Family Search for PF05254 (UPF0203)

PF05254 hits 10 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

MDM35_YEAST / O60200 Mitochondrial distribution and morphology protein 35 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 10 papers)
Aligns to 7:75 / 86 (80.2%), covers 100.0% of PF05254, 101.6 bits

• function: Involved in mitochondrial distribution and morphology. Mediates the import of UPS1, UPS2 and UPS3, 3 atypical mitochondrial intermembrane space (IMS) proteins lacking the two major IMS-targeting signals, into the intermembrane space. The UPS1:MDM35 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space (PubMed:26071601, PubMed:26071602, PubMed:26235513). Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane (PubMed:26071602).
  subunit: Interacts with UPS1, UPS2 and UPS3.

TRIA1_HUMAN / O43715 TP53-regulated inhibitor of apoptosis 1; Protein 15E1.1; WF-1; p53-inducible cell-survival factor; p53CSV from Homo sapiens (Human) (see 3 papers)
Aligns to 2:67 / 76 (86.8%), covers 82.6% of PF05254, 93.3 bits

• function: Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003).
  catalytic activity: a 1,2-diacyl-sn-glycero-3-phosphate(in) = a 1,2-diacyl-sn- glycero-3-phosphate(out) (RHEA:36435)
  subunit: Monomer (PubMed:26071602). Interacts with APAF1 and HSP70 (PubMed:15735003). Forms a complex with PRELID1 in the mitochondrion intermembrane space (PubMed:23931759). Interacts with PRELID3A (PubMed:26071602).

TRIA1_XENTR / A9ULB4 TP53-regulated inhibitor of apoptosis 1; p53-inducible cell-survival factor; p53csv from Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) (see paper)
Aligns to 2:67 / 78 (84.6%), covers 82.6% of PF05254, 90.2 bits

• function: Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. The triap1:prelid1 complex probably functions as a phosphatidic acid (PA) transporter across the mitochondrion intermembrane space to provide PA for cardiolipin CL synthesis in the inner membrane. Likewise, the triap1:prelid3a complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (By similarity). Required for pronephros development; probably involved at an early stage in the formation of pronephric components derived from the somatic layer (PubMed:18472403).
  catalytic activity: a 1,2-diacyl-sn-glycero-3-phosphate(in) = a 1,2-diacyl-sn- glycero-3-phosphate(out) (RHEA:36435)
  subunit: Monomer. Forms a complex with prelid1 in the mitochondrion intermembrane space. Interacts with prelid3a.

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