Family Search for PF06688 (DUF1187)

PF06688 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

YdaC / b1347 Rac prophage; double-strand break reduction protein from Escherichia coli K-12 substr. MG1655 (see 4 papers)
RCBA_ECOLI / P33230 Double-strand break reduction protein from Escherichia coli (strain K12) (see 2 papers)
Aligns to 2:62 / 69 (88.4%), covers 100.0% of PF06688, 131.7 bits

• function: Helps to maintain the integrity of the chromosome by lowering the steady-state level of double strand breaks (PubMed:22343303). This region of DNA acts as an antitoxin to toxin RalR, a DNase, but it seems to be sRNA RalA that has the antitoxin activity and not this putative protein. Therefore the identity of this as a protein-coding gene has been cast into doubt (PubMed:24748661).
  disruption phenotype: Mutants show increased numbers of double-strand breaks (PubMed:22343303). The single ralR and double ralR-ralA mutant have increased sensitivity to the antibiotic fosfomycin.

Or search for genetic data about PF06688 in the Fitness Browser