Family Search for PF07853 (DUF1648)

PF07853 hits 12 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

YBGB_BACSU / O31460 Uncharacterized membrane protein YbgB from Bacillus subtilis (strain 168) (see paper)
Aligns to 12:60 / 91 (53.8%), covers 95.9% of PF07853, 49.6 bits

SDPI_BACSU / O32241 Immunity protein SdpI from Bacillus subtilis (strain 168) (see 4 papers)
Aligns to 9:56 / 207 (23.2%), covers 100.0% of PF07853, 40.9 bits

• function: Immunity protein that provides protection for the cell against the toxic effects of SDP, its own SdpC-derived killing factor, and that functions as a receptor/signal transduction protein as well. Once SDP accumulates in the extracellular milieu, SdpI binds to SDP, causing sequestration of SdpR at the bacterial membrane.
  disruption phenotype: Results in increased SigW expression which is dependent on SdpC. Results in weaker growth (70% of wild-type cell density) on LB medium, with more pronounced effects on sporulation medium (15% of wild-type). Concomitant deletion of SigW results in greatly diminished growth (5% of wild-type on LB and 3% on sporulation medium). Over time, single SdpI mutant stops growing on sporulation medium, while the SdpI SigW double mutant eventually lyses. Deletion of RsiW restores growth of the SdpI single mutant to near wild-type levels.

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