Family Search for PF05346 (DUF747)

PF05346 hits 12 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

TAPT1_SCHPO / O60067 Endoplasmic reticulum membrane protein 65 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
Aligns to 218:585 / 649 (56.7%), covers 99.0% of PF05346, 386.2 bits

• function: May be involved in membrane protein folding.
  subunit: Interacts with slp1.

TAPT1_MOUSE / Q4VBD2 Transmembrane anterior posterior transformation protein 1 from Mus musculus (Mouse) (see paper)
Aligns to 152:456 / 564 (54.1%), covers 99.4% of PF05346, 385.0 bits

• function: Plays a role in primary cilia formation (By similarity). May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity).
  disruption phenotype: Mice die during perinatal development and are the cause of the L5Jcs1 phenotype. They exhibit posterior-to-anterior transformations of the vertebral column midsection, similar to mice deficient for Hoxc8 and Hoxc9.

TAPT1_HUMAN / Q6NXT6 Transmembrane anterior posterior transformation protein 1 homolog; Cytomegalovirus partial fusion receptor from Homo sapiens (Human) (see 2 papers)
Aligns to 155:459 / 567 (53.8%), covers 99.4% of PF05346, 384.8 bits

• function: Plays a role in primary cilia formation (PubMed:26365339). May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity).
  function: (Microbial infection) In case of infection, may act as a fusion receptor for cytomegalovirus (HCMV) strain AD169.

TAPT1_DANRE / A2BIE7 Transmembrane anterior posterior transformation protein 1 homolog from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
Aligns to 152:456 / 567 (53.8%), covers 99.4% of PF05346, 378.6 bits

• function: Plays a role in primary cilia formation (PubMed:26365339). Involved in cartilage and bone development (PubMed:26365339). May play a role in the differentiation of cranial neural crest cells (PubMed:26365339). May act as a downstream effector of hoxc8 during development (By similarity).

TAPT1_YEAST / P40085 Endoplasmic reticulum membrane protein 65; 65 kDa endoplasmic reticulum membrane protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
Aligns to 143:457 / 556 (56.7%), covers 99.0% of PF05346, 334.0 bits

• function: May be involved in membrane protein folding.
  subunit: Interacts with SLP1.

POD1_ARATH / F4HVJ3 Protein POLLEN DEFECTIVE IN GUIDANCE 1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 303:611 / 624 (49.5%), covers 99.0% of PF05346, 322.9 bits

• function: Probable component of the calreticulin 3 (CRT3) complex, acting probably as a co-chaperone involved in protein retention in the endoplasmic reticulum lumen. Required for micropylar pollen tube guidance. Plays an essential role in cell plate orientation or positioning in early embryo patterning.
  subunit: Interacts with CRT3, but not with CRT1 or CNX.
  disruption phenotype: Defective in micropylar pollen tube guidance leading to zygotic lethality.

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