GapMind for Amino acid biosynthesis

 

L-phenylalanine biosynthesis

Analysis of pathway phe in 276 genomes

Genome Best path
Acidovorax caeni R-24608 cmutase, preph-dehydratase, PPYAT
Actinokineospora bangkokensis 44EHW cmutase, preph-dehydratase, PPYAT
Actinomyces timonensis 7400942 cmutase, preph-dehydratase, PPYAT
Algiphilus aromaticivorans DG1253 cmutase, preph-dehydratase, PPYAT
Algoriphagus aquaeductus T4 cmutase, preph-dehydratase, PPYAT
Algoriphagus machipongonensis PR1 cmutase, preph-dehydratase, PPYAT
Alicyclobacillus ferrooxydans TC-34 cmutase, preph-dehydratase, PPYAT
Alishewanella agri BL06 cmutase, preph-dehydratase, PPYAT
Alistipes indistinctus YIT 12060 cmutase, preph-dehydratase, PPYAT
Alistipes shahii WAL 8301 cmutase, preph-dehydratase, PPYAT
Alkalitalea saponilacus SC/BZ-SP2 cmutase, preph-dehydratase, PPYAT
Amantichitinum ursilacus IGB-41 cmutase, preph-dehydratase, PPYAT
Amphibacillus jilinensis Y1 cmutase, preph-dehydratase, PPYAT
Amphritea japonica JAMM 1866 cmutase, preph-dehydratase, PPYAT
Amycolatopsis halophila YIM 93223 cmutase, preph-dehydratase, PPYAT
Amycolatopsis xylanica CPCC 202699 cmutase, preph-dehydratase, PPYAT
Aquimarina agarilytica ZC1 cmutase, preph-dehydratase, PPYAT
Aquimarina longa SW024 cmutase, preph-dehydratase, PPYAT
Aquimarina macrocephali JAMB N27 cmutase, preph-dehydratase, PPYAT
Archaeoglobus sulfaticallidus PM70-1 cmutase, preph-dehydratase, PPYAT
Arcticibacter svalbardensis MN12-7 cmutase, preph-dehydratase, PPYAT
Ardenticatena maritima 110S cmutase, preph-dehydratase, PPYAT
Arenimonas metalli CF5-1 cmutase, preph-dehydratase, PPYAT
Arenitalea lutea P7-3-5 cmutase, preph-dehydratase, PPYAT
Azospirillum humicireducens SgZ-5 cmutase, preph-dehydratase, PPYAT
Azospirillum thiophilum BV-S cmutase, preph-dehydratase, PPYAT
Bacillus altitudinis 41KF2b cmutase, preph-dehydratase, PPYAT
Bacillus coahuilensis m4-4 cmutase, preph-dehydratase, PPYAT
Bacillus cytotoxicus NVH 391-98 cmutase, preph-dehydratase, PPYAT
Bacillus horneckiae 1P01SC cmutase, preph-dehydratase, PPYAT
Bacillus okhensis Kh10-101 cmutase, preph-dehydratase, PPYAT
Bacillus safensis FO-36b cmutase, preph-dehydratase, PPYAT
Bacillus velezensis CBMB205 cmutase, preph-dehydratase, PPYAT
Bacteroides clarus YIT 12056 cmutase, preph-dehydratase, PPYAT
Bacteroides faecis MAJ27 cmutase, preph-dehydratase, PPYAT
Bacteroides fluxus YIT 12057 cmutase, preph-dehydratase, PPYAT
Bacteroides oleiciplenus YIT 12058 cmutase, preph-dehydratase, PPYAT
Barnesiella intestinihominis YIT 11860 cmutase, preph-dehydratase, PPYAT
Belnapia rosea CPCC 100156 cmutase, preph-dehydratase, PPYAT
Bizionia argentinensis JUB59 cmutase, preph-dehydratase, PPYAT
Bradyrhizobium diazoefficiens USDA110 cmutase, ptransferase, aro-dehydratase
Brevibacterium jeotgali SJ5-8 cmutase, preph-dehydratase, PPYAT
Brucella inopinata BO1 cmutase, preph-dehydratase, PPYAT
Brucella microti CCM 4915 cmutase, preph-dehydratase, PPYAT
Bryobacter aggregatus MPL3 cmutase, ptransferase, aro-dehydratase
Caldicellulosiruptor hydrothermalis 108 cmutase, preph-dehydratase, PPYAT
Caldicellulosiruptor kronotskyensis 2002 cmutase, preph-dehydratase, PPYAT
Carboxydothermus pertinax Ug1 cmutase, preph-dehydratase, PPYAT
Catellicoccus marimammalium M35/04/3 cmutase, ptransferase, aro-dehydratase
Chromobacterium vaccinii MWU205 cmutase, preph-dehydratase, PPYAT
Chryseobacterium angstadtii KM cmutase, preph-dehydratase, PPYAT
Chryseobacterium arthrosphaerae CC-VM-7 cmutase, preph-dehydratase, PPYAT
Chryseobacterium viscerum 687B-08 cmutase, preph-dehydratase, PPYAT
Cloacibacillus porcorum CL-84 cmutase, ptransferase, aro-dehydratase
Cobetia crustatorum JO1 cmutase, preph-dehydratase, PPYAT
Collimonas arenae Ter10 cmutase, preph-dehydratase, PPYAT
Collimonas pratensis Ter91 cmutase, ptransferase, aro-dehydratase
Collinsella tanakaei YIT 12063 cmutase, preph-dehydratase, PPYAT
Coprobacter fastidiosus NSB1 cmutase, preph-dehydratase, PPYAT
Corynebacterium deserti GIMN1.010 cmutase, preph-dehydratase, PPYAT
Corynebacterium frankenforstense ST18 cmutase, preph-dehydratase, PPYAT
Corynebacterium lactis RW2-5 cmutase, preph-dehydratase, PPYAT
Croceitalea dokdonensis DOKDO 023 cmutase, preph-dehydratase, PPYAT
Cronobacter condimenti 1330 cmutase, preph-dehydratase, PPYAT
Cronobacter muytjensii ATCC 51329 cmutase, preph-dehydratase, PPYAT
Cronobacter universalis NCTC 9529 cmutase, preph-dehydratase, PPYAT
Desulfatitalea tepidiphila S28bF cmutase, ptransferase, aro-dehydratase
Desulfotomaculum hydrothermale Lam5 cmutase, ptransferase, aro-dehydratase
Dethiosulfovibrio salsuginis USBA 82 cmutase, preph-dehydratase, PPYAT
Devosia chinhatensis IPL18 cmutase, preph-dehydratase, PPYAT
Devriesea agamarum IMP2 cmutase, preph-dehydratase, PPYAT
Dialister succinatiphilus YIT 11850 cmutase, preph-dehydratase, PPYAT
Dietzia timorensis ID05-A0528 cmutase, preph-dehydratase, PPYAT
Dokdonella koreensis DS-123 cmutase, preph-dehydratase, PPYAT
Domibacillus robiginosus WS 4628 cmutase, preph-dehydratase, PPYAT
Duganella sacchari Sac-22 cmutase, preph-dehydratase, PPYAT
Dyadobacter tibetensis Y620-1 cmutase, preph-dehydratase, PPYAT
Dyella jiangningensis SBZ3-12 cmutase, preph-dehydratase, PPYAT
Endozoicomonas montiporae CL-33 cmutase, preph-dehydratase, PPYAT
Enterococcus termitis LMG 8895 cmutase, preph-dehydratase, PPYAT
Enterorhabdus caecimuris B7 cmutase, preph-dehydratase, PPYAT
Epibacterium ulvae U95 cmutase, preph-dehydratase, PPYAT
Erythrobacter gangjinensis K7-2 cmutase, preph-dehydratase, PPYAT
Erythrobacter marinus HWDM-33 cmutase, preph-dehydratase, PPYAT
Ethanoligenens harbinense YUAN-3 cmutase, preph-dehydratase, PPYAT
Fervidicella metallireducens AeB cmutase, ptransferase, aro-dehydratase
Fibrella aestuarina BUZ 2 cmutase, preph-dehydratase, PPYAT
Flammeovirga pacifica WPAGA1 cmutase, preph-dehydratase, PPYAT
Flaviramulus ichthyoenteri Th78 cmutase, preph-dehydratase, PPYAT
Flavobacterium beibuense F44-8 cmutase, preph-dehydratase, PPYAT
Flavobacterium glycines Gm-149 cmutase, preph-dehydratase, PPYAT
Flavobacterium sp. LM5 cmutase, preph-dehydratase, PPYAT
Flavobacterium ummariense DS-12 cmutase, ptransferase, aro-dehydratase
Frischella perrara PEB0191 cmutase, preph-dehydratase, PPYAT
Galbibacter marinus ck-I2-15 cmutase, preph-dehydratase, PPYAT
Gallaecimonas xiamenensis 3-C-1 cmutase, preph-dehydratase, PPYAT
Geobacter daltonii FRC-32 cmutase, preph-dehydratase, PPYAT
Gillisia marina CBA3202 cmutase, preph-dehydratase, PPYAT
Gracilibacillus halophilus YIM-C55.5 cmutase, preph-dehydratase, PPYAT
Granulicella mallensis MP5ACTX8 cmutase, ptransferase, aro-dehydratase
Granulicella tundricola MP5ACTX9 cmutase, preph-dehydratase, PPYAT
Hafnia paralvei ATCC 29927 cmutase, preph-dehydratase, PPYAT
Haladaptatus cibarius D43 cmutase, preph-dehydratase, PPYAT
Halioglobus japonicus S1-36 cmutase, preph-dehydratase, PPYAT
Halobacillus alkaliphilus FP5 cmutase, preph-dehydratase, PPYAT
Halococcus hamelinensis 100A6 cmutase, preph-dehydratase, PPYAT
Halomonas salina B6 cmutase, preph-dehydratase, PPYAT
Halomonas smyrnensis AAD6 cmutase, preph-dehydratase, PPYAT
Halomonas stevensii S18214 cmutase, preph-dehydratase, PPYAT
Halomonas titanicae BH1 cmutase, preph-dehydratase, PPYAT
Halomonas xinjiangensis TRM 0175 cmutase, preph-dehydratase, PPYAT
Halopiger salifodinae KCY07-B2 cmutase, preph-dehydratase, PPYAT
Halostagnicola larsenii XH-48 cmutase, preph-dehydratase, PPYAT
Haloterrigena daqingensis JX313 cmutase, preph-dehydratase, PPYAT
Herbaspirillum aquaticum IEH 4430 cmutase, preph-dehydratase, PPYAT
Hippea alviniae EP5-r cmutase, preph-dehydratase, PPYAT
Hippea jasoniae Mar08-272r cmutase, preph-dehydratase, PPYAT
Hoeflea phototrophica DFL-43 cmutase, preph-dehydratase, PPYAT
Hyphomicrobium nitrativorans NL23 cmutase, preph-dehydratase, PPYAT
Imtechella halotolerans K1 cmutase, preph-dehydratase, PPYAT
Indibacter alkaliphilus LW1 cmutase, preph-dehydratase, PPYAT
Jannaschia aquimarina GSW-M26 cmutase, preph-dehydratase, PPYAT
Jeotgalibacillus soli P9 cmutase, preph-dehydratase, PPYAT
Kangiella geojedonensis YCS-5 cmutase, ptransferase, aro-dehydratase
Knoellia flava TL1 cmutase, preph-dehydratase, PPYAT
Kocuria flava HO-9041 cmutase, preph-dehydratase, PPYAT
Kocuria turfanensis HO-9042 cmutase, preph-dehydratase, PPYAT
Laceyella sediminis RHA1 cmutase, preph-dehydratase, PPYAT
Lacinutrix algicola AKS293 cmutase, preph-dehydratase, PPYAT
Lacinutrix himadriensis E4-9a cmutase, ptransferase, aro-dehydratase
Lacinutrix mariniflava AKS432 cmutase, preph-dehydratase, PPYAT
Lactobacillus curieae CCTCC M 2011381 cmutase, preph-dehydratase, PPYAT
Lactobacillus delbrueckii ZN7a-9 cmutase, preph-dehydratase, PPYAT
Lactobacillus hokkaidonensis LOOC260 cmutase, preph-dehydratase, PPYAT
Lactobacillus oryzae SG293 cmutase, preph-dehydratase, PPYAT
Lactobacillus pobuzihii E100301 cmutase, preph-dehydratase, PPYAT
Lactobacillus shenzhenensis LY-73 cmutase, preph-dehydratase, PPYAT
Lactobacillus silagei IWT126 cmutase, preph-dehydratase, PPYAT
Leeuwenhoekiella blandensis MED217 cmutase, preph-dehydratase, PPYAT
Lentibacillus jeotgali Grbi cmutase, preph-dehydratase, PPYAT
Limnohabitans curvus MWH-C5 cmutase, preph-dehydratase, PPYAT
Limnohabitans parvus II-B4 cmutase, preph-dehydratase, PPYAT
Listeria fleischmannii LU2006-1 cmutase, preph-dehydratase, PPYAT
Luteimonas huabeiensis HB2 cmutase, preph-dehydratase, PPYAT
Luteipulveratus mongoliensis MN07-A0370 cmutase, preph-dehydratase, PPYAT
Lutibaculum baratangense AMV1 cmutase, preph-dehydratase, PPYAT
Lysobacter daejeonensis GH1-9 cmutase, preph-dehydratase, PPYAT
Magnetovibrio blakemorei MV-1 cmutase, preph-dehydratase, PPYAT
Marinicella litoralis KMM 3900 cmutase, preph-dehydratase, PPYAT
Mariniradius saccharolyticus AK6 cmutase, preph-dehydratase, PPYAT
Marinobacter algicola DG893 cmutase, preph-dehydratase, PPYAT
Marinobacter guineae M3B cmutase, preph-dehydratase, PPYAT
Marinobacter psychrophilus 20041 cmutase, preph-dehydratase, PPYAT
Marinomonas arctica 328 cmutase, preph-dehydratase, PPYAT
Marivita geojedonensis DPG-138 cmutase, preph-dehydratase, PPYAT
Martelella endophytica YC6887 cmutase, preph-dehydratase, PPYAT
Megamonas funiformis YIT 11815 cmutase, preph-dehydratase, PPYAT
Mesorhizobium ciceri WSM1271 cmutase, preph-dehydratase, PPYAT
Methanobacterium arcticum M2 cmutase, preph-dehydratase, PPYAT
Methanobacterium veterum MK4 cmutase, preph-dehydratase, PPYAT
Methanocella arvoryzae MRE50 cmutase, preph-dehydratase, PPYAT
Methanococcus aeolicus Nankai-3 cmutase, preph-dehydratase, PPYAT
Methanoculleus horonobensis T10 cmutase, preph-dehydratase, PPYAT
Methanolinea tarda NOBI-1 cmutase, preph-dehydratase, PPYAT
Methanosarcina soligelidi SMA-21 cmutase, preph-dehydratase, PPYAT
Methanospirillum lacunae Ki8-1 cmutase, preph-dehydratase, PPYAT
Methanospirillum stamsii Pt1 cmutase, preph-dehydratase, PPYAT
Methylibium petroleiphilum PM1 cmutase, preph-dehydratase, PPYAT
Methylobacterium gossipiicola Gh-105 cmutase, preph-dehydratase, PPYAT
Methylocapsa aurea KYG cmutase, preph-dehydratase, PPYAT
Methylotenera versatilis 301 cmutase, preph-dehydratase, PPYAT
Microbacterium profundi Shh49 cmutase, preph-dehydratase, PPYAT
Microvirga lotononidis WSM3557 cmutase, preph-dehydratase, PPYAT
Moritella dasanensis ArB 0140 cmutase, preph-dehydratase, PPYAT
Mucilaginibacter gossypii Gh-67 cmutase, preph-dehydratase, PPYAT
Mucilaginibacter gossypiicola Gh-48 cmutase, preph-dehydratase, PPYAT
Mucilaginibacter mallensis MP1X4 cmutase, preph-dehydratase, PPYAT
Nafulsella turpanensis ZLM-10 cmutase, preph-dehydratase, PPYAT
Natronomonas moolapensis 8.8.11 cmutase, preph-dehydratase, PPYAT
Nautilia profundicola AmH cmutase, preph-dehydratase, PPYAT
Neiella marina J221 cmutase, preph-dehydratase, PPYAT
Neptunomonas antarctica S3-22 cmutase, ptransferase, aro-dehydratase
Nocardioides daejeonensis MJ31 cmutase, preph-dehydratase, PPYAT
Nocardioides dokdonensis FR1436 cmutase, preph-dehydratase, PPYAT
Nocardiopsis baichengensis YIM 90130 cmutase, preph-dehydratase, PPYAT
Nocardiopsis gilva YIM 90087 cmutase, preph-dehydratase, PPYAT
Novosphingobium barchaimii LL02 cmutase, preph-dehydratase, PPYAT
Novosphingobium fuchskuhlense FNE08-7 cmutase, preph-dehydratase, PPYAT
Novosphingobium lindaniclasticum LE124 cmutase, preph-dehydratase, PPYAT
Oceanisphaera arctica V1-41 cmutase, preph-dehydratase, PPYAT
Ochrobactrum rhizosphaerae PR17 cmutase, preph-dehydratase, PPYAT
Ochrobactrum thiophenivorans DSM 7216 cmutase, preph-dehydratase, PPYAT
Oscillibacter ruminantium GH1 cmutase, preph-dehydratase, PPYAT
Paenisporosarcina indica PN2 cmutase, preph-dehydratase, PPYAT
Palaeococcus pacificus DY20341 cmutase, ptransferase, aro-dehydratase
Paludibacter propionicigenes WB4 cmutase, preph-dehydratase, PPYAT
Pandoraea thiooxydans ATSB16 cmutase, ptransferase, aro-dehydratase
Pantoea rwandensis LMG 26275 cmutase, ptransferase, aro-dehydratase
Pedobacter arcticus A12 cmutase, preph-dehydratase, PPYAT
Photobacterium gaetbulicola Gung47 cmutase, preph-dehydratase, PPYAT
Photobacterium jeanii R-40508 cmutase, preph-dehydratase, PPYAT
Phyllobacterium brassicacearum STM 196 cmutase, preph-dehydratase, PPYAT
Phyllobacterium endophyticum PEPV15 cmutase, preph-dehydratase, PPYAT
Phyllobacterium leguminum ORS 1419 cmutase, preph-dehydratase, PPYAT
Planktomarina temperata RCA23 cmutase, preph-dehydratase, PPYAT
Planococcus halocryophilus Or1 cmutase, preph-dehydratase, PPYAT
Pleomorphomonas diazotrophica R5-392 cmutase, preph-dehydratase, PPYAT
Polaribacter dokdonensis DSW-5 cmutase, preph-dehydratase, PPYAT
Pontibacillus litoralis JSM 072002 cmutase, preph-dehydratase, PPYAT
Pontibacter lucknowensis DM9 cmutase, preph-dehydratase, PPYAT
Pontibacter ramchanderi LP43 cmutase, preph-dehydratase, PPYAT
Pontimonas salivibrio CL-TW6 cmutase, preph-dehydratase, PPYAT
Porphyrobacter dokdonensis DSW-74 cmutase, preph-dehydratase, PPYAT
Pseudoalteromonas arctica A 37-1-2 cmutase, preph-dehydratase, PPYAT
Pseudomonas baetica a390 cmutase, preph-dehydratase, PPYAT
Pseudomonas litoralis 2SM5 cmutase, preph-dehydratase, PPYAT
Pseudomonas taeanensis MS-3 cmutase, preph-dehydratase, PPYAT
Pseudovibrio axinellae Ad2 cmutase, preph-dehydratase, PPYAT
Psychrobacter arcticus 273-4 cmutase, preph-dehydratase, PPYAT
Psychrobacter cryohalolentis K5 cmutase, preph-dehydratase, PPYAT
Psychromonas ingrahamii 37 cmutase, preph-dehydratase, PPYAT
Psychromonas ossibalaenae JAMM 0738 cmutase, preph-dehydratase, PPYAT
Rhizobium freirei PRF 81 cmutase, preph-dehydratase, PPYAT
Rhizobium grahamii CCGE 502 cmutase, preph-dehydratase, PPYAT
Rhizobium subbaraonis JC85 cmutase, preph-dehydratase, PPYAT
Rhodanobacter denitrificans 2APBS1 cmutase, preph-dehydratase, PPYAT
Rhodobacter johrii JA192 cmutase, preph-dehydratase, PPYAT
Rhodobacter maris JA276 cmutase, preph-dehydratase, PPYAT
Rhodobacter ovatus JA234 cmutase, preph-dehydratase, PPYAT
Rhodobacter viridis JA737 cmutase, preph-dehydratase, PPYAT
Rhodococcus qingshengii djl-6-2 cmutase, preph-dehydratase, PPYAT
Rhodopseudomonas pseudopalustris DSM 123 cmutase, preph-dehydratase, PPYAT
Roseateles aquatilis CCUG 48205 cmutase, preph-dehydratase, PPYAT
Roseivirga spongicola UST030701-084 cmutase, ptransferase, aro-dehydratase
Rubrivirga marina SAORIC-28 cmutase, preph-dehydratase, PPYAT
Ruegeria conchae TW15 cmutase, preph-dehydratase, PPYAT
Saccharomonospora marina XMU15 cmutase, preph-dehydratase, PPYAT
Salinicoccus carnicancri Crm cmutase, preph-dehydratase, PPYAT
Serinicoccus profundi MCCC 1A05965 cmutase, preph-dehydratase, PPYAT
Shewanella halifaxensis HAW-EB4 cmutase, preph-dehydratase, PPYAT
Skermanella stibiiresistens SB22 cmutase, preph-dehydratase, PPYAT
Snodgrassella alvi wkB2 cmutase, preph-dehydratase, PPYAT
Sphaerochaeta globosa Buddy cmutase, preph-dehydratase, PPYAT
Sphaerochaeta pleomorpha Grapes cmutase, preph-dehydratase, PPYAT
Sphingobium baderi LL03 cmutase, preph-dehydratase, PPYAT
Sphingobium czechense LL01 cmutase, preph-dehydratase, PPYAT
Sphingobium quisquiliarum P25 cmutase, preph-dehydratase, PPYAT
Sphingomonas histidinilytica UM2 cmutase, preph-dehydratase, PPYAT
Sphingomonas indica Dd16 cmutase, preph-dehydratase, PPYAT
Sphingomonas laterariae LNB2 cmutase, preph-dehydratase, PPYAT
Sphingopyxis indica DS15 cmutase, preph-dehydratase, PPYAT
Sphingopyxis terrae UI2 cmutase, preph-dehydratase, PPYAT
Sporolactobacillus vineae SL153 cmutase, preph-dehydratase, PPYAT
Streptacidiphilus oryzae TH49 cmutase, preph-dehydratase, PPYAT
Streptococcus anginosus CCUG 39159 cmutase, preph-dehydratase, PPYAT
Streptococcus massiliensis 4401825 cmutase, preph-dehydratase, PPYAT
Streptococcus oralis 7747 cmutase, preph-dehydratase, PPYAT
Streptococcus oralis AZ_3a cmutase, preph-dehydratase, PPYAT
Streptomyces kebangsaanensis SUK12 cmutase, preph-dehydratase, PPYAT
Succinatimonas hippei YIT 12066 cmutase, preph-dehydratase, PPYAT
Sulfurimonas gotlandica GD1 cmutase, preph-dehydratase, PPYAT
Tatumella morbirosei LMG 23360 cmutase, ptransferase, aro-dehydratase
Thauera humireducens SgZ-1 cmutase, preph-dehydratase, PPYAT
Thermoactinomyces daqus H-18 cmutase, preph-dehydratase, PPYAT
Thermobifida halotolerans YIM 90462 cmutase, preph-dehydratase, PPYAT
Thermodesulfovibrio aggregans TGE-P1 cmutase, preph-dehydratase, PPYAT
Thermophagus xiamenensis HS1 cmutase, preph-dehydratase, PPYAT
Thermovenabulum gondwanense R270 cmutase, preph-dehydratase, PPYAT
Thioclava dalianensis DLFJ1-1 cmutase, preph-dehydratase, PPYAT
Thiohalospira halophila HL 3 cmutase, preph-dehydratase, PPYAT
Tistlia consotensis USBA 355 cmutase, preph-dehydratase, PPYAT
Vagococcus penaei CD276 cmutase, preph-dehydratase, PPYAT
Verminephrobacter eiseniae EF01-2 cmutase, preph-dehydratase, PPYAT
Weissella oryzae SG25 cmutase, preph-dehydratase, PPYAT
Williamsia sterculiae CPCC 203464 cmutase, preph-dehydratase, PPYAT
Yersinia intermedia Y228 cmutase, preph-dehydratase, PPYAT

Confidence: high confidence medium confidence low confidence
? – known gap: despite the lack of a good candidate for this step, this organism (or a related organism) performs the pathway

This GapMind analysis is from Jul 26 2024. The underlying query database was built on Jul 25 2024.

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About GapMind

Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.

A candidate for a step is "high confidence" if either:

where "other" refers to the best ublast hit to a sequence that is not annotated as performing this step (and is not "ignored").

Otherwise, a candidate is "medium confidence" if either:

Other blast hits with at least 50% coverage are "low confidence."

Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:

GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).

For more information, see:

If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know

by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory