Clusters of Characterized Proteins

Clustering the characterized proteins for pre-dehydr (prephenate dehydrogenase) in L-tyrosine biosynthesis

Or see other characterized proteins similar to pre-dehydr

Or see all steps for L-tyrosine biosynthesis

Or cluster curated proteins matching a keyword

Definition of pre-dehydr

• Curated proteins or TIGRFams with EC 1.3.1.12
• Curated proteins or TIGRFams with EC 1.3.1.13
• UniProt sequence Q8A0T8_BACTN: SubName: Full=Chorismate mutase/prephenate dehydratase (TyrA) {ECO:0000313|EMBL:AAO79038.1};
• UniProt sequence Q72EV4_DESVH: SubName: Full=Prephenate dehydrogenase {ECO:0000313|EMBL:AAS94947.1}; EC=1.3.1.12 {ECO:0000313|EMBL:AAS94947.1};
• UniProt sequence D8IR44_HERSS: SubName: Full=Prephenate dehydrogenase protein {ECO:0000313|EMBL:ADJ65170.1}; EC=1.3.1.12 {ECO:0000313|EMBL:ADJ65170.1};
• UniProt sequence A0A1L6J750: SubName: Full=Prephenate dehydrogenase {ECO:0000313|EMBL:PJI88995.1};
• Ignore hits to items matching EC 1.3.1.78 when looking for 'other' hits
• Ignore hits to items matching EC 1.3.1.43 when looking for 'other' hits
• Ignore hits to items matching EC 1.3.1.78 when looking for 'other' hits
• UniProt sequence D4GXG3: SubName: Full=Prephenate dehydrogenase {ECO:0000313|EMBL:ADE03239.1}; EC=1.3.1.12 {ECO:0000313|EMBL:ADE03239.1};
• Comment: prephenate dehydrogenase and arogenate dehydrogenase are difficult to distinguish. 1.3.1.12 and 1.3.1.13 vary by NAD(P)H cofactor. BT3933 (Q8A0T8_BACTN), DVU0464 (Q72EV4_DESVH), HSERO_RS18425 (D8IR44_HERSS), and Ga0059261_2298 (A0A1L6J750) are auxotrophic and have prephenate dehydrogenase domains (PF02153), but their specificity is unclear. HVO_1312 (D4GXG3) is auxotrophic for tyrosine and is probably a prephenate dehydrogenase (PMC4300041).

Fetched 17 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 11 of these sequences

Found 4 clusters of similar sequences. Another 5 sequences are not clustered. Download as table or as draft rules or view by cluster

Organism unknown

A8AAX2 prephenate dehydrogenase (NADP+) (EC 1.3.1.13)
PFams: CM_2, Rossmann-like, F420_oxidored, NAD_binding_2, PDH
348 amino acids: PaperBLAST, CDD (Singleton 1)

J9XQS6 prephenate dehydrogenase (EC 1.3.1.12)
PFams: PDH
287 amino acids: PaperBLAST, CDD (Cluster 1)

O30012 prephenate dehydrogenase (EC 1.3.1.12); prephenate dehydratase (EC 4.2.1.51); Chorismate mutase (EC 5.4.99.5)
PFams: PDH, CM_2, PDT, ACT
620 amino acids: PaperBLAST, CDD (Singleton 2)

O67636 prephenate dehydrogenase (EC 1.3.1.12)
PFams: NAD_binding_2, PDH
311 amino acids: PaperBLAST, CDD (Cluster 1)

P43902 prephenate dehydrogenase (EC 1.3.1.12)
PFams: CM_2, PDH
377 amino acids: PaperBLAST, CDD (Cluster 2)

Q8DUW0 prephenate dehydrogenase (EC 1.3.1.12)
PFams: F420_oxidored, NAD_binding_2, PDH
368 amino acids: PaperBLAST, CDD (Cluster 1)

O60078 Probable prephenate dehydrogenase [NADP(+)]; PRDH; EC 1.3.1.13
CH_124806 prephenate dehydrogenase [NADP+] Tyr1 (predicted); EC 1.3.1.13
PFams: NAD_binding_2, F420_oxidored, PDH
431 amino acids: PaperBLAST, CDD (Cluster 4)

O69721 Prephenate dehydrogenase; PDH; EC 1.3.1.12
PFams: F420_oxidored, PDH
323 amino acids: PaperBLAST, CDD (Cluster 1)

P20049 Prephenate dehydrogenase [NADP(+)]; PRDH; EC 1.3.1.13
PFams: NAD_binding_2, PDH
452 amino acids: PaperBLAST, CDD (Cluster 4)

Q04983 Cyclohexadienyl dehydrogenase; Arogenate dehydrogenase; ADH; Prephenate dehydrogenase; PDH; EC 1.3.1.43; EC 1.3.1.12
PFams: 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2, PDH
293 amino acids: PaperBLAST, CDD (Cluster 1)

A0A1L6J750 Prephenate dehydrogenase
249 amino acids: PaperBLAST, CDD (Cluster 3)

D4GXG3 Prephenate dehydrogenase; EC=1.3.1.12
272 amino acids: PaperBLAST, CDD (Cluster 3)

D8IR44_HERSS Prephenate dehydrogenase protein; EC=1.3.1.12
295 amino acids: PaperBLAST, CDD (Cluster 1)

Q72EV4_DESVH Prephenate dehydrogenase; EC=1.3.1.12
255 amino acids: PaperBLAST, CDD (Singleton 3)

Q8A0T8_BACTN Chorismate mutase/prephenate dehydratase (TyrA)
257 amino acids: PaperBLAST, CDD (Singleton 4)

CHORISMUTPREPHENDEHYDROG-MONOMER fused chorismate mutase/prephenate dehydrogenase (EC 5.4.99.5; EC 1.3.1.12)
PFams: CM_2, PDH
373 amino acids: PaperBLAST, CDD (Cluster 2)

MONOMER-18092 prephenate dehydrogenase (EC 1.3.1.12)
PFams: PDH
362 amino acids: PaperBLAST, CDD (Singleton 5)