Family Search for PF07896 (DUF1674)

PF07896 hits 10 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

SDHF4_HUMAN / Q5VUM1 Succinate dehydrogenase assembly factor 4, mitochondrial; SDH assembly factor 4; SDHAF4 from Homo sapiens (Human) (see paper)
Aligns to 59:108 / 108 (46.3%), covers 96.0% of PF07896, 78.7 bits

• function: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit SDHA in its FAD-bound form, blocking the generation of excess reactive oxygen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDHB into the SDH catalytic dimer (By similarity).
  subunit: Interacts with SDHA in its FAD-bound form.

SDHF4_MOUSE / Q8BTE0 Succinate dehydrogenase assembly factor 4, mitochondrial; SDH assembly factor 4; SDHAF4 from Mus musculus (Mouse) (see paper)
Aligns to 55:104 / 104 (48.1%), covers 94.0% of PF07896, 78.7 bits

• function: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit Sdha in its FAD-bound form, blocking the generation of excess reactive oxygen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit Sdhb into the SDH catalytic dimer (By similarity).
  subunit: Interacts with Sdha in its FAD-bound form.

SDHF4_DROME / Q9VLU6 Succinate dehydrogenase assembly factor 4, mitochondrial; SDH assembly factor 4; SDHAF4; Starvation-upregulated protein from Drosophila melanogaster (Fruit fly) (see paper)
Aligns to 69:118 / 118 (42.4%), covers 92.0% of PF07896, 75.5 bits

• function: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit SdhA in its FAD-bound form, blocking the generation of excess reactive oxygen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SdhB into the SDH catalytic dimer (By similarity).
  subunit: Interacts with SdhA in its FAD-bound form.

SDHF4_YEAST / P38345 Succinate dehydrogenase assembly factor 4, mitochondrial; SDH assembly factor 4; SDHAF4; Found in mitochondrial proteome protein 21 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
Aligns to 94:138 / 138 (32.6%), covers 74.0% of PF07896, 62.5 bits

• function: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Binds to the flavoprotein subunit SDH1 in its FAD-bound form, blocking the generation of excess reactive oxygen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDH2 into the SDH catalytic dimer.
  subunit: Interacts with SDH1 in its FAD-bound form.

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