GapMind for Amino acid biosynthesis

 

L-proline biosynthesis

Analysis of pathway pro in 276 genomes

Genome Best path
Acidovorax caeni R-24608 proB, proA, proC
Actinokineospora bangkokensis 44EHW argJ, argB, argC, argD, OAT, proC
Actinomyces timonensis 7400942 proB, proA, proC
Algiphilus aromaticivorans DG1253 proB, proA, proC
Algoriphagus aquaeductus T4 proB, proA, proC
Algoriphagus machipongonensis PR1 argJ, argB, argC, argD, OAT, proC
Alicyclobacillus ferrooxydans TC-34 argA, argB, argC, argD, argE, OAT, proC
Alishewanella agri BL06 proB, proA, proC
Alistipes indistinctus YIT 12060 proB, proA, proC
Alistipes shahii WAL 8301 proB, proA, proC
Alkalitalea saponilacus SC/BZ-SP2 proB, proA, proC
Amantichitinum ursilacus IGB-41 proB, proA, proC
Amphibacillus jilinensis Y1 proB, proA, proC
Amphritea japonica JAMM 1866 proB, proA, proC
Amycolatopsis halophila YIM 93223 argJ, argB, argC, argD, OAT, proC
Amycolatopsis xylanica CPCC 202699 argJ, argB, argC, argD, OAT, proC
Aquimarina agarilytica ZC1 argA, argB, argC, argD, argE?, OAT, proC
Aquimarina longa SW024 argA, argB, argC, argD, argE?, OAT, proC
Aquimarina macrocephali JAMB N27 argA, argB, argC, argD, argE?, OAT, proC
Archaeoglobus sulfaticallidus PM70-1 argJ, argB, argC, argD, cyclodeaminase
Arcticibacter svalbardensis MN12-7 proB, proA, proC
Ardenticatena maritima 110S argJ, argB, argC, argD, cyclodeaminase
Arenimonas metalli CF5-1 argA, argB, argC, argD, argE, cyclodeaminase
Arenitalea lutea P7-3-5 proB, proA, proC
Azospirillum humicireducens SgZ-5 argA, argB, argC, argD, argE, cyclodeaminase
Azospirillum thiophilum BV-S argA, argB, argC, argD, argE, cyclodeaminase
Bacillus altitudinis 41KF2b argJ, argB, argC, argD, OAT, proC
Bacillus coahuilensis m4-4 proB, proA, proC
Bacillus cytotoxicus NVH 391-98 argJ, argB, argC, argD, OAT, proC
Bacillus horneckiae 1P01SC argJ, argB, argC, argD, OAT, proC
Bacillus okhensis Kh10-101 argJ, argB, argC, argD, OAT, proC
Bacillus safensis FO-36b argJ, argB, argC, argD, OAT, proC
Bacillus velezensis CBMB205 argJ, argB, argC, argD, OAT, proC
Bacteroides clarus YIT 12056 proB, proA, proC
Bacteroides faecis MAJ27 proB, proA, proC
Bacteroides fluxus YIT 12057 proB, proA, proC
Bacteroides oleiciplenus YIT 12058 proB, proA, proC
Barnesiella intestinihominis YIT 11860 proB, proA, proC
Belnapia rosea CPCC 100156 proB, proA, proC
Bizionia argentinensis JUB59 proB, proA, proC
Bradyrhizobium diazoefficiens USDA110 proB, proA, proC
Brevibacterium jeotgali SJ5-8 proB, proA, proC
Brucella inopinata BO1 argJ, argB, argC, argD, cyclodeaminase
Brucella microti CCM 4915 argJ, argB, argC, argD, cyclodeaminase
Bryobacter aggregatus MPL3 argJ, argB, argC, argD, OAT, proC
Caldicellulosiruptor hydrothermalis 108 proB, proA, proC
Caldicellulosiruptor kronotskyensis 2002 proB, proA, proC
Carboxydothermus pertinax Ug1 proB, proA, proC
Catellicoccus marimammalium M35/04/3 proB, proA, proC
Chromobacterium vaccinii MWU205 proB, proA, proC
Chryseobacterium angstadtii KM argJ, argB, argC, argD, OAT, proC
Chryseobacterium arthrosphaerae CC-VM-7 argJ, argB, argC, argD, OAT, proC
Chryseobacterium viscerum 687B-08 argA, argB, argC, argD, argE, OAT, proC
Cloacibacillus porcorum CL-84 lysW, argX, lysZ, lysY, lysJ, lysK, OAT, proC
Cobetia crustatorum JO1 proB, proA, proC
Collimonas arenae Ter10 proB, proA, proC
Collimonas pratensis Ter91 argA, argB, argC, argD, argE, OAT, proC
Collinsella tanakaei YIT 12063 proB, proA, proC
Coprobacter fastidiosus NSB1 proB, proA, proC
Corynebacterium deserti GIMN1.010 proB, proA, proC
Corynebacterium frankenforstense ST18 proB, proA, proC
Corynebacterium lactis RW2-5 proB, proA, proC
Croceitalea dokdonensis DOKDO 023 argA, argB, argC, argD, argE?, OAT, proC
Cronobacter condimenti 1330 proB, proA, proC
Cronobacter muytjensii ATCC 51329 proB, proA, proC
Cronobacter universalis NCTC 9529 proB, proA, proC
Desulfatitalea tepidiphila S28bF proB, proA, proC
Desulfotomaculum hydrothermale Lam5 proB, proA, proC
Dethiosulfovibrio salsuginis USBA 82 proB, proA, proC
Devosia chinhatensis IPL18 proB, proA, proC
Devriesea agamarum IMP2 argJ, argB, argC, argD, OAT, proC
Dialister succinatiphilus YIT 11850 proB, proA, proC
Dietzia timorensis ID05-A0528 proB, proA, proC
Dokdonella koreensis DS-123 proB, proA, proC
Domibacillus robiginosus WS 4628 argJ, argB, argC, argD, OAT, proC
Duganella sacchari Sac-22 proB, proA, proC
Dyadobacter tibetensis Y620-1 proB, proA, proC
Dyella jiangningensis SBZ3-12 proB, proA, proC
Endozoicomonas montiporae CL-33 proB, proA, proC
Enterococcus termitis LMG 8895 proB, proA, proC
Enterorhabdus caecimuris B7 proB, proA, proC
Epibacterium ulvae U95 argA, argB, argC, argD, argE, cyclodeaminase
Erythrobacter gangjinensis K7-2 proB, proA, proC
Erythrobacter marinus HWDM-33 proB, proA, proC
Ethanoligenens harbinense YUAN-3 argJ, argB, argC, argD, OAT, proC
Fervidicella metallireducens AeB proB, proA, proC
Fibrella aestuarina BUZ 2 proB, proA, proC
Flammeovirga pacifica WPAGA1 proB, proA, proC
Flaviramulus ichthyoenteri Th78 argA, argB, argC, argD, argE?, OAT, proC
Flavobacterium beibuense F44-8 argA, argB, argC, argD, argE?, OAT, proC
Flavobacterium glycines Gm-149 proB, proA, proC
Flavobacterium sp. LM5 proB, proA, proC
Flavobacterium ummariense DS-12 proB, proA, proC
Frischella perrara PEB0191 proB, proA, proC
Galbibacter marinus ck-I2-15 proB, proA, proC
Gallaecimonas xiamenensis 3-C-1 proB, proA, proC
Geobacter daltonii FRC-32 proB, proA, proC
Gillisia marina CBA3202 proB, proA, proC
Gracilibacillus halophilus YIM-C55.5 proB, proA, proC
Granulicella mallensis MP5ACTX8 argA, argB, argC, argD, argE, OAT, proC
Granulicella tundricola MP5ACTX9 argJ, argB, argC, argD, OAT, proC
Hafnia paralvei ATCC 29927 proB, proA, proC
Haladaptatus cibarius D43 lysW, argX, lysZ, lysY, lysJ, lysK, cyclodeaminase
Halioglobus japonicus S1-36 proB, proA, proC
Halobacillus alkaliphilus FP5 argJ, argB, argC, argD, OAT, proC
Halococcus hamelinensis 100A6 lysW, argX, lysZ, lysY, lysJ, lysK, cyclodeaminase
Halomonas salina B6 proB, proA, proC
Halomonas smyrnensis AAD6 argA, argB, argC, argD, argE, OAT, proC
Halomonas stevensii S18214 proB, proA, proC
Halomonas titanicae BH1 proB, proA, proC
Halomonas xinjiangensis TRM 0175 proB, proA, proC
Halopiger salifodinae KCY07-B2 lysW, argX, lysZ, lysY, lysJ, lysK, OAT, proC
Halostagnicola larsenii XH-48 lysW, argX, lysZ, lysY, lysJ, lysK, cyclodeaminase
Haloterrigena daqingensis JX313 lysW, argX, lysZ, lysY, lysJ, lysK, cyclodeaminase
Herbaspirillum aquaticum IEH 4430 argA, argB, argC, argD, argE, cyclodeaminase
Hippea alviniae EP5-r proB, proA, proC
Hippea jasoniae Mar08-272r proB, proA, proC
Hoeflea phototrophica DFL-43 argA, argB, argC, argD, argE, cyclodeaminase
Hyphomicrobium nitrativorans NL23 proB, proA, proC
Imtechella halotolerans K1 argA, argB, argC, argD, argE?, OAT, proC
Indibacter alkaliphilus LW1 argJ, argB, argC, argD, OAT, proC
Jannaschia aquimarina GSW-M26 proB, proA, proC
Jeotgalibacillus soli P9 argJ, argB, argC, argD, OAT, proC
Kangiella geojedonensis YCS-5 proB, proA, proC
Knoellia flava TL1 argJ, argB, argC, argD, OAT, proC
Kocuria flava HO-9041 proB, proA, proC
Kocuria turfanensis HO-9042 argJ, argB, argC, argD, OAT, proC
Laceyella sediminis RHA1 argJ, argB, argC, argD, OAT, proC
Lacinutrix algicola AKS293 argA, argB, argC, argD, argE?, OAT, proC
Lacinutrix himadriensis E4-9a argA, argB, argC, argD, argE?, OAT, proC
Lacinutrix mariniflava AKS432 argA, argB, argC, argD, argE?, OAT, proC
Lactobacillus curieae CCTCC M 2011381 proB, proA, proC
Lactobacillus delbrueckii ZN7a-9 proB, proA, proC
Lactobacillus hokkaidonensis LOOC260 proB, proA, proC
Lactobacillus oryzae SG293 proB, proA, proC
Lactobacillus pobuzihii E100301 proB, proA, proC
Lactobacillus shenzhenensis LY-73 proB, proA, proC
Lactobacillus silagei IWT126 proB, proA, proC
Leeuwenhoekiella blandensis MED217 proB, proA, proC
Lentibacillus jeotgali Grbi argJ, argB, argC, argD, OAT, proC
Limnohabitans curvus MWH-C5 proB, proA, proC
Limnohabitans parvus II-B4 argA, argB, argC, argD, argE, cyclodeaminase
Listeria fleischmannii LU2006-1 proB, proA, proC
Luteimonas huabeiensis HB2 proB, proA, proC
Luteipulveratus mongoliensis MN07-A0370 proB, proA, proC
Lutibaculum baratangense AMV1 proB, proA, proC
Lysobacter daejeonensis GH1-9 argA, argB, argC, argD, argE, cyclodeaminase
Magnetovibrio blakemorei MV-1 proB, proA, proC
Marinicella litoralis KMM 3900 proB, proA, proC
Mariniradius saccharolyticus AK6 proB, proA, proC
Marinobacter algicola DG893 proB, proA, proC
Marinobacter guineae M3B proB, proA, proC
Marinobacter psychrophilus 20041 proB, proA, proC
Marinomonas arctica 328 proB, proA, proC
Marivita geojedonensis DPG-138 argA, argB, argC, argD, argE, cyclodeaminase
Martelella endophytica YC6887 argA, argB, argC, argD, argE, cyclodeaminase
Megamonas funiformis YIT 11815 proB, proA, proC
Mesorhizobium ciceri WSM1271 argA, argB, argC, argD, argE, cyclodeaminase
Methanobacterium arcticum M2 argJ, argB, argC, argD, cyclodeaminase
Methanobacterium veterum MK4 argJ, argB, argC, argD, cyclodeaminase
Methanocella arvoryzae MRE50 argJ, argB, argC, argD, cyclodeaminase
Methanococcus aeolicus Nankai-3 argJ, argB, argC, argD, cyclodeaminase
Methanoculleus horonobensis T10 argJ, argB, argC, argD, cyclodeaminase
Methanolinea tarda NOBI-1 argJ, argB, argC, argD, cyclodeaminase
Methanosarcina soligelidi SMA-21 proB, proA, proC
Methanospirillum lacunae Ki8-1 argJ, argB, argC, argD, cyclodeaminase
Methanospirillum stamsii Pt1 argJ, argB, argC, argD, cyclodeaminase
Methylibium petroleiphilum PM1 argJ, argB, argC, argD, OAT, proC
Methylobacterium gossipiicola Gh-105 proB, proA, proC
Methylocapsa aurea KYG argA, argB, argC, argD, argE, OAT, proC
Methylotenera versatilis 301 proB, proA, proC
Microbacterium profundi Shh49 argJ, argB, argC, argD, OAT, proC
Microvirga lotononidis WSM3557 argA, argB, argC, argD, argE, OAT, proC
Moritella dasanensis ArB 0140 argA, argB, argC, argD, argE, cyclodeaminase
Mucilaginibacter gossypii Gh-67 proB, proA, proC
Mucilaginibacter gossypiicola Gh-48 proB, proA, proC
Mucilaginibacter mallensis MP1X4 proB, proA, proC
Nafulsella turpanensis ZLM-10 proB, proA, proC
Natronomonas moolapensis 8.8.11 proB, proA, proC
Nautilia profundicola AmH proB, proA, proC
Neiella marina J221 proB, proA, proC
Neptunomonas antarctica S3-22 proB, proA, proC
Nocardioides daejeonensis MJ31 argJ, argB, argC, argD, OAT, proC
Nocardioides dokdonensis FR1436 argJ, argB, argC, argD, OAT, proC
Nocardiopsis baichengensis YIM 90130 argJ, argB, argC, argD, OAT, proC
Nocardiopsis gilva YIM 90087 argJ, argB, argC, argD, OAT, proC
Novosphingobium barchaimii LL02 proB, proA, proC
Novosphingobium fuchskuhlense FNE08-7 proB, proA, proC
Novosphingobium lindaniclasticum LE124 proB, proA, proC
Oceanisphaera arctica V1-41 proB, proA, proC
Ochrobactrum rhizosphaerae PR17 argJ, argB, argC, argD, cyclodeaminase
Ochrobactrum thiophenivorans DSM 7216 argA, argB, argC, argD, argE, cyclodeaminase
Oscillibacter ruminantium GH1 proB, proA, proC
Paenisporosarcina indica PN2 proB, proA, proC
Palaeococcus pacificus DY20341 proB, proA, proC
Paludibacter propionicigenes WB4 proB, proA, proC
Pandoraea thiooxydans ATSB16 argA, argB, argC, argD, argE, cyclodeaminase
Pantoea rwandensis LMG 26275 proB, proA, proC
Pedobacter arcticus A12 proB, proA, proC
Photobacterium gaetbulicola Gung47 proB, proA, proC
Photobacterium jeanii R-40508 proB, proA, proC
Phyllobacterium brassicacearum STM 196 argA, argB, argC, argD, argE, OAT, proC
Phyllobacterium endophyticum PEPV15 argJ, argB, argC, argD, OAT, proC
Phyllobacterium leguminum ORS 1419 argJ, argB, argC, argD, cyclodeaminase
Planktomarina temperata RCA23 argA, argB, argC, argD, argE, cyclodeaminase
Planococcus halocryophilus Or1 proB, proA, proC
Pleomorphomonas diazotrophica R5-392 argJ, argB, argC, argD, cyclodeaminase
Polaribacter dokdonensis DSW-5 argA, argB, argC, argD, argE?, OAT, proC
Pontibacillus litoralis JSM 072002 proB, proA, proC
Pontibacter lucknowensis DM9 argA, argB, argC, argD, argE, OAT, proC
Pontibacter ramchanderi LP43 argA, argB, argC, argD, argE, OAT, proC
Pontimonas salivibrio CL-TW6 argJ, argB, argC, argD, OAT, proC
Porphyrobacter dokdonensis DSW-74 proB, proA, proC
Pseudoalteromonas arctica A 37-1-2 proB, proA, proC
Pseudomonas baetica a390 proB, proA, proC
Pseudomonas litoralis 2SM5 proB, proA, proC
Pseudomonas taeanensis MS-3 proB, proA, proC
Pseudovibrio axinellae Ad2 argA, argB, argC, argD, argE, cyclodeaminase
Psychrobacter arcticus 273-4 proB, proA, proC
Psychrobacter cryohalolentis K5 argA, argB, argC, argD, argE, cyclodeaminase
Psychromonas ingrahamii 37 proB, proA, proC
Psychromonas ossibalaenae JAMM 0738 argA, argB, argC, argD, argE, cyclodeaminase
Rhizobium freirei PRF 81 argA, argB, argC, argD, argE, cyclodeaminase
Rhizobium grahamii CCGE 502 argJ, argB, argC, argD, OAT, proC
Rhizobium subbaraonis JC85 argJ, argB, argC, argD, OAT, proC
Rhodanobacter denitrificans 2APBS1 argA, argB, argC, argD, argE, OAT, proC
Rhodobacter johrii JA192 proB, proA, proC
Rhodobacter maris JA276 proB, proA, proC
Rhodobacter ovatus JA234 proB, proA, proC
Rhodobacter viridis JA737 proB, proA, proC
Rhodococcus qingshengii djl-6-2 proB, proA, proC
Rhodopseudomonas pseudopalustris DSM 123 proB, proA, proC
Roseateles aquatilis CCUG 48205 proB, proA, proC
Roseivirga spongicola UST030701-084 argA, argB, argC, argD, argE, OAT, proC
Rubrivirga marina SAORIC-28 proB, proA, proC
Ruegeria conchae TW15 argA, argB, argC, argD, argE, cyclodeaminase
Saccharomonospora marina XMU15 argJ, argB, argC, argD, OAT, proC
Salinicoccus carnicancri Crm proB, proA, proC
Serinicoccus profundi MCCC 1A05965 proB, proA, proC
Shewanella halifaxensis HAW-EB4 proB, proA, proC
Skermanella stibiiresistens SB22 argA, argB, argC, argD, argE, OAT, proC
Snodgrassella alvi wkB2 proB, proA, proC
Sphaerochaeta globosa Buddy proB, proA, proC
Sphaerochaeta pleomorpha Grapes proB, proA, proC
Sphingobium baderi LL03 proB, proA, proC
Sphingobium czechense LL01 proB, proA, proC
Sphingobium quisquiliarum P25 proB, proA, proC
Sphingomonas histidinilytica UM2 proB, proA, proC
Sphingomonas indica Dd16 argJ, argB, argC, argD, OAT, proC
Sphingomonas laterariae LNB2 proB, proA, proC
Sphingopyxis indica DS15 proB, proA, proC
Sphingopyxis terrae UI2 proB, proA, proC
Sporolactobacillus vineae SL153 proB, proA, proC
Streptacidiphilus oryzae TH49 argJ, argB, argC, argD, OAT, proC
Streptococcus anginosus CCUG 39159 proB, proA, proC
Streptococcus massiliensis 4401825 proB, proA, proC
Streptococcus oralis 7747 proB, proA, proC
Streptococcus oralis AZ_3a proB, proA, proC
Streptomyces kebangsaanensis SUK12 argJ, argB, argC, argD, OAT, proC
Succinatimonas hippei YIT 12066 proB, proA, proC
Sulfurimonas gotlandica GD1 proB, proA, proC
Tatumella morbirosei LMG 23360 proB, proA, proC
Thauera humireducens SgZ-1 argJ, argB, argC, argD, OAT, proC
Thermoactinomyces daqus H-18 argJ, argB, argC, argD, OAT, proC
Thermobifida halotolerans YIM 90462 argJ, argB, argC, argD, OAT, proC
Thermodesulfovibrio aggregans TGE-P1 proB, proA, proC
Thermophagus xiamenensis HS1 proB, proA, proC
Thermovenabulum gondwanense R270 proB, proA, proC
Thioclava dalianensis DLFJ1-1 argA, argB, argC, argD, argE, cyclodeaminase
Thiohalospira halophila HL 3 proB, proA, proC
Tistlia consotensis USBA 355 proB, proA, proC
Vagococcus penaei CD276 proB, proA, proC
Verminephrobacter eiseniae EF01-2 proB, proA, proC
Weissella oryzae SG25 proB, proA, proC
Williamsia sterculiae CPCC 203464 argJ, argB, argC, argD, OAT, proC
Yersinia intermedia Y228 proB, proA, proC

Confidence: high confidence medium confidence low confidence
? – known gap: despite the lack of a good candidate for this step, this organism (or a related organism) performs the pathway

This GapMind analysis is from Jul 26 2024. The underlying query database was built on Jul 25 2024.

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About GapMind

Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.

A candidate for a step is "high confidence" if either:

where "other" refers to the best ublast hit to a sequence that is not annotated as performing this step (and is not "ignored").

Otherwise, a candidate is "medium confidence" if either:

Other blast hits with at least 50% coverage are "low confidence."

Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:

GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).

For more information, see:

If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know

by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory