Family Search for PF08818 (DUF1801)

PF08818 hits 14 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

FRA_BACSU / Q797E6 Intracellular iron chaperone frataxin; Fra; Iron channeling protein frataxin from Bacillus subtilis (strain 168) (see 4 papers)
Aligns to 16:111 / 123 (78.0%), covers 100.0% of PF08818, 57.0 bits

• function: Plays an essential role in iron intracellular trafficking to iron cofactor biogenesis systems including iron-sulfur cluster (Fe-S) or heme assembly (PubMed:21744456, PubMed:25826316). Promotes the biosynthesis of iron-sulfur clusters by delivering Fe to the complex composed of the cysteine desulfurase SufS and the zinc-dependent sulfurtransferase SufU (PubMed:27382962). Also plays a critical role in coproporphyrin-dependent heme b biogenesis and thus provides an essential function for the bacterial global metabolism.
  cofactor: Fe(2+) (Binds 1.0 Fe(2+) (PubMed:20087498) to 1.5 to 3.2 Fe(2+) per monomer (PubMed:21744456).)
  subunit: Homodimer, upon Fe(2+) binding (PubMed:20087498). Interacts with the SufS/SufU complex (PubMed:27382962). Interacts with CpfC (PubMed:25826316).
  disruption phenotype: Reduced growth in rich medium, unable to grow in minimal medium. Reduced activity of Fe-S-dependent aconitase (citB). Reactive oxygen species are drastically reduced. No bacillibactin (BB), an endogenous siderophore, produced. 20% higher intracellular iron concentrations.

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