) (RHEA:29463)
subunit: Homotetramer (PubMed:28723891).
TM175_STRC3 / S5VBU1 Potassium channel B446_29190 from Streptomyces collinus (strain DSM 40733 / Tue 365) (see paper)
Aligns to 6:94 / 206 (43.2%), covers 100.0% of PF06736, 113.3 bits
- function: Potassium channel.
catalytic activity: K(+)(in) = K(+)(out) (RHEA:29463)
subunit: Homotetramer (PubMed:28723891).
TM175_CHAP6 / K9UJK2 Potassium channel Cha6605_3372; Transmembrane protein 175; CmTMEM175 from Chamaesiphon minutus (strain ATCC 27169 / PCC 6605) (see paper)
Aligns to 12:102 / 203 (44.8%), covers 100.0% of PF06736, 99.1 bits
- function: Potassium channel (PubMed:28723891). The channel is permeable for K(+), Rb(+) and Cs(+), while it is unable to conduct Na(+) (PubMed:28723891).
catalytic activity: K(+)(in) = K(+)(out) (RHEA:29463)
subunit: Homotetramer (PubMed:28723891).
TM175_MARTH / E4TN31 Potassium channel Ftrac_2467; Transmembrane protein 175; MtTMEM175 from Marivirga tractuosa (strain ATCC 23168 / DSM 4126 / NBRC 15989 / NCIMB 1408 / VKM B-1430 / H-43) (Microscilla tractuosa) (Flexibacter tractuosus) (see paper)
Aligns to 24:105 / 247 (33.2%), covers 96.6% of PF06736, 50.7 bits
- function: Potassium channel; forms a potassium-permeable leak-like channel with weak selectivity for potassium (PubMed:32267231). The channel is permeable for K(+), Rb(+) and Cs(+) (PubMed:32267231).
catalytic activity: K(+)(in) = K(+)(out) (RHEA:29463)
subunit: Homotetramer.
Or search for genetic data about PF06736 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory