Family Search for PF04074 (DUF386)

PF04074 hits 29 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

YjgK / b4252 DUF386 domain-containing toxin-antitoxin biofilm protein TabA from Escherichia coli K-12 substr. MG1655 (see 3 papers)
TABA_ECOLI / P0AF96 Toxin-antitoxin biofilm protein TabA from Escherichia coli (strain K12) (see paper)
Aligns to 1:148 / 150 (98.7%), covers 99.3% of PF04074, 149.2 bits

• function: Influences biofilm formation. Represses fimbria genes in 8 hours biofilms. May act in response to the combined activity of several toxin-antitoxin (TA) systems.
  disruption phenotype: Deletion increases biofilm formation after 8 hours and decreases biofilm formation after 24 hours.

NANQ_HAEIN / P44583 N-acetylneuraminate anomerase; N-acetylneuraminate openase from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 2 papers)
Aligns to 1:151 / 155 (97.4%), covers 99.3% of PF04074, 144.8 bits

• function: Opens both the alpha- and beta-forms of N-acetylneuraminate (sialic acid; Neu5Ac) to provide aceneuramate, the preferred substrate for NanA (Probable). Has preferential activity on the beta-anomer rather than the alpha-anomer. Accelerates a reaction that is spontaneous at slightly alkaline pH, facilitates the reaction at acidic pH (By similarity).
  catalytic activity: N-acetyl-alpha-neuraminate = aceneuramate (RHEA:67736)
  catalytic activity: N-acetyl-beta-neuraminate = aceneuramate (RHEA:67740)
  cofactor: Zn(2+) (Has been crystallized with Cu(2+) but reconstitutes with Zn(2+).)

YiaL / b3576 DUF386 domain-containing protein YiaL from Escherichia coli K-12 substr. MG1655 (see 2 papers)
Aligns to 1:150 / 155 (96.8%), covers 100.0% of PF04074, 142.7 bits

YhcH / b3221 DUF386 domain-containing protein YhcH from Escherichia coli K-12 substr. MG1655 (see 5 papers)
nanQ / P45424 N-acetylneuraminate anomerase from Escherichia coli (strain K12) (see 3 papers)
NANQ_ECOLI / P45424 N-acetylneuraminate anomerase NanQ; N-acetylneuraminate openase from Escherichia coli (strain K12) (see 2 papers)
Aligns to 1:149 / 154 (96.8%), covers 100.0% of PF04074, 137.6 bits

• function: Opens both the alpha- and beta-forms of N-acetylneuraminate (sialic acid; Neu5Ac) to provide aceneuramate, the preferred substrate for NanA. Has preferential activity on the beta-anomer rather than the alpha-anomer. Accelerates a reaction that is spontaneous at slightly alkaline pH, facilitates the reaction at acidic pH.
  catalytic activity: N-acetyl-alpha-neuraminate = aceneuramate (RHEA:67736)
  catalytic activity: N-acetyl-beta-neuraminate = aceneuramate (RHEA:67740)
  cofactor: Zn(2+) (The Zn(2+) ion may play a catalytic role.)
  disruption phenotype: No visible effect on growth on Neu5Ac at pH 7.0 and 37 degrees Celsius. Shows slight systematic growth delay at pH 6.0 and 20 degrees Celsius. No visible phenotype on glucose.

EbgC / b3077 DUF386 domain-containing evolved β-D-galactosidase subunit β from Escherichia coli K-12 substr. MG1655 (see paper)
EBGC_ECOLI / P0AC73 Evolved beta-galactosidase subunit beta from Escherichia coli (strain K12) (see paper)
Aligns to 1:140 / 149 (94.0%), covers 99.3% of PF04074, 88.0 bits

• function: Required for full activity of the EbgA enzyme. Exact function not known
  subunit: Heterooctamer of 4 alpha and 4 beta subunits.

Or search for genetic data about PF04074 in the Fitness Browser