Family Search for PF04019 (DUF359)

PF04019 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

Q5JIY7 GTP-dependent dephospho-CoA kinase (EC 2.7.1.237) from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (see paper)
DPCKG_THEKO / Q5JIY7 GTP-dependent dephospho-CoA kinase; Dephospho-coenzyme A kinase; DPCK; EC 2.7.1.237 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see 2 papers)
Q5JIY7 dephospho-CoA kinase (EC 2.7.1.24) from Thermococcus kodakarensis (see paper)
Aligns to 50:171 / 177 (68.9%), covers 100.0% of PF04019, 134.9 bits

• function: Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA) (PubMed:31337720, PubMed:38235908). Can also use UTP, with lower efficiency and has weak activity with ATP, but shows a strong preference for GTP as the phosphate donor (PubMed:31337720).
  catalytic activity: 3'-dephospho-CoA + GTP = GDP + CoA + H(+) (RHEA:61156)
  subunit: Monomer in solution.
  disruption phenotype: Disruption of the gene results in CoA auxotrophy.

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