Family Search for PF07773 (TCTN_DUF1619)

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PF07773 hits 11 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

TECT1_HUMAN / Q2MV58 Tectonic-1 from Homo sapiens (Human) (see paper)
Aligns to 78:387 / 587 (52.8%), covers 100.0% of PF07773, 319.5 bits

• function: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23 (By similarity).
  subunit: Part of the tectonic-like complex (also named B9 complex).

TECT1_MOUSE / Q8BZ64 Tectonic-1 from Mus musculus (Mouse) (see 3 papers)
Aligns to 82:395 / 593 (53.0%), covers 100.0% of PF07773, 319.5 bits

• function: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23.
  subunit: Part of the tectonic-like complex (also named B9 complex).
  disruption phenotype: Null animals show disruption of nodal flow, laterality defects, and neural tube dorsalization. Basal bodies dock to the cellular plasma membrane, but fail to extend axonemes. However, cilia are present in the notochord, early gut epithelium, and mesenchymal cells surrounding the neural tube and in the limb bud. Null embryos develop an extra preaxial digit on 1 or both hindlimbs. Although sonic hedgehog (Shh) expression is normal, downstream signaling is disturbed, suggesting that Tctn1 is required for cilium- dependent Shh signal transduction.

TECT3_HUMAN / Q6NUS6 Tectonic-3 from Homo sapiens (Human) (see 2 papers)
Aligns to 90:390 / 607 (49.6%), covers 100.0% of PF07773, 297.0 bits

• function: Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). May be involved in apoptosis regulation. Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway.
  subunit: Part of the tectonic-like complex (also named B9 complex).

TECT3_MOUSE / Q8R2Q6 Tectonic-3 from Mus musculus (Mouse) (see paper)
Aligns to 78:379 / 595 (50.8%), covers 100.0% of PF07773, 287.5 bits

• function: Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. May be involved in apoptosis regulation (By similarity). Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway.
  subunit: Part of the tectonic-like complex (also named B9 complex).

TECT2_HUMAN / Q96GX1 Tectonic-2 from Homo sapiens (Human) (see 3 papers)
Aligns to 171:444 / 697 (39.3%), covers 100.0% of PF07773, 242.5 bits

• function: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction (By similarity).
  subunit: Part of the tectonic-like complex (also named B9 complex).

TECT2_MOUSE / Q2MV57 Tectonic-2 from Mus musculus (Mouse) (see 4 papers)
Aligns to 171:442 / 700 (38.9%), covers 100.0% of PF07773, 239.7 bits

• function: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction.
  subunit: Part of the tectonic-like complex (also named B9 complex).
  disruption phenotype: Mice have ventricular septal defects and can display right-sided stomach. The embryos exhibit microphthalmia, cleft palate and polydactyly. Embryos lack also nodal cilia. Cilia in neural tubes are scarce and morphologically defective, and failed to elongate axonemes. Basal bodies dock to the plasma membrane in Tctn2 null neural epithelium. No Arl13b ciliary staining in defective Tctn2 embryos perineural mesenchyme suggesting that, as in Tctn1 null mutants, defective Tctn2 cilia lack Arl13b. Tctn1 and Tctn2 share a common function, with both affecting ciliogenesis in a tissue-specific manner.

TECT_DROME / Q9VMH0 Tectonic; dTectonic from Drosophila melanogaster (Fruit fly) (see paper)
Aligns to 117:403 / 657 (43.7%), covers 100.0% of PF07773, 193.0 bits

• function: Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (PubMed:27646273). Has a role in ciliary structure and function (PubMed:27646273).
  subunit: Probable component of the tectonic-like complex (also named MKS complex), composed of B9d1, B9d2, Cc2d2a, Mks1 and tctn.
  disruption phenotype: Simultaneous knockout of B9d2 and tctn is viable and does not show sensory behavioral defects (PubMed:27646273). Males produce motile sperm and show only slightly reduced fertility (PubMed:27646273). Sperm flagella show weak ultrastructural defects including broken and disorganised structure (PubMed:27646273). Length of the transition zone is decreased and recruitment of the tectonic- like complex compromised (PubMed:27646273).

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