Family Search for PF08508 (DUF1746)

Running HMMer for PF08508

PF08508 hits 6 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

DSCD_ASPFU / Q4WX61 DSC E3 ubiquitin ligase complex subunit D; Defective for SREBP cleavage protein D from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see paper)
Aligns to 60:173 / 331 (34.4%), covers 100.0% of PF08508, 150.1 bits

• function: Component of the DSC E3 ubiquitin ligase complex which is required for the srbA transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions (PubMed:23104569). Required for growth during hypoxia and triazole drug susceptibility, as well as for virulence in a murine model of invasive pulmonary aspergillosis (IPA) (PubMed:23104569).
  subunit: Component of the DSC E3 ubiquitin ligase complex composed of dscA, dscB, dscC and dscD.
  disruption phenotype: Impairs growth on solid media under hypoxia and leads to triazole susceptibility (PubMed:23104569). Impairs virulence in a murine model of invasive pulmonary aspergillosis (IPA) (PubMed:23104569).

DSCD_ASPFC / B0XYF7 DSC E3 ubiquitin ligase complex subunit D; Defective for SREBP cleavage protein D from Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10) (Neosartorya fumigata) (see paper)
Aligns to 60:173 / 331 (34.4%), covers 100.0% of PF08508, 148.1 bits

• function: Component of the DSC E3 ubiquitin ligase complex which is required for the srbA transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions (PubMed:23104569). Required for growth during hypoxia and triazole drug susceptibility, as well as for virulence in a murine model of invasive pulmonary aspergillosis (IPA) (PubMed:23104569).
  subunit: Component of the DSC E3 ubiquitin ligase complex composed of dscA, dscB, dscC and dscD.
  disruption phenotype: Impairs growth on solid media under hypoxia and leads to triazole susceptibility (PubMed:23104569). Impairs virulence in a murine model of invasive pulmonary aspergillosis (IPA) (PubMed:23104569).

DSC4_SCHPO / O14175 DSC E3 ubiquitin ligase complex subunit 4; Defective for SREBP cleavage protein 4 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
Aligns to 18:129 / 281 (39.9%), covers 100.0% of PF08508, 111.1 bits

• function: Component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex also plays an important role in the multivesicular body (MVB) pathway and functions in a post- endoplasmic reticulum pathway for protein degradation.
  subunit: Component of the DSC E3 ubiquitin ligase complex composed of dsc1, dsc2, dsc3 and dsc4.

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