Align 4-aminobutyrate aminotransferase GabT; 5-aminovalerate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT; EC 2.6.1.19; EC 2.6.1.48 (characterized)
to candidate WP_012977153.1 AZL_RS24705 4-aminobutyrate--2-oxoglutarate transaminase
Query= SwissProt::P22256 (426 letters) >NCBI__GCF_000010725.1:WP_012977153.1 Length = 429 Score = 469 bits (1208), Expect = e-137 Identities = 227/425 (53%), Positives = 307/425 (72%), Gaps = 2/425 (0%) Query: 1 MNSNKELMQRRSQAIPRGVGQIHPIFADRAENCRVWDVEGREYLDFAGGIAVLNTGHLHP 60 M +N+ + RR A+ RG+ P++ DRAEN +WDVEG+ ++DFAGGIAVLNTGH HP Sbjct: 1 MTTNQSFVARREAAVSRGISAGMPVYIDRAENAEMWDVEGKRFIDFAGGIAVLNTGHRHP 60 Query: 61 KVVAAVEAQLKKLSHTCFQVLAYEPYLELCEIMNQKVPGDFAKKTLLVTTGSEAVENAVK 120 KV+ AV+AQL + +HTC V Y+ ++EL E +N VPG KKT TTG+EAVENAVK Sbjct: 61 KVMEAVKAQLDRFTHTCAMVTPYDSFVELAEKLNALVPGREPKKTAFFTTGAEAVENAVK 120 Query: 121 IARAATKRSGTIAFSGAYHGRTHYTLALTGKVNPYSAGMGLMPGHVYRALYPCPLHGISE 180 +ARAAT R G +AFSG +HGRT T+ LTGKV PY G G P ++ +P GISE Sbjct: 121 VARAATGRPGVVAFSGGFHGRTLLTMGLTGKVVPYKVGFGPFPAEIFHVPFPNAYRGISE 180 Query: 181 DDAIASIHRIFKNDAAPEDIAAIVIEPVQGEGGFYASSPAFMQRLRALCDEHGIMLIADE 240 +++ ++ +FK+D P +AAI+IEPVQGEGGF +SP+F+Q LRA+CD+HGI++I DE Sbjct: 181 AESLKALENLFKSDVDPARVAAIIIEPVQGEGGFNIASPSFLQALRAVCDKHGIVMIVDE 240 Query: 241 VQSGAGRTGTLFAMEQMGVAPDLTTFAKSIAGGFPLAGVTGRAEVMDAVAPGGLGGTYAG 300 +Q+G RTG +FA+E G+ PDL T AKS+AGGFPL+ VTG+A +MDA PGGLGGTYAG Sbjct: 241 IQTGFARTGKMFAVEHAGIEPDLVTMAKSLAGGFPLSAVTGKAALMDAPIPGGLGGTYAG 300 Query: 301 NPIACVAALEVLKVFEQENLLQKANDLGQKLKDGLLAIAEKH--PEIGDVRGLGAMIAIE 358 +P+A AAL V+ V E+E L++++ LG+ + A+A+++ IGDVR LGAM+A+E Sbjct: 301 SPLATTAALAVINVIEEEKLVERSEKLGEHIAGRFRAMAQRNSLSVIGDVRNLGAMVAME 360 Query: 359 LFEDGDHNKPDAKLTAEIVARARDKGLILLSCGPYYNVLRILVPLTIEDAQIRQGLEIIS 418 L D + +P A LT +VA+A +KGL+LLSCG Y NV+RILVPLT DA + +GL+II Sbjct: 361 LVTDRETKEPAADLTKALVAKAAEKGLVLLSCGTYANVIRILVPLTASDALVDEGLDIIE 420 Query: 419 QCFDE 423 + +E Sbjct: 421 RSLEE 425 Lambda K H 0.320 0.137 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 510 Number of extensions: 16 Number of successful extensions: 2 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 426 Length of database: 429 Length adjustment: 32 Effective length of query: 394 Effective length of database: 397 Effective search space: 156418 Effective search space used: 156418 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 51 (24.3 bits)
This GapMind analysis is from Apr 10 2024. The underlying query database was built on Apr 09 2024.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory