Family Search for PF03690 (MYG1_exonuc)

PF03690 hits 19 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

MYG1_MOUSE / Q9JK81 MYG1 exonuclease; Protein Gamm1; EC 3.1.-.- from Mus musculus (Mouse) (see 3 papers)
Aligns to 45:365 / 380 (84.5%), covers 99.7% of PF03690, 462.4 bits

• function: 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed:31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (PubMed:31081026).
  disruption phenotype: Mutants are vital, fertile and display no gross abnormalities. They show an inconsistent pattern of altered anxiety- like behavior. Mutant males are significantly less anxious than their wild-type littermates, females show increased anxiety in the locomotor activity arena.

MYG1_HUMAN / Q9HB07 MYG1 exonuclease; EC 3.1.-.- from Homo sapiens (Human) (see 4 papers)
Aligns to 46:366 / 376 (85.4%), covers 99.7% of PF03690, 458.7 bits

• function: 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed:31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable).

YEY6_YEAST / P40093 MYG1 protein YER156C from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
Aligns to 16:337 / 338 (95.3%), covers 100.0% of PF03690, 441.5 bits

Or search for genetic data about PF03690 in the Fitness Browser