Family Search for PF08538 (DUF1749)

PF08538 hits 9 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

YKM6_SCHPO / Q9C0Y8 UPF0613 protein PB24D3.06c from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
Aligns to 1:311 / 316 (98.4%), covers 100.0% of PF08538, 403.8 bits

SIDJ_ASPFU / Q4WF56 Fusarinine C esterase sidJ; EC 3.1.-.- from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see paper)
Aligns to 4:349 / 354 (97.7%), covers 97.7% of PF08538, 331.2 bits

• function: Displays specific fusarinine C (FsC) esterase activity but does not hydrolyze triacetylfusarinine C (TAFC), which has the same core structure as fusarinine C (PubMed:24038704). Both extra- and intracellular siderophores have been shown to be crucial for the virulence (PubMed:24038704). Subsequent to chelation of iron and uptake, FsC and TAFC are hydrolyzed and the iron is transferred to the metabolism or to the intracellular siderophore ferricrocin (FC) for transport and storage of iron (PubMed:24038704).
  disruption phenotype: Leads to decreased growth and increased intracellular accumulation of hydrolysis products of the siderophore fusarinine C (PubMed:24038704).

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