Family Search for PF12141 (BMT)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF12141 hits 18 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

BMT2_CANAL / Q59MA6 Beta-mannosyltransferase 2; Repressed during hyphae development protein 1; WRY family protein 7; EC 2.4.1.- from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 4 papers)
Aligns to 147:626 / 654 (73.4%), covers 100.0% of PF12141, 650.1 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis. Required for the addition of beta-mannose to the acid-labile fraction of cell wall phosphopeptidomannan.
  disruption phenotype: Impairs the elongation of beta-mannose chains on the acid-labile fraction of cell wall phosphopeptidomannan.

BMT8_CANAL / Q5AHD6 Beta-mannosyltransferase 8; WRY family protein 3; EC 2.4.1.- from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 2 papers)
Aligns to 117:642 / 694 (75.8%), covers 100.0% of PF12141, 625.4 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis through beta-1,2-mannosylation of cell wall phosphopeptidomannan (By similarity). Plays a role in the ability to produce hyphae in the presence of three bacterial species.
  disruption phenotype: Leads to a hypo-filamentous phenotype.

BMT1_CANAL / Q5ADQ9 Beta-mannosyltransferase 1; WRY family protein 4; EC 2.4.1.- from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 2 papers)
Aligns to 176:676 / 684 (73.2%), covers 100.0% of PF12141, 618.9 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis. Required for addition of the first beta-mannose residue to acid-stable fraction of cell wall phosphopeptidomannan. Plays a key role in reducing host inflammatory response.
  disruption phenotype: Impairs the mannosylation of beta-mannose chains on the acid-stable fraction of cell wall phosphopeptidomannan.

BMT5_CANAL / Q5ALW2 Beta-mannosyltransferase 5; WRY family protein 6; EC 2.4.1.- from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 2 papers)
Aligns to 120:595 / 612 (77.8%), covers 98.6% of PF12141, 618.9 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis. Required for beta-1,2-mannose transfer on phospholipomannan.

BMT4_CANAL / Q5ABT8 Beta-mannosyltransferase 4; WRY family protein 1; EC 2.4.1.- from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 3 papers)
Aligns to 139:630 / 781 (63.0%), covers 100.0% of PF12141, 594.1 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis. Required for the elongation of beta-mannose chains on the acid-labile fraction of cell wall phosphopeptidomannan.
  disruption phenotype: Impairs the elongation of beta-mannose chains on the acid-labile fraction of cell wall phosphopeptidomannan.

BMT6_CANAL / Q5ABU8 Beta-mannosyltransferase 6; WRY family protein 2; EC 2.4.1.- from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 3 papers)
Aligns to 146:624 / 646 (74.1%), covers 100.0% of PF12141, 593.9 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis. Required for beta-1,2-mannose transfer on phospholipomannan. Required for pro-inflammatory response in macrophages through phospholipomannan- induced TNF-alpha production.
  disruption phenotype: Leads to the production of phospholipomannan with short truncated oligomannosidic chain and impairs induction of TNF- alpha production in macrophages.

BMT9_CANAL / Q5AMH3 Beta-mannosyltransferase 9; WRY family protein 5; EC 2.4.1.- from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 2 papers)
Aligns to 167:755 / 782 (75.3%), covers 100.0% of PF12141, 547.6 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis through beta-1,2-mannosylation of cell wall phosphopeptidomannan.

BMT7_CANAL / Q5AEC6 Beta-mannosyltransferase 7; WRY family protein 8; EC 2.4.1.- from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 2 papers)
2 alignments in 131:632 / 651 (77.1%), covering up to 51.0% of PF12141, 438.3 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis through beta-1,2-mannosylation of cell wall phosphopeptidomannan.

BMT1_KOMPG / C4R7X9 Beta-mannosyltransferase 1; EC 2.4.1.- from Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris) (see 2 papers)
2 alignments in 85:524 / 652 (67.5%), covering up to 51.0% of PF12141, 316.3 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis. Involved in the beta-mannosylation of outer chains of N-glycans.
  disruption phenotype: Impaired expression of beta-mannose epitopes and decreases alpha-mannosidase resistant glycans.

BMT3_KOMPG / C4QZ06 Beta-mannosyltransferase 3; EC 2.4.1.- from Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris) (see 2 papers)
2 alignments in 75:506 / 594 (72.7%), covering up to 50.6% of PF12141, 283.6 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis.
  disruption phenotype: Decreases alpha-mannosidase resistant glycans.

BMT2_KOMPG / C4R7X8 Beta-mannosyltransferase 2; EC 2.4.1.- from Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris) (see 2 papers)
2 alignments in 74:505 / 644 (67.1%), covering up to 50.0% of PF12141, 278.3 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis. Initiates the beta-mannosylation of core N-linked glycans.
  disruption phenotype: Strongly reduces de degree of mannosylation of the core glycans and eliminates glycans resistant to alpha-1,2- mannosidase treatment.

BMT3_CANAL / Q5A846 Beta-mannosyltransferase 3; WRY family protein 9; EC 2.4.1.- from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 3 papers)
2 alignments in 111:534 / 549 (77.0%), covering up to 49.4% of PF12141, 272.7 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis. Required for addition of the second beta-mannose residue to acid-stable fraction of cell wall phosphopeptidomannan, and in elongation of beta- mannose chains on the phosphopeptidomannan acid-labile fraction.
  disruption phenotype: Impairs the elongation of beta-mannose chains on the acid-labile fraction of cell wall phosphopeptidomannan.

BMT4_KOMPG / C4R7Z8 Beta-mannosyltransferase 4; EC 2.4.1.- from Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris) (see 2 papers)
2 alignments in 90:495 / 503 (79.7%), covering up to 50.8% of PF12141, 258.4 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis. Responsible for addition of a hexose to the beta-mannose chain. Beta- mannosylation catalyzed by BMT4 masks beta-mannose epitopes recognized by monoclonal antibody (mAb) 5B2 reacting with beta-1,2-linked mannobiose as a minimal epitope.
  disruption phenotype: Leads to a size reduction of glycans resistant to alpha-mannosidase treatment.

Or search for genetic data about PF12141 in the Fitness Browser