Align Alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial; Beta-alanine-pyruvate aminotransferase 1; EC 2.6.1.44 (characterized)
to candidate GFF3422 PGA1_c34750 putative aminotransferase class 3
Query= SwissProt::Q940M2 (476 letters) >FitnessBrowser__Phaeo:GFF3422 Length = 1009 Score = 298 bits (764), Expect = 4e-85 Identities = 177/453 (39%), Positives = 258/453 (56%), Gaps = 23/453 (5%) Query: 39 PHIPPFVHQPRP---YKGPSADEVLQKRKKFLGPSLFHYYQKPLNIVEGKMQYLYDESGR 95 P+ P ++ P Y+ VL R+ G +L Y+ P+ ++ G +L+DE GR Sbjct: 562 PNPAPLLNLPAAQVSYQPTDKSTVLAGRRAHFGGNLSLTYRDPVMLLRGWKHHLFDEWGR 621 Query: 96 RYLDAFAGIVTVSCGHCHPDILNAITEQSKLLQHATTIYLHHAIGDFAEALAAKMPGNLK 155 YLDA+ + V GH HP I +Q K + ++ T YLH A FAE + +KMP +L+ Sbjct: 622 PYLDAYNNVPHV--GHAHPRIQAIAADQLKRM-NSNTRYLHPAQNAFAEKILSKMPDHLE 678 Query: 156 VVYFVNSGSEANELAMMMARLYTGSLEMISLRNAYHGGSSNTIGLTALNTWKYPL----- 210 V +FVNSG+EANELA+ +AR +TG+ M++ + YHG NT G ++ +K+ Sbjct: 679 VCFFVNSGTEANELALRLARAHTGAKGMVTPDHGYHG---NTTGAIDISAYKFNAKGGVG 735 Query: 211 PQGEIHHVVNPDPYRGVFGSDGSLYAKDVHDHIE------YGTSGKVAGFIAETIQGVGG 264 P + V D YRG +G D A+ D ++ + VAGFIAET VGG Sbjct: 736 PSDWVELVEVADDYRGTYGRDDPQRAQKYADLVDPAIAKLQASGHGVAGFIAETFPSVGG 795 Query: 265 AVELAPGYLKSVYEIVRNAGGVCIADEVQTGFGRTGSHYWGFQTQDVVPDIVTMAKGIGN 324 + GYL +VYE +R AGG+CIADEVQTG GR G +Y+GF+ Q PDIV + K IGN Sbjct: 796 QIIPPKGYLPAVYEKIRAAGGICIADEVQTGLGRLGEYYFGFEHQGASPDIVVLGKPIGN 855 Query: 325 GLPLGAVVTTPEIASVLA-SKILFNTFGGNPVCSAGGLAVLNVIDKEKRQEHCAEVGSHL 383 G PLG +VTT IA A F+TFGG+ + G VLN++D+E QE+ + G+ L Sbjct: 856 GHPLGVLVTTRAIADSFAQGPEFFSTFGGSTLSCRIGTEVLNIVDEEGLQENARQRGADL 915 Query: 384 IQRLKDVQKRHDIIGDVRGRGLMVGIELVSDRKDKTPAKAETSVLFEQLRELGILVGKGG 443 + L+D+Q RH IGDVRG GL +G+EL+ R D + A + + ++R+ IL+G G Sbjct: 916 LNGLRDLQSRHQAIGDVRGMGLFIGVELI--RTDGSEASEICAYVKNRMRDHRILIGSEG 973 Query: 444 LHGNVFRIKPPMCFTKDDADFLVDALDYSISRL 476 N+ +I+PP+ + + ++ LD +S L Sbjct: 974 PKDNILKIRPPLTIDAEGIEMILKTLDSILSEL 1006 Lambda K H 0.320 0.138 0.412 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 1170 Number of extensions: 61 Number of successful extensions: 6 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 476 Length of database: 1009 Length adjustment: 39 Effective length of query: 437 Effective length of database: 970 Effective search space: 423890 Effective search space used: 423890 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 54 (25.4 bits)
This GapMind analysis is from Apr 09 2024. The underlying query database was built on Apr 09 2024.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory