Family Search for PF06749 (DUF1218)

PF06749 hits 15 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

DEAL2_ARATH / O81898 Protein DESIGUAL 2 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 58:146 / 168 (53.0%), covers 98.9% of PF06749, 78.8 bits

• function: Involved, partially redundantly with VCC/DEAL1 and DEAL3, to ensure bilateral symmetry development and early leaf margin patterning, probably via the regulation of auxin and CUC2 distribution.
  disruption phenotype: Developmental defects of pistils, some being bent or coiled or twisted, and some showing unfused carpels with exposed ovules (PubMed:29139551). The vcc-3 deal2-1 double mutant shows leaf asymmetry (PubMed:29139551). The vcc-3 deal2-1 deal3-1 triple mutant shows a strong leaf asymmetry (PubMed:29139551).

DEAL1_ARATH / Q9ZV57 Protein VASCULATURE COMPLEXITY AND CONNECTIVITY; Protein DESIGUAL 1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Aligns to 58:146 / 163 (54.6%), covers 100.0% of PF06749, 76.4 bits

• function: Required, together with OPS, for embryo provasculature development and cotyledon vascular complexity and connectivity (PubMed:25149602). Necessary, partially redundantly with DEAL2 and DEAL3, to ensure bilateral symmetry development and early leaf margin patterning, probably via the regulation of auxin and CUC2 distribution (PubMed:29139551). Regulates cell proliferation but not cell expansion (PubMed:29139551).
  subunit: Interacts with OPS.
  disruption phenotype: Defects in vein connectivity early in mutant embryo development leading to reduced complexity of cotyledon vein networks and disconnected veins, including in embryos provasculatures (PubMed:25149602). The mutant deal1-1 exhibits a bilateral symmetry breaking but no obvious defects in dorsoventrality; early leaf primordia fail to acquire bilateral symmetry and instead form ectopic lobes and sinuses (PubMed:29139551). Developmental defects of pistils, some being bent or coiled or twisted, and some showing unfused carpels with exposed ovules (PubMed:29139551). In leaves, marginal cells expressing properly polarized PIN1 are badly recruited, thus leading to misplaced auxin maxima, as well as defects in cell proliferation but not in cell expansion (PubMed:29139551). Altered spatial pattern of CUC2 (PubMed:29139551). The double mutant vcc ops exhibits a complete loss of high-complexity vascular networks (PubMed:25149602). The vcc-3 deal2-1 and vcc-3 deal3-1 double mutants show leaf asymmetry (PubMed:29139551). The vcc-3 deal2-1 deal3-1 triple mutant shows a strong leaf asymmetry (PubMed:29139551).

MWL1_ARATH / A2RVU1 Protein MODIFYING WALL LIGNIN-1; MWL-1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 58:148 / 175 (52.0%), covers 98.9% of PF06749, 74.5 bits

• function: Together with MWL2, contributes to secondary cell wall biology, specifically lignin biosynthesis.
  subunit: Interacts with CRK19.
  disruption phenotype: No visible phenotype. Double mutants lacking both MWL1 and MWL2 exhibit smaller rosettes with a decrease in rosette fresh weight and stem height associated with a reduction in total lignin content and an increase in syringyl/guaiacyl (S/G) monomer ratio.

DEAL3_ARATH / A2RVQ4 Protein DESIGUAL 3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 65:153 / 184 (48.4%), covers 98.9% of PF06749, 68.8 bits

• function: Involved, partially redundantly with VCC/DEAL1 and DEAL2, to ensure bilateral symmetry development and early leaf margin patterning, probably via the regulation of auxin and CUC2 distribution.
  disruption phenotype: No visible phenotype (PubMed:29139551). The vcc-3 deal3-1 double mutant shows leaf asymmetry (PubMed:29139551). The vcc-3 deal2-1 deal3-1 triple mutant shows a strong leaf asymmetry (PubMed:29139551).

MWL2_ARATH / O65708 Protein MODIFYING WALL LIGNIN-2; MWL-2 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 55:151 / 217 (44.7%), covers 96.8% of PF06749, 66.7 bits

• function: Together with MWL1, contributes to secondary cell wall biology, specifically lignin biosynthesis.
  disruption phenotype: No visible phenotype. Double mutants lacking both MWL1 and MWL2 exhibit smaller rosettes with a decrease in rosette fresh weight and stem height associated with a reduction in total lignin content and an increase in syringyl/guaiacyl (S/G) monomer ratio.

DEAL4_ARATH / O23040 Protein DESIGUAL 4 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 66:156 / 204 (44.6%), covers 100.0% of PF06749, 43.4 bits

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